LOCUS       HUMSF2P33               1428 bp    mRNA    linear   HUM 24-NOV-1993
DEFINITION  Human SF2p33 mRNA, complete cds.
ACCESSION   M69040
VERSION     M69040.1
KEYWORDS    SF2p33.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1428)
  AUTHORS   Krainer,A.R., Mayeda,A., Kozak,D. and Binns,G.
  TITLE     Functional expression of cloned human splicing factor SF2: homology
            to RNA-binding proteins, U1 70K, and Drosophila splicing regulators
  JOURNAL   Cell 66 (2), 383-394 (1991)
   PUBMED   1830244
COMMENT     Original source text: Homo sapiens cDNA to mRNA.
            Comments: SF2p33 is an essential pre-mRNA splicing factor, which
            can also affect alternative 5' splice site selection in vitro by
            stimulating the use of proximal 5' splice sites.
            (Krainer, A.R., Conway, G.C., and Kozak, D. (1990) Purification and
            Characterization of SF2, a Human Pre-mRNA Splicing Factor. Genes
            Dev. 4, 1158-1171; Krainer, A.R., Conway, G.C., and Kozak, D.
            (1990) The Essential Pre-mRNA Splicing Factor SF2 Influences 5'
            Splice Site Selection by Activating Proximal Sites. Cell 62,
            35-42). This factor is also known as ASF (Ge, H., and
            Manley, J.L. (1990) A protein Factor, ASF, Controls Alternative
            Splicing of SV40 Early Pre-mRNA In Vitro. Cell 62, 25-34). SF2 p33
            consists of two polypeptides of apparent molecular weight 33 kd,
            approximately, although their predicted molecular weight is 27,744
            daltons. The two forms appear to differ by the extent of
            post-translational modification, which includes phosphorylation.
            SF2p33 binds RNA and promotes the annealing of complementary RNAs.
            It is required for assembly of pre-spliceosome complexes. The
            N-termini of the HeLa polypeptides are blocked.
FEATURES             Location/Qualifiers
     source          1..1428
                     /db_xref="H-InvDB:HIT000196208"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /sex="female"
     5'UTR           <1..124
     CDS             125..871
                     /function="pre-mRNA splicing factor"
                     /codon_start=1
                     /product="SF2p33"
                     /protein_id="AAA03476.1"
                     /translation="MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRD
                     IDLKNRRGGPPFAFVEFEDPRDAEDAVYGRDGYDYDGYRLRVEFPRSGRGTGRGGGGG
                     GGGGAPRGRYGPPSRRSENRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRDGTGVV
                     EFVRKEDMTYAVRKLDNTKFRSHEGETAYIRVKVDGPRSPSYGRSRSRSRSRSRSRSR
                     SNSRSRSYSPRRSRGSPRYSPRHSRSRSRT"
     3'UTR           872..1428
BASE COUNT          341 a          296 c          400 g          391 t
ORIGIN      
        1 cgagctgata aaggcgccat tttggagggg ccgcgggaga cgtggtgccg ctgcgggctc
       61 gctctgccgt gcgctaggct tggtgggaag gcctgttctc gagtccgcgc ttttcgtcac
      121 cgccatgtcg ggaggtggtg tgattcgtgg ccccgcaggg aacaacgatt gccgcatcta
      181 cgtgggtaac ttacctccag acatccgaac caaggacatt gaggacgtgt tctacaaata
      241 cggcgctatc cgcgacatcg acctcaagaa tcgccgcggg ggaccgccct tcgccttcgt
      301 tgagttcgag gacccgcgag acgcggaaga cgcggtgtat ggtcgcgacg gctatgatta
      361 cgatgggtac cgtctgcggg tggagtttcc tcgaagcggc cgtggaacag gccgaggcgg
      421 cggcgggggt ggaggtggcg gagctccccg aggtcgctat ggccccccat ccaggcggtc
      481 tgaaaacaga gtggttgtct ctggactgcc tccaagtgga agttggcagg atttaaagga
      541 tcacatgcgt gaagcaggtg atgtatgtta tgctgatgtt taccgagatg gcactggtgt
      601 cgtggagttt gtacggaaag aagatatgac ctatgcagtt cgaaaactgg ataacactaa
      661 gtttagatct catgagggag aaactgccta catccgggtt aaagttgatg ggcccagaag
      721 tccaagttat ggaagatctc gatctcgaag ccgtagtcgt agcagaagcc gtagcagaag
      781 caacagcagg agtcgcagtt actccccaag gagaagcaga ggatcaccac gctattctcc
      841 ccgtcatagc agatctcgct ctcgtacata agatgattgg tgacactttt tgtagaaccc
      901 atgttgtata cagttttcct ttattcagta caatcttttc attttttaat tcaaactgtt
      961 ttgttcagaa tgggctaaag tgttgaattg cattcttgta atatcccctt gctcctaaca
     1021 tctacattcc cttcgtgtct ttgataaatt gtattttaag tgatgtcata gacaggattg
     1081 tttaaattta gttaactcca tactcttcag actgtgatat tgtgtaaatg tctatctgcc
     1141 ctggtttgtg tgaactggga tgttgggggt gtttgtggtt atcttacctg gggaagttct
     1201 tatgtttatc ttgcttttca tgtgtctttc tgtagacata tctgaagaga tggattaaga
     1261 atgctttgga ttaaggattg tggagcacat ttcaatcatt ttaggattgt caaaaggagg
     1321 attgaggagg atcagatcaa taatggaggc aatggtatga ctccaagtgc tattgtcaca
     1381 gatgaaattg gcagtattga ccttatacta aaaggcaggg gctaaaaa
//