LOCUS HUMCRCMUT 4181 bp mRNA linear HUM 01-NOV-1994 DEFINITION Human colorectal mutant cancer protein mRNA, complete cds. ACCESSION M62397 VERSION M62397.1 KEYWORDS colorectal cancer protein. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4181) AUTHORS Kinzler,K.W., Nilbert,M.C., Vogelstein,B., Bryan,T.M., Levy,D.B., Smith,K.J., Preisinger,A.C., Hamilton,S.R., Nishisho,I., Miki,Y., Miyoshi,Y. and Nakamura,Y. TITLE Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers JOURNAL Science 251 (4999), 1366-1370 (1991) PUBMED 1848370 COMMENT Original source text: Human brain, cDNA to mRNA. FEATURES Location/Qualifiers source 1..4181 /db_xref="H-InvDB:HIT000196013" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="5q21-q22" /tissue_type="brain" gene 1..4181 /gene="MCC" CDS 221..2710 /gene="MCC" /codon_start=1 /product="colorectal mutant cancer protein" /protein_id="AAA52069.1" /db_xref="GDB:G00-128-163" /translation="MNSGVAMKYGNDSSAELSELHSAALASLKGDIVELNKRLQQTER ERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGT TIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNS ELQRVLTGLENVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGR DLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRR VRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSK TRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESK IREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQ YSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKT AENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDE QRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMA MKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSL SSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQEL VSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMV ERHETQVRMLKQRIALLEEENSRPHTNETSL" BASE COUNT 1127 a 1039 c 1130 g 885 t ORIGIN Chromosome 5q21. 1 cctcctgcag caatggctcg tccgtgaaac gcgagccacg gctgctcttt ttaagagtgc 61 ctgcatcctc cgtttgcgct tcgcaactgt cctgggtgaa aatggctgtc tagactaaaa 121 tgtggcagaa gggaccaagc agtggatatt gagcctgtga agtccaactc ttaagctccg 181 agacctgggg gactgagagc ccagctctga aaagtgcatc atgaattccg gagttgccat 241 gaaatatgga aacgactcct cggccgagct gagtgagctc cattcagcag ccctggcatc 301 actaaaggga gatatagtgg aacttaataa acgtctccag caaacagaga gggaacggga 361 ccttctggaa aagaaattgg ccaaggcaca gtgcgagcag tcccacctca tgagagagca 421 tgaggatgtc caggagcgaa cgacgcttcg ctatgaggaa cgcatcacag agctccacag 481 cgtcattgcg gagctcaaca agaagataga ccgtctgcaa ggcaccacca tcagggagga 541 agatgagtac tcagaactgc gatcagaact cagccagagc caacacgagg tcaacgagga 601 ctctcgaagc atggaccaag accagacctc tgtctctatc cccgaaaacc agtctaccat 661 ggttactgct gacatggaca actgcagtga cctgaactca gaactgcaga gggtgctgac 721 agggctggag aatgttgtct gcggcaggaa gaagagcagc tgcagcctct ccgtggccga 781 ggtggacagg cacattgagc agctcaccac agccagcgag cactgtgacc tggctattaa 841 gacagtcgag gagattgagg gggtgcttgg ccgggacctg tatcccaacc tggctgaaga 901 gaggtctcgg tgggagaagg agctggctgg gctgagggaa gagaatgaga gcctgactgc 961 catgctgtgc agcaaagagg aagaactgaa ccggactaag gccaccatga atgccatccg 1021 ggaagagcgg gaccggctcc ggaggcgggt cagagagctt caaactcgac tacagagcgt 1081 gcaggccaca ggtccctcca gccctggccg cctcacttcc accaaccgcc cgattaaccc 1141 cagcactggg gagctgagca caagcagcag cagcaatgac attcccatcg ccaagattgc 1201 tgagagggtg aagctatcaa agacaaggtc cgaatcgtca tcatctgatc ggccagtcct 1261 gggctcagaa atcagtagca taggggtatc cagcagtgtg gctgaacacc tggcccactc 1321 acttcaggac tgctccaata tccaagagat tttccaaaca ctctactcac acggatctgc 1381 catctcagaa agcaagatta gagagtttga ggtggaaaca gaacggctga atagccggat 1441 tgagcacctc aaatcccaaa atgacctcct gaccataacc ttggaggaat gtaaaagcaa 1501 tgctgagagg atgagcatgc tggtgggaaa atacgaatcc aatgccacag cgctgaggct 1561 ggccttgcag tacagcgagc agtgcatcga agcctacgaa ctcctcctgg cgctggcaga 1621 gagtgagcag agcctcatcc tggggcagtt ccgagcggcg ggcgtggggt cctcccctgg 1681 agaccagtcg ggggatgaaa acatcactca gatgctcaag cgagctcatg actgccggaa 1741 gacagctgag aacgctgcca aggccctgct catgaagctg gacggcagct gtgggggagc 1801 ctttgccgtg gccggctgca gcgtgcagcc ctgggagagc ctttcctcca acagccacac 1861 cagcacaacc agctccacag ccagtagttg cgacaccgag ttcactaaag aagacgagca 1921 gaggctgaag gattatatcc agcagctcaa gaatgacagg gctgcggtca agctgaccat 1981 gctggagctg gaaagcatcc acatcgatcc tctcagctat gacgtcaagc ctcggggaga 2041 cagccagagg ctggatctgg aaaacgcagt gcttatgcag gagctcatgg ccatgaagga 2101 ggagatggcc gagttgaagg cccagctcta cctactggag aaagagaaga aggccctgga 2161 gctgaagctg agcacgcggg aggcccagga gcaggcctac ctggtgcaca ttgagcacct 2221 gaagtccgag gtggaggagc agaaggagca gcggatgcga tccctcagct ccaccagcag 2281 cggcagcaaa gataaacctg gcaaggagtg tgctgatgct gcctccccag ctctgtccct 2341 agctgaactc aggacaacgt gcagcgagaa tgagctggct gcggagttca ccaacgccat 2401 tcgtcgagaa aagaagttga aggccagagt tcaagagctg gtgagtgcct tggagagact 2461 caccaagagc agtgaaatcc gacatcagca atctgcagag ttcgtgaatg atctaaagcg 2521 ggccaacagc aacctggtgg ctgcctatga gaaagcaaag aaaaagcatc aaaacaaact 2581 gaagaagtta gagtcgcaga tgatggccat ggtggagaga catgagaccc aagtgaggat 2641 gctcaagcaa agaatagctc tgctagagga ggagaactcc aggccacaca ccaatgaaac 2701 ttcgctttaa tcagcactca cgcaccggag ttctgcccat gggaagtaaa ctgcagcagg 2761 ccactgggga cagaagggcc catgtacttg ttgggaggag gaggaaaggg aaggctggca 2821 ggtaggtcgg cacttggaca atggagtgcc ccaactcaac ccttggggtg actggccatg 2881 gtgacattgt ggactgtatc cagaggtgcc cgctcttccc tcctgggccc acaacagcgt 2941 gtaaacacat gttctgtgcc tgctcagcag agcctcgttt ctgctttcag cactcactct 3001 ccccctcctc ttctggtctg gcggctgtgc atcagtggga tcccagacat ttgtttctgt 3061 aagattttcc attgtatcct ctttttggta gatgctgggc tcatcttcta gaatctcgtt 3121 tctcctcttt cctcctgctt catgggaaaa cagacctgtg tgtgcctcca gcatttaaaa 3181 ggactgctga tttgtttact acagcaaggc tttggtttcc aagtcccggg tctcaacttt 3241 aagatagagg cggccataag aggtgatctc tgggagttat aggtcatggg aagagcgtag 3301 acaggtgtta cttacagtcc cagatacact aaagttacaa acagaccacc accaggactg 3361 tgcctgaaca attttgtatt gagagaataa aaacttcctt caatcttcat tttggaggca 3421 gggctgggaa gggagcgctc tcttgattct gggatttctc cctctcagtg gagccttatt 3481 aatatccaag acttagagct gggaatcttt ttgatacctg tagtggaact aaaattctgt 3541 caggggtttc ttcaagagct gagaaacatt attagcactt cccgccccag ggcactacat 3601 aattgctgtt ctgctgaatc aaatctcttc cacatgggtg catttgtagc tctggacctg 3661 tctctaccta aggacaagac actgaggaga tactgaacat tttgcaaaac ttatcacgcc 3721 tacttaagag tgctgtgtaa cccccagttc aagacttagc tcctgttgtc atgacgggga 3781 cagagtgagg gaatggtagt taaggcttct tttttgcccc cagatacatg gtgatggtta 3841 gcatatggtg cttaaaaggt taaatttcaa gcaaaatgct tacagggcta ggcagtacca 3901 aagtaactga attatttcag gaaggtcttc aatcttaaaa caaattcatt attctttttc 3961 agttttacct cttctctctc agttctacac tgatacactt gaaggaccat ttactgtttt 4021 tttctgtagc accagagaat ccatccaaag ttccctatga aaaatgtgtt ccattgccat 4081 agctgactac aaattaaagt tgaggaggtt tctgcataga gtctttatgt ccataagcta 4141 cgggtaggtc tattttcaga gcatgataca aattccacag g //