LOCUS HUMSPTA01 8001 bp mRNA linear HUM 13-JAN-1995
DEFINITION Human erythroid alpha-spectrin (SPTA1) mRNA, complete cds.
ACCESSION M61877 J05244
VERSION M61877.1
KEYWORDS alpha-spectrin; erythroid alpha-spectrin; spectrin.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8001)
AUTHORS Sahr,K.E., Laurila,P., Kotula,L., Scarpa,A.L., Coupal,E.,
Leto,T.L., Linnenbach,A.J., Winkelmann,J.C., Speicher,D.W.,
Marchesi,V.T., Curtis,P.J. and Forget,B.G.
TITLE The complete cDNA and polypeptide sequences of human erythroid
alpha-spectrin
JOURNAL J. Biol. Chem. 265 (8), 4434-4443 (1990)
PUBMED 1689726
REFERENCE 2 (sites)
AUTHORS Hentati,A., Hu,P., Asgharzadeh,S. and Siddique,T.
TITLE Dinucleotide repeat polymorphism at the human erythroid alpha
spectrin (SPTA1) locus
JOURNAL Hum. Mol. Genet. 1 (3), 218 (1992)
PUBMED 1339473
COMMENT Original source text: Homo sapiens RNA.
Draft entry and computer-readable sequence for [1] kindly submitted
by B.G.Forget, 26-JAN-1990.
From EMBL entry HSSPTA01; dated 16-FEB-1991.
FEATURES Location/Qualifiers
source 1..8001
/db_xref="H-InvDB:HIT000196000"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="1q21"
gene 1..8001
/gene="SPTA1"
CDS 187..7476
/gene="SPTA1"
/codon_start=1
/product="erythroid alpha spectrin"
/protein_id="AAA60577.1"
/db_xref="GDB:G00-119-601"
/translation="MEQFPKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAE
RGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQ
TKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKF
QQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVN
QYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEA
IQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSH
PSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAA
INADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREK
MEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSL
GSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDA
LREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQ
VFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQ
LHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQ
DQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLI
CRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERG
NKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETW
IREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAP
VEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVY
VRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLA
YEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLF
EGLLTPEGAQIRQELNARWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQ
ALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQR
QKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAED
LTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERD
DLEKAWEKRKKILDQCLELQMFQGNCDQVESRMVARENSLRSDDKSSLDSLEALMKKR
DDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERT
KLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRS
EQVHGVINLGNSLIERSCDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQR
FNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTL
AEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEES
WIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAV
GQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAV
RGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLHEESQNKEISS
KIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGAD
LGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRW
EQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSL
NEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKH
LSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGT
LESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLG
LRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYL
PMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENAFQALA
EGKSYITKEDMKQALTPEQVSFCATHMQQYMDPRVEAISLAMTTLASPIPTLATNKQL
LVDRRKS"
BASE COUNT 2393 a 1619 c 2173 g 1816 t
ORIGIN
1 tgtcgattgt gtatggctga tgggattcta ggaccaagca agaggttttt tttttttccc
61 ccacatactt aacgtttcta tatttctatt tgaattcgac tggacagttc catttgaatt
121 atttctctct ctctctctct ctctctgaca cattttatct tgccaggttc taaaccttta
181 ggaaaaatgg agcaatttcc aaaggaaacc gttgtggaga gcagtgggcc aaaggttttg
241 gaaacagcag aagagatcca ggagaggcgt caggaagtgt tgactcggta tcaaagtttc
301 aaggagcggg ttgctgagag gggtcagaag cttgaggatt cctatcactt acaagttttc
361 aagcgagatg cagatgatct ggggaagtgg atcatggaga aagtcaatat cttaaccgat
421 aagagctatg aagacccaac taatatacag gggaaatatc agaagcatca atcccttgaa
481 gcagaggtgc aaacgaaatc aagactcatg tctgaactgg aaaaaacaag ggaagaacga
541 tttaccatgg gtcattctgc ccacgaagaa acgaaggccc atatagagga gctacgccac
601 ctgtgggacc tgctgttaga gctgaccctg gagaagggtg accagttgct gcgggccctg
661 aagttccagc agtatgtaca ggagtgtgct gacatcttag agtggattgg agacaaggag
721 gctatagcga catcagtgga gctaggtgaa gactgggagc gcaccgaagt tctgcataag
781 aaatttgaag acttccaagt ggagctggta gctaaagaag ggagagttgt tgaagtgaac
841 caatatgcca atgagtgtgc cgaggaaaac catcctgacc tacccttaat tcagtctaag
901 caaaatgagg tgaatgctgc ctgggagcgc cttcgtggtt tggctctcca gagacagaaa
961 gctctgtcca atgctgcaaa cttacaacga ttcaaaaggg atgtgactga agccatccag
1021 tggatcaagg agaaggaacc tgtactcacc tctgaggact atggcaaaga ccttgttgcc
1081 tctgaaggac tgtttcacag ccacaaggga cttgagagaa atcttgcagt catgagtgac
1141 aaggtgaagg agttatgtgc taaagcagag aagctgacac tttcccatcc ttcagatgca
1201 cctcagatcc aggagatgaa agaagatctg gtctccagct gggagcatat tcgtgccctg
1261 gccaccagca gatatgaaaa actgcaggct acttattggt accatcgatt ttcatctgac
1321 tttgatgaac tctcaggctg gatgaacgag aagactgctg cgatcaatgc tgatgagctg
1381 ccaacagatg tggctggtgg agaagttctg ctggacaggc atcagcagca taagcatgag
1441 attgactctt acgatgaccg atttcaatct gctgatgaga ctggtcaaga cctcgtgaat
1501 gccaatcatg aagcctctga tgaagttcgg gaaaagatgg aaatacttga caacaactgg
1561 actgccctgc tggaactgtg ggacgagcgt catcgtcagt atgagcagtg cttggacttt
1621 catctcttct acagagacag tgagcaagtg gacagttgga tgagtagaca agaggccttc
1681 ctggaaaacg aggatctggg aaactcactg ggcagtgcag aagcccttct tcagaagcat
1741 gaagactttg aggaagcctt tactgcccag gaagagaaga tcataactgt agacaagact
1801 gcaaccaaat tgattggtga tgaccattat gattcagaga acatcaaggc tatccgtgac
1861 ggcctgttag cccggcggga tgccctacgt gaaaaggctg ccactagacg tagattgctg
1921 aaggagtcat tgcttctgca aaaactgtat gaggactcag atgacctaaa gaactggatc
1981 aacaagaaga aaaagttggc agatgatgaa gattacaagg acatacagaa cttgaagagc
2041 agggttcaaa agcagcaagt ctttgaaaag gagttggcag ttaataagac ccagctggaa
2101 aacatacaga aaactggcca agagatgatt gagggtggtc actatgcctc tgacaatgtg
2161 accactcgtc tgagtgaagt tgccagcctc tgggaggagt tgctggaggc tacaaaacag
2221 aaagggaccc agttgcatga ggccaaccag cagctgcaat ttgaaaataa tgcagaagat
2281 ttgcagcgct ggctggagga tgttgagtgg caagtcacct ctgaggatta tgggaaaggc
2341 ctggccgagg tacagaatcg actcaggaaa cacggcctcc tggagtcggc tgtggctgct
2401 cgtcaggatc aggtggatat ccttacagac ctggctgcat attttgaaga aataggccat
2461 cctgattcta aggatataag ggcaaggcaa gagtccttgg tatgccgatt tgaagctctg
2521 aaagagccac tggccacccg aaagaagaag ctcttagacc ttctccatct gcagctgatt
2581 tgtagagaca cagaggatga ggaggcctgg atccaagaga ctgaaccctc agctacttcc
2641 acctaccttg gaaaggacct gattgcttcc aaaaagcttc tgaataggca tagagtcatc
2701 ctggagaaca ttgccagcca tgaaccacgc attcaagaga taacagaaag gggaaacaaa
2761 atggtagagg aaggacactt tgctgcagaa gatgtggcct ctagggtcaa gagtttgaac
2821 cagaatatgg agtctctccg tgctcgagct gctaggcgac aaaatgatct tgaagccaat
2881 gtccagttcc agcagtacct ggctgacctg catgaagcag aaacatggat cagagagaag
2941 gaacctattg tagataatac taactatggt gctgatgaag aagcagctgg ggctcttcta
3001 aagaagcatg aggcctttct attagatctc aattcatttg gagacagtat gaaagctctg
3061 cggaatcagg caaacgcctg ccagcaacaa caggctgcac cagtggaggg agttgctgga
3121 gaacaaaggg tcatggcttt atatgacttc caggcccgca gcccccgaga agtcaccatg
3181 aagaaaggtg atgtcttaac gctgctcagt tccatcaata aggactggtg gaaggtggaa
3241 gctgctgatc atcagggcat tgtcccagct gtctatgtca gaagactggc ccacgatgag
3301 ttcccgatgc tcccacagcg gcgacgagaa gagccaggaa acatcaccca gcgccaggag
3361 cagattgaga accaataccg ctccctcttg gatcgggcag aagaacgcag acgtcgtcta
3421 ttgcaacgtt ataatgaatt tttattggcc tatgaggcag gagacatgct ggaatggatt
3481 caagagaaaa aggcagaaaa cactggagtg gaactagatg atgtttggga gctgcagaaa
3541 aagtttgatg agttccaaaa ggatttgaat accaatgagc ctcggctaag ggatatcaac
3601 aaggtagctg atgatctact atttgaagga cttctaacac cagaaggagc tcaaatccgg
3661 caggaattga atgcccgctg gggttctttg cagaggcttg cagatgaaca gcggcagctg
3721 ctgggcagtg cccatgctgt tgaagtgttt cacagagaag cagatgacac gaaggagcag
3781 attgagaaga aatgccaggc cctcagtgct gcagaccctg gctcagatct gttcagtgtt
3841 caggctcttc agcgacggca tgagggcttt gaaagggacc tcgtacccct gggagataag
3901 gtgaccatac tgggggagac agcagagcgg ctcagtgagt cccatccaga tgccactgag
3961 gacctgcaga gacagaaaat ggagctgaat gaggcctggg aagacctgca ggggcgtaca
4021 aaggatcgta aggagagcct aaatgaggcc cagaaattct acctgttcct cagcaaggcc
4081 agggatctgc agaactggat cagtagcatt ggtggcatgg tatcatcaca ggagctggcc
4141 gaagacttaa ctggcataga gatcttgctg gagagacatc aggagcaccg tgctgacatg
4201 gaggcagagg ctcccacctt ccaggcctta gaggacttca gtgcagaact tatcgacagt
4261 gggcaccatg ctagccctga aattgaaaaa aagcttcaag ctgtcaagct agagagagat
4321 gatttggaga aggcttggga aaaacgcaag aagatcctag accagtgcct ggagttgcag
4381 atgttccagg ggaactgtga tcaagttgag agccggatgg tggcacgtga gaattccctg
4441 aggtcagatg acaaaagttc cttagacagt ctggaggctt tgatgaagaa acgggacgat
4501 ttggacaaag caatcactgc ccaggaaggg aagatcactg acctagaaca ttttgctgag
4561 agcctcattg ctgatgaaca ctatgccaaa gaagagattg ctacgcggct ccaacgtgta
4621 ctagacaggt ggaaggctct caaagcacaa ctgattgatg agcggacaaa gcttggagac
4681 tatgccaacc taaaacaatt ctaccgagac cttgaggagc tggaagaatg gatcagtgag
4741 atgctgccca cagcctgtga tgaatcctac aaagacgcca ctaacattca gaggaaatac
4801 ctgaaacacc agacctttgc acatgaagtc gatggccgat ctgagcaggt gcatggcgtc
4861 atcaacctgg ggaactccct gattgagcgt agttgtgatg gcaatgaaga ggccatgaag
4921 gagcaactgg aacagctgaa ggaacattgg gatcatctgc ttgagagaac aaatgacaaa
4981 gggaagaagc tcaatgaggc cagtcgtcaa cagaggttca acacaagcat ccgggacttt
5041 gagttctggc tctcagaggc agagacattg ctggccatga aagatcaggc cagggacttg
5101 gcttcagcag gaaacctact caagaagcat cagctattgg agagagagat gttggctcga
5161 gaggatgcac tcaaggacct gaatacattg gctgaagatt tgctctccag cgggactttc
5221 aacgttgatc agattgtgaa gaaaaaagat aatgtcaaca agcgtttcct gaatgtccaa
5281 gaattggcag ctgcacacca cgaaaaattg aaagaggcct atgccttgtt ccagttcttc
5341 caggatctag atgatgagga atcctggata gaggagaagt tgatacgagt gagctcccag
5401 gactatggga gagatcttca gggggttcag aacttgctga agaagcacaa acgcctagag
5461 ggggagctgg tggcccatga gcctgccatc cagaatgtgc tggatatggc agagaagctg
5521 aaagacaagg ctgctgtggg gcaagaggag atccagttgc ggctggctca gtttgttgaa
5581 cactgggaga agctcaaaga gttggccaag gcccgaggac ttaagttgga agaatcccta
5641 gaatacttgc aattcatgca gaatgctgag gaagaggaag cttggatcaa tgaaaagaat
5701 gctttggctg tccgaggaga ttgtggagat acattagctg ctactcagag cttgctaatg
5761 aagcatgaag ctttggaaaa tgactttgct gtccatgaga cccgagtaca aaatgtgtgt
5821 gcacaaggag aagacatcct aaataaggtg ttgcatgagg aaagtcagaa caaagagatt
5881 tcttccaaga tagaggctct gaatgaaaag accccttctc tggctaaggc aatagctgct
5941 tggaagttgc aattggaaga cgattatgcc tttcaggaat tcaactggaa ggctgatgtg
6001 gtagaggctt ggatagctga taaggaaaca agcctaaaga ccaatggcaa tggtgcagac
6061 cttggtgact tcctcactct tctggcaaaa caggacactc tggatgccag tctgcagagt
6121 ttccagcaag agagacttcc cgagatcact gacctgaagg acaaactgat ttctgctcaa
6181 cacaaccagt ctaaagccat tgaagagcgt tatgccgctc tgctgaagcg ctgggaacag
6241 ttgctggaag cctcggcagt ccacagacag aaattgctgg agaaacagct gcctctacag
6301 aaggctgagg acctgttcgt ggaatttgca cataaggctt cagctttgaa caactggtgt
6361 gaaaagatgg aagaaaactt gtcagagcct gtgcactgtg tctccctgaa tgaaattcgg
6421 cagctgcaga aagaccatga ggacttcttg gcctccctgg ctagggctca agcagacttt
6481 aaatgtttgc tggagctaga ccagcagatt aaggccttag gtgtgccttc cagcccttat
6541 acctggttaa cagtggaggt gctggaaagg acctggaagc acctatctga catcattgag
6601 gaacgggagc aggagctgca aaaggaagag gcaagacagg tcaagaactt tgagatgtgt
6661 caggagtttg aacagaatgc cagtaccttc cttcaatgga tcctggaaac cagggcttac
6721 tttctggatg gatcattgct caaagaaaca ggaactctgg aatctcagct ggaagcaaat
6781 aaaagaaaac agaaggagat ccaggcgatg aagcgtcaac taaccaagat tgtggacctg
6841 ggggacaact tggaagacgc tctgatcctt gatatcaaat acagcaccat tggattggct
6901 cagcagtggg accagctcta ccagcttggg ttgcggatgc aacacaacct ggagcaacag
6961 atccaggcca aggacatcaa aggtgtgagt gaagagactc taaaggaatt tagcacaatc
7021 tataaacact ttgatgagaa tttgacaggg cgcctgactc acaaagagtt ccggtcctgc
7081 ctgagaggac tcaattacta cttgcccatg gtggaggagg atgaacatga gcccaagttt
7141 gagaagttcc tggatgctgt ggatccaggg aggaagggct atgtctcact ggaggactat
7201 actgctttcc tgattgacaa ggagtcagaa aacatcaagt ccagtgatga aatagagaat
7261 gccttccaag ccctggcaga gggcaagtca tatattacca aagaagacat gaagcaggcc
7321 cttaccccag agcaagtgtc attctgtgcc acacatatgc agcaatatat ggacccacgg
7381 gtcgaagcca tctctctggc tatgactacg ttggcttcac caattcctac tttggcaact
7441 aataagcagc tcctcgtgga tcgtagaaaa tcttagtgtc gtgggaaatt tactgggggg
7501 caaagagtac aggcaaatgt ggaagataaa gatggcctcg tgtgtgtgtg tgtgtgtgtg
7561 tgtgtgtgtg tgtgcttgtg tttgtgtgca tattacattt attgtaggat ctttaaaaaa
7621 tctcaagggt gggagataga aaggttaata gagttggagg agtggaagct attttgtatg
7681 caactagtca ctgctgaggg gtgtcaaagt ttctattttt atttgttctg ttttgcacgt
7741 ctttatcatt ttcctttatt ccgattatag aataaagtaa ttctttttaa aaatattttt
7801 tggggcaaag ttaagtaaaa tgttgagctt ctatatttct gggaactgta ctcatataag
7861 agtgggcagc taattttact gtaaagaagg gccatggtat agtagataaa taaaatccaa
7921 ggcaattttc aaacaatttt tttaaacttt ggaatgtgtt taaatttaaa tttgaaaata
7981 aagatatttg attttctggg g
//