LOCUS       HUMCRCMUT               4181 bp    mRNA    linear   HUM 01-NOV-1994
DEFINITION  Human colorectal mutant cancer protein mRNA, complete cds.
ACCESSION   M62397
VERSION     M62397.1
KEYWORDS    colorectal cancer protein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4181)
  AUTHORS   Kinzler,K.W., Nilbert,M.C., Vogelstein,B., Bryan,T.M., Levy,D.B.,
            Smith,K.J., Preisinger,A.C., Hamilton,S.R., Nishisho,I., Miki,Y.,
            Miyoshi,Y. and Nakamura,Y.
  TITLE     Identification of a gene located at chromosome 5q21 that is mutated
            in colorectal cancers
  JOURNAL   Science 251 (4999), 1366-1370 (1991)
   PUBMED   1848370
COMMENT     Original source text: Human brain, cDNA to mRNA.
FEATURES             Location/Qualifiers
     source          1..4181
                     /db_xref="H-InvDB:HIT000196013"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="5q21-q22"
                     /tissue_type="brain"
     gene            1..4181
                     /gene="MCC"
     CDS             221..2710
                     /gene="MCC"
                     /codon_start=1
                     /product="colorectal mutant cancer protein"
                     /protein_id="AAA52069.1"
                     /db_xref="GDB:G00-128-163"
                     /translation="MNSGVAMKYGNDSSAELSELHSAALASLKGDIVELNKRLQQTER
                     ERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGT
                     TIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNS
                     ELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGR
                     DLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRR
                     VRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSK
                     TRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESK
                     IREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQ
                     YSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKT
                     AENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDE
                     QRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMA
                     MKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSL
                     SSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQEL
                     VSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMV
                     ERHETQVRMLKQRIALLEEENSRPHTNETSL"
BASE COUNT         1127 a         1039 c         1130 g          885 t
ORIGIN      Chromosome 5q21.
        1 cctcctgcag caatggctcg tccgtgaaac gcgagccacg gctgctcttt ttaagagtgc
       61 ctgcatcctc cgtttgcgct tcgcaactgt cctgggtgaa aatggctgtc tagactaaaa
      121 tgtggcagaa gggaccaagc agtggatatt gagcctgtga agtccaactc ttaagctccg
      181 agacctgggg gactgagagc ccagctctga aaagtgcatc atgaattccg gagttgccat
      241 gaaatatgga aacgactcct cggccgagct gagtgagctc cattcagcag ccctggcatc
      301 actaaaggga gatatagtgg aacttaataa acgtctccag caaacagaga gggaacggga
      361 ccttctggaa aagaaattgg ccaaggcaca gtgcgagcag tcccacctca tgagagagca
      421 tgaggatgtc caggagcgaa cgacgcttcg ctatgaggaa cgcatcacag agctccacag
      481 cgtcattgcg gagctcaaca agaagataga ccgtctgcaa ggcaccacca tcagggagga
      541 agatgagtac tcagaactgc gatcagaact cagccagagc caacacgagg tcaacgagga
      601 ctctcgaagc atggaccaag accagacctc tgtctctatc cccgaaaacc agtctaccat
      661 ggttactgct gacatggaca actgcagtga cctgaactca gaactgcaga gggtgctgac
      721 agggctggag aatgttgtct gcggcaggaa gaagagcagc tgcagcctct ccgtggccga
      781 ggtggacagg cacattgagc agctcaccac agccagcgag cactgtgacc tggctattaa
      841 gacagtcgag gagattgagg gggtgcttgg ccgggacctg tatcccaacc tggctgaaga
      901 gaggtctcgg tgggagaagg agctggctgg gctgagggaa gagaatgaga gcctgactgc
      961 catgctgtgc agcaaagagg aagaactgaa ccggactaag gccaccatga atgccatccg
     1021 ggaagagcgg gaccggctcc ggaggcgggt cagagagctt caaactcgac tacagagcgt
     1081 gcaggccaca ggtccctcca gccctggccg cctcacttcc accaaccgcc cgattaaccc
     1141 cagcactggg gagctgagca caagcagcag cagcaatgac attcccatcg ccaagattgc
     1201 tgagagggtg aagctatcaa agacaaggtc cgaatcgtca tcatctgatc ggccagtcct
     1261 gggctcagaa atcagtagca taggggtatc cagcagtgtg gctgaacacc tggcccactc
     1321 acttcaggac tgctccaata tccaagagat tttccaaaca ctctactcac acggatctgc
     1381 catctcagaa agcaagatta gagagtttga ggtggaaaca gaacggctga atagccggat
     1441 tgagcacctc aaatcccaaa atgacctcct gaccataacc ttggaggaat gtaaaagcaa
     1501 tgctgagagg atgagcatgc tggtgggaaa atacgaatcc aatgccacag cgctgaggct
     1561 ggccttgcag tacagcgagc agtgcatcga agcctacgaa ctcctcctgg cgctggcaga
     1621 gagtgagcag agcctcatcc tggggcagtt ccgagcggcg ggcgtggggt cctcccctgg
     1681 agaccagtcg ggggatgaaa acatcactca gatgctcaag cgagctcatg actgccggaa
     1741 gacagctgag aacgctgcca aggccctgct catgaagctg gacggcagct gtgggggagc
     1801 ctttgccgtg gccggctgca gcgtgcagcc ctgggagagc ctttcctcca acagccacac
     1861 cagcacaacc agctccacag ccagtagttg cgacaccgag ttcactaaag aagacgagca
     1921 gaggctgaag gattatatcc agcagctcaa gaatgacagg gctgcggtca agctgaccat
     1981 gctggagctg gaaagcatcc acatcgatcc tctcagctat gacgtcaagc ctcggggaga
     2041 cagccagagg ctggatctgg aaaacgcagt gcttatgcag gagctcatgg ccatgaagga
     2101 ggagatggcc gagttgaagg cccagctcta cctactggag aaagagaaga aggccctgga
     2161 gctgaagctg agcacgcggg aggcccagga gcaggcctac ctggtgcaca ttgagcacct
     2221 gaagtccgag gtggaggagc agaaggagca gcggatgcga tccctcagct ccaccagcag
     2281 cggcagcaaa gataaacctg gcaaggagtg tgctgatgct gcctccccag ctctgtccct
     2341 agctgaactc aggacaacgt gcagcgagaa tgagctggct gcggagttca ccaacgccat
     2401 tcgtcgagaa aagaagttga aggccagagt tcaagagctg gtgagtgcct tggagagact
     2461 caccaagagc agtgaaatcc gacatcagca atctgcagag ttcgtgaatg atctaaagcg
     2521 ggccaacagc aacctggtgg ctgcctatga gaaagcaaag aaaaagcatc aaaacaaact
     2581 gaagaagtta gagtcgcaga tgatggccat ggtggagaga catgagaccc aagtgaggat
     2641 gctcaagcaa agaatagctc tgctagagga ggagaactcc aggccacaca ccaatgaaac
     2701 ttcgctttaa tcagcactca cgcaccggag ttctgcccat gggaagtaaa ctgcagcagg
     2761 ccactgggga cagaagggcc catgtacttg ttgggaggag gaggaaaggg aaggctggca
     2821 ggtaggtcgg cacttggaca atggagtgcc ccaactcaac ccttggggtg actggccatg
     2881 gtgacattgt ggactgtatc cagaggtgcc cgctcttccc tcctgggccc acaacagcgt
     2941 gtaaacacat gttctgtgcc tgctcagcag agcctcgttt ctgctttcag cactcactct
     3001 ccccctcctc ttctggtctg gcggctgtgc atcagtggga tcccagacat ttgtttctgt
     3061 aagattttcc attgtatcct ctttttggta gatgctgggc tcatcttcta gaatctcgtt
     3121 tctcctcttt cctcctgctt catgggaaaa cagacctgtg tgtgcctcca gcatttaaaa
     3181 ggactgctga tttgtttact acagcaaggc tttggtttcc aagtcccggg tctcaacttt
     3241 aagatagagg cggccataag aggtgatctc tgggagttat aggtcatggg aagagcgtag
     3301 acaggtgtta cttacagtcc cagatacact aaagttacaa acagaccacc accaggactg
     3361 tgcctgaaca attttgtatt gagagaataa aaacttcctt caatcttcat tttggaggca
     3421 gggctgggaa gggagcgctc tcttgattct gggatttctc cctctcagtg gagccttatt
     3481 aatatccaag acttagagct gggaatcttt ttgatacctg tagtggaact aaaattctgt
     3541 caggggtttc ttcaagagct gagaaacatt attagcactt cccgccccag ggcactacat
     3601 aattgctgtt ctgctgaatc aaatctcttc cacatgggtg catttgtagc tctggacctg
     3661 tctctaccta aggacaagac actgaggaga tactgaacat tttgcaaaac ttatcacgcc
     3721 tacttaagag tgctgtgtaa cccccagttc aagacttagc tcctgttgtc atgacgggga
     3781 cagagtgagg gaatggtagt taaggcttct tttttgcccc cagatacatg gtgatggtta
     3841 gcatatggtg cttaaaaggt taaatttcaa gcaaaatgct tacagggcta ggcagtacca
     3901 aagtaactga attatttcag gaaggtcttc aatcttaaaa caaattcatt attctttttc
     3961 agttttacct cttctctctc agttctacac tgatacactt gaaggaccat ttactgtttt
     4021 tttctgtagc accagagaat ccatccaaag ttccctatga aaaatgtgtt ccattgccat
     4081 agctgactac aaattaaagt tgaggaggtt tctgcataga gtctttatgt ccataagcta
     4141 cgggtaggtc tattttcaga gcatgataca aattccacag g
//