LOCUS HUMPTKJAK1 3541 bp mRNA linear HUM 27-APR-1993
DEFINITION Human protein-tyrosine kinase (JAK1) mRNA, complete cds.
ACCESSION M64174 M35203
VERSION M64174.1
KEYWORDS protein-tyrosine kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3541)
AUTHORS Wilks,A.F., Harpur,A.G., Kurban,R.R., Ralph,S.J., Zurcher,G. and
Ziemiecki,A.
TITLE Two novel protein-tyrosine kinases, each with a second
phosphotransferase-related catalytic domain, define a new class of
protein kinase
JOURNAL Mol. Cell. Biol. 11 (4), 2057-2065 (1991)
PUBMED 1848670
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..3541
/db_xref="H-InvDB:HIT000196101"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..3541
/gene="JAK1"
CDS 76..3504
/gene="JAK1"
/codon_start=1
/product="protein-tyrosine kinase"
/protein_id="AAA36527.1"
/translation="MAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYT
AEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFT
NWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAP
IRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIR
QRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFET
SMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKL
ENKDKKDEEKNKIREEWNNFSFFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALS
FVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGM
YVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLG
DLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRI
LKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFF
EAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKV
AKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQEC
IERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRC
RPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSRKKNQPTEVDP
THFEKRFLKRIRDLGEGHFGKVELCRYDPEDNTGEQVAVKSLKPESGGNHIADLKKEI
EILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYA
VQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRD
SPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMT
VTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK"
BASE COUNT 1054 a 806 c 876 g 805 t
ORIGIN
1 tccagtttgc ttcttggaga acactggaca gctgaataaa tgcagtatct aaatataaaa
61 gaggactgca atgccatggc tttctgtgct aaaatgagga gctccaagaa gactgaggtg
121 aacctggagg cccctgagcc aggggtggaa gtgatcttct atctgtcgga cagggagccc
181 ctccggctgg gcagtggaga gtacacagca gaggaactgt gcatcagggc tgcacaggca
241 tgccgtatct ctcctctttg tcacaacctc tttgccctgt atgacgagaa caccaagctc
301 tggtatgctc caaatcgcac catcaccgtt gatgacaaga tgtccctccg gctccactac
361 cggatgaggt tctatttcac caattggcat ggaaccaacg acaatgagca gtcagtgtgg
421 cgtcattctc caaagaagca gaaaaatggc tacgagaaaa aaaagattcc agatgcaacc
481 cctctccttg atgccagctc actggagtat ctgtttgctc agggacagta tgatttggtg
541 aaatgcctgg ctcctattcg agaccccaag accgagcagg atggacatga tattgagaac
601 gagtgtctag ggatggctgt cctggccatc tcacactatg ccatgatgaa gaagatgcag
661 ttgccagaac tgcccaagga catcagctac aagcgatata ttccagaaac attgaataag
721 tccatcagac agaggaacct tctcaccagg atgcggataa ataatgtttt caaggatttc
781 ctaaaggaat ttaacaacaa gaccatttgt gacagcagcg tgtccacgca tgacctgaag
841 gtgaaatact tggctacctt ggaaactttg acaaaacatt acggtgctga aatatttgag
901 acttccatgt tactgatttc atcagaaaat gagatgaatt ggtttcattc gaatgacggt
961 ggaaacgttc tctactacga agtgatggtg actgggaatc ttggaatcca gtggaggcat
1021 aaaccaaatg ttgtttctgt tgaaaaggaa aaaaataaac tgaagcggaa aaaactggaa
1081 aataaagaca agaaggatga ggagaaaaac aagatccggg aagagtggaa caatttttca
1141 ttcttccctg aaatcactca cattgtaata aaggagtctg tggtcagcat taacaagcag
1201 gacaacaaga aaatggaact gaagctctct tcccacgagg aggccttgtc ctttgtgtcc
1261 ctggtagatg gctacttccg gctcacagca gatgcccatc attacctctg caccgacgtg
1321 gcccccccgt tgatcgtcca caacatacag aatggctgtc atggtccaat ctgtacagaa
1381 tacgccatca ataaattgcg gcaagaagga agcgaggagg ggatgtacgt gctgaggtgg
1441 agctgcaccg actttgacaa catcctcatg accgtcacct gctttgagaa gtctgagcag
1501 gtgcagggtg cccagaagca gttcaagaac tttcagatcg aggtgcagaa gggccgctac
1561 agtctgcacg gttcggaccg cagcttcccc agcttgggag acctcatgag ccacctcaag
1621 aagcagatcc tgcgcacgga taacatcagc ttcatgctaa aacgctgctg ccagcccaag
1681 ccccgagaaa tctccaacct gctggtggct actaagaaag cccaggagtg gcagcccgtc
1741 taccccatga gccagctgag tttcgatcgg atcctcaaga aggatctggt gcagggcgag
1801 caccttggga gaggcacgag aacacacatc tattctggga ccctgatgga ttacaaggat
1861 gacgaaggaa cttctgaaga gaagaagata aaagtgatcc tcaaagtctt agaccccagc
1921 cacagggata tttccctggc cttcttcgag gcagccagca tgatgagaca ggtctcccac
1981 aaacacatcg tgtacctcta tggcgtctgt gtccgcgacg tggagaatat catggtggaa
2041 gagtttgtgg aagggggtcc tctggatctc ttcatgcacc ggaaaagtga tgtccttacc
2101 acaccatgga aattcaaagt tgccaaacag ctggccagtg ccctgagcta cttggaggat
2161 aaagacctgg tccatggaaa tgtgtgtact aaaaacctcc tcctggcccg tgagggaatc
2221 gacagtgagt gtggcccatt catcaagctc agtgaccccg gcatccccat tacggtgctg
2281 tctaggcaag aatgcattga acgaatccca tggattgctc ctgagtgtgt tgaggactcc
2341 aagaacctga gtgtggctgc tgacaagtgg agctttggaa ccacgctctg ggaaatctgc
2401 tacaatggcg agatcccctt gaaagacaag acgctgattg agaaagagag attctatgaa
2461 agccggtgca ggccagtgac accatcatgt aaggagctgg ctgacctcat gacccgctgc
2521 atgaactatg accccaatca gaggcctttc ttccgagcca tcatgagaga cattaataag
2581 cttgaagagc agaatccaga tattgtttcc agaaaaaaaa accagccaac tgaagtggac
2641 cccacacatt ttgagaagcg cttcctaaag aggatccgtg acttgggaga gggccacttt
2701 gggaaggttg agctctgcag gtatgacccc gaagacaata caggggagca ggtggctgtt
2761 aaatctctga agcctgagag tggaggtaac cacatagctg atctgaaaaa ggaaatcgag
2821 atcttaagga acctctatca tgagaacatt gtgaagtaca aaggaatctg cacagaagac
2881 ggaggaaatg gtattaagct catcatggaa tttctgcctt cgggaagcct taaggaatat
2941 cttccaaaga ataagaacaa aataaacctc aaacagcagc taaaatatgc cgttcagatt
3001 tgtaagggga tggactattt gggttctcgg caatacgttc accgggactt ggcagcaaga
3061 aatgtccttg ttgagagtga acaccaagtg aaaattggag acttcggttt aaccaaagca
3121 attgaaaccg ataaggagta ttacaccgtc aaggatgacc gggacagccc tgtgttttgg
3181 tatgctccag aatgtttaat gcaatctaaa ttttatattg cctctgacgt ctggtctttt
3241 ggagtcactc tgcatgagct gctgacttac tgtgattcag attctagtcc catggctttg
3301 ttcctgaaaa tgataggccc aacccatggc cagatgacag tcacaagact tgtgaatacg
3361 ttaaaagaag gaaaacgcct gccgtgccca cctaactgtc cagatgaggt ttatcagctt
3421 atgagaaaat gctgggaatt ccaaccatcc aatcggacaa gctttcagaa ccttattgaa
3481 ggatttgaag cacttttaaa ataagaagca tgaataacat ttaaattcca cagattatca
3541 a
//