LOCUS HUMFASANT 2534 bp mRNA linear HUM 06-MAR-1995
DEFINITION Human Fas antigen (fas) mRNA, complete cds.
ACCESSION M67454
VERSION M67454.1
KEYWORDS Fas antigen; cell surface antigen; transmembrane protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2534)
AUTHORS Itoh,N., Yonehara,S., Ishii,A., Yonehara,M., Mizushima,S.,
Sameshima,M., Hase,A., Seto,Y. and Nagata,S.
TITLE The polypeptide encoded by the cDNA for human cell surface antigen
Fas can mediate apoptosis
JOURNAL Cell 66 (2), 233-243 (1991)
PUBMED 1713127
COMMENT Original source text: Homo sapiens (clone pF58) (tissue library:
pCEV4) cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..2534
/db_xref="H-InvDB:HIT000196183"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="pF58"
/cell_line="KT3"
/tissue_lib="pCEV4"
gene 1..2534
/gene="fas"
CDS 195..1202
/gene="fas"
/codon_start=1
/product="Fas antigen"
/protein_id="AAA63174.1"
/translation="MLGIWTLLPLVLTSVARLSSKSVNAQVTDINSKGLELRKTVTTV
ETQNLEGLHHDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCR
RCRLCDEGHGLEVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLT
SNTKCKEEGSRSNLGWLCLLLLPIPLIVWVKRKEVQKTCRKHRKENQGSHESPTLNPE
TVAINLSDVDLSKYITTIAGVMTLSQVKGFVRKNGVNEAKIDEIKNDNVQDTAEQKVQ
LLRNWHQLHGKKEAYDTLIKDLKKANLCTLAEKIQTIILKDITSDSENSNFRNEIQSL
V"
sig_peptide 195..242
/gene="fas"
mat_peptide 243..1199
/gene="fas"
/product="Fas antigen"
regulatory 1831..1836
/regulatory_class="polyA_signal_sequence"
/gene="fas"
regulatory 2352..2357
/regulatory_class="polyA_signal_sequence"
/gene="fas"
regulatory 2518..2523
/regulatory_class="polyA_signal_sequence"
/gene="fas"
BASE COUNT 817 a 487 c 503 g 727 t
ORIGIN
1 gacgcttctg gggagtgagg gaagcggttt acgagtgact tggctggagc ctcaggggcg
61 ggcactggca cggaacacac cctgaggcca gccctggctg cccaggcgga gctgcctctt
121 ctcccgcggg ttggtggacc cgctcagtac ggagttgggg aagctctttc acttcggagg
181 attgctcaac aaccatgctg ggcatctgga ccctcctacc tctggttctt acgtctgttg
241 ctagattatc gtccaaaagt gttaatgccc aagtgactga catcaactcc aagggattgg
301 aattgaggaa gactgttact acagttgaga ctcagaactt ggaaggcctg catcatgatg
361 gccaattctg ccataagccc tgtcctccag gtgaaaggaa agctagggac tgcacagtca
421 atggggatga accagactgc gtgccctgcc aagaagggaa ggagtacaca gacaaagccc
481 atttttcttc caaatgcaga agatgtagat tgtgtgatga aggacatggc ttagaagtgg
541 aaataaactg cacccggacc cagaatacca agtgcagatg taaaccaaac tttttttgta
601 actctactgt atgtgaacac tgtgaccctt gcaccaaatg tgaacatgga atcatcaagg
661 aatgcacact caccagcaac accaagtgca aagaggaagg atccagatct aacttggggt
721 ggctttgtct tcttcttttg ccaattccac taattgtttg ggtgaagaga aaggaagtac
781 agaaaacatg cagaaagcac agaaaggaaa accaaggttc tcatgaatct ccaaccttaa
841 atcctgaaac agtggcaata aatttatctg atgttgactt gagtaaatat atcaccacta
901 ttgctggagt catgacacta agtcaagtta aaggctttgt tcgaaagaat ggtgtcaatg
961 aagccaaaat agatgagatc aagaatgaca atgtccaaga cacagcagaa cagaaagttc
1021 aactgcttcg taattggcat caacttcatg gaaagaaaga agcgtatgac acattgatta
1081 aagatctcaa aaaagccaat ctttgtactc ttgcagagaa aattcagact atcatcctca
1141 aggacattac tagtgactca gaaaattcaa acttcagaaa tgaaatccaa agcttggtct
1201 agagtgaaaa acaacaaatt cagttctgag tatatgcaat tagtgtttga aaagattctt
1261 aatagctggc tgtaaatact gcttggtttt ttactgggta cattttatca tttattagcg
1321 ctgaagagcc aacatatttg tagattttta atatctcatg attctgcctc caaggatgtt
1381 taaaatctag ttgggaaaac aaacttcatc aagagtaaat gcagtggcat gctaagtacc
1441 caaataggag tgtatgcaga ggatgaaaga ttaagattat gctctggcat ctaacatatg
1501 attctgtagt atgaatgtaa tcagtgtatg ttagtacaaa tgtctatcca caggctaacc
1561 ccactctatg aatcaataga agaagctatg accttttgct gaaatatcag ttactgaaca
1621 ggcaggccac tttgcctcta aattacctct gataattcta gagattttac catatttcta
1681 aactttgttt ataactctga gaagatcata tttatgtaaa gtatatgtat ttgagtgcag
1741 aatttaaata aggctctacc tcaaagacct ttgcacagtt tattggtgtc atattataca
1801 atatttcaat tgtgaattca catagaaaac attaaattat aatgtttgac tattatatat
1861 gtgtatgcat tttactggct caaaactacc tacttctttc tcaggcatca aaagcatttt
1921 gagcaggaga gtattactag agctttgcca cctctccatt tttgccttgg tgctcatctt
1981 aatggcctaa tgcaccccca aacatggaaa tatcaccaaa aaatacttaa tagtccacca
2041 aaaggcaaga ctgcccttag aaattctagc ctggtttgga gatactaact gctctcagag
2101 aaagtagctt tgtgacatgt catgaaccca tgtttgcaat caaagatgat aaaatagatt
2161 cttatttttc ccccaccccc gaaaatgttc aataatgtcc catgtaaaac ctgctacaaa
2221 tggcagctta tacatagcaa tggtaaaatc atcatctgga tttaggaatt gctcttgtca
2281 taccctcaag tttctaagat ttaagattct ccttactact atcctacgtt taaatatctt
2341 tgaaagtttg tattaaatgt gaattttaag aaataatatt tatatttctg taaatgtaaa
2401 ctgtgaagat agttataaac tgaagcagat acctggaacc acctaaagaa cttccattta
2461 tggaggattt ttttgcccct tgtgtttgga attataaaat ataggtaaaa gtacgtaatt
2521 aaataatgtt tttg
//