LOCUS HUMCYP27 1880 bp mRNA linear HUM 02-NOV-1994
DEFINITION Human sterol 27-hydroxylase (CYP27) mRNA, complete cds.
ACCESSION M62401
VERSION M62401.1
KEYWORDS sterol 27-hydroxylase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1880)
AUTHORS Cali,J.J. and Russell,D.W.
TITLE Characterization of human sterol 27-hydroxylase. A mitochondrial
cytochrome P-450 that catalyzes multiple oxidation reaction in bile
acid biosynthesis
JOURNAL J. Biol. Chem. 266 (12), 7774-7778 (1991)
PUBMED 1708392
COMMENT Original source text: Human, cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1880
/db_xref="H-InvDB:HIT000196016"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="2q33-qter"
gene 1..1880
/gene="CYP27"
CDS 22..1617
/gene="CYP27"
/codon_start=1
/product="sterol 27-hydroxylase"
/protein_id="AAA52142.1"
/db_xref="GDB:G00-128-129"
/translation="MAALGCARLRWALRGAGRGLCPHGARAKAAIPAALPSDKATGAP
GAGPGVRRRQRSLEEIPRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGP
QMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQA
LNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAIC
YILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWN
AIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLM
AGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKE
TLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWL
RNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGEL
KSVARIVLVPNKKVGLQFLQRQC"
sig_peptide 22..120
/gene="CYP27"
/note="G00-128-129"
mat_peptide 121..1614
/gene="CYP27"
/product="sterol 27-hydroxylase"
/note="G00-128-129"
BASE COUNT 392 a 547 c 546 g 395 t
ORIGIN
1 gcaggcgcgc gagcacaacc catggctgcg ctgggctgcg cgaggctgag gtgggcgctg
61 cgaggggccg gccgtggcct ctgcccccac ggggccagag ccaaggccgc gatccctgcc
121 gccctcccct cggacaaggc caccggagct cccggagccg ggcctggtgt ccggcggcgg
181 caacggagct tagaggagat tccacgtcta ggacagctgc gcttcttctt tcagctgttc
241 gttcaaggct atgccctgca actgcaccag ttacaggtgc tttacaaggc caagtacggt
301 ccaatgtgga tgtcctactt agggcctcag atgcacgtga acctggccag tgccccgctc
361 ttggagcaag tgatgcggca agagggaaag tacccagtac ggaacgacat ggagctatgg
421 aaggagcacc gggaccagca cgacctgacc tatgggccgt tcaccacgga aggacaccac
481 tggtaccagc tgcgccaggc tctgaaccag cggttgctga agccagcgga agcagcgctc
541 tatacggatg ctttcaatga ggtgattgat gactttatga ctcgactgga ccagctgcgg
601 gcagagagtg cttcggggaa ccaggtgtcg gacatggctc aactcttcta ctactttgcc
661 ttggaagcta tttgctacat cctgttcgag aaacgcattg gctgcctgca gcgatccatc
721 cccgaggaca ccgtgacctt cgtcagatcc atcgggttaa tgttccagaa ctcactctat
781 gccaccttcc tccccaagtg gactcgcccc gtgctgcctt tctggaagcg atacctggat
841 ggttggaatg ccatcttttc ctttgggaag aagctgattg atgagaagct cgaagatatg
901 gaggcccaac tgcaggcagc agggccagat ggcatccagg tgtctggcta cctgcacttc
961 ttactggcca gtggacagct cagtcctcgg gaggccatgg gcagcctgcc tgagctgctc
1021 atggctggag tggacacgac atccaacacg ctgacatggg ccctgtacca cctctcaaag
1081 gaccctgaga tccaggaggc cttgcacgag gaagtggtgg gtgtggtgcc agccgggcaa
1141 gtgccccagc acaaggactt tgcccacatg ccgttgctca aagctgtgct taaggagact
1201 ctgcgtctct accctgtggt ccccacaaac tcccggatca tagaaaagga aattgaagtt
1261 gatggcttcc tcttccccaa gaacacccag tttgtgttct gccactatgt ggtgtcccgg
1321 gaccccactg ccttctctga gcctgaaagc ttccagcccc accgctggct gagaaacagc
1381 cagcctgcta cccccaggat ccagcaccca tttggctctg tgccctttgg ctatggggtc
1441 cgggcctgcc tgggccgcag gattgcagag ctggagatgc agctactcct cgcaaggctg
1501 atccagaagt acaaggtggt cctggccccg gagacggggg agttgaagag tgtggcccgc
1561 attgtcctgg ttcccaataa gaaagtgggc ctgcagttcc tgcagagaca gtgctgagct
1621 gagtctccgc cttgctgggg cttgtcctag aggctccagc tctggcacag tggttcctgg
1681 ctgctgccat gtctcagatg aggagggaga gaaggaggcc gccagactcg agaggtggga
1741 ggaactcctt gcacacaccc tgagcttttg ccacttctat catttttgag caactccctc
1801 tcagctaaaa ggccacccct ttatcgcatt gctgtccttg ggtagaatat aaaataaagg
1861 gacttttatt tcttaaaaaa
//