LOCUS HUMNF1A 1197 bp mRNA linear HUM 07-JAN-1995
DEFINITION Human neurofibromatosis protein type I (NF1) mRNA, complete cds.
ACCESSION M60915
VERSION M60915.1
KEYWORDS neurofibromatosis protein type 1.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1197)
AUTHORS Nishi,T., Lee,P.S., Oka,K., Levin,V.A., Tanase,S., Morino,Y. and
Saya,H.
TITLE Differential expression of two types of the neurofibromatosis type
1 (NF1) gene transcripts related to neuronal differentiation
JOURNAL Oncogene 6 (9), 1555-1559 (1991)
PUBMED 1923522
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1197
/db_xref="H-InvDB:HIT000195970"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="VA13"
gene join(1..609,673..1197)
/gene="NF1"
CDS 1..1197
/codon_start=1
/product="neurofibromatosis protein type 1"
/protein_id="AAA59921.1"
/translation="GYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLADRFERLVEL
VTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELAD
SMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEVDPTRLE
PSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEK
KENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMS
KILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISD
GNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHW
SSLNLTS"
CDS join(1..609,673..1197)
/gene="NF1"
/note="protein obtained by alternative splicing (bases
610-672 are not included in this protein)."
/codon_start=1
/product="neurofibromatosis protein type 1"
/protein_id="AAA59922.1"
/translation="GYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLADRFERLVEL
VTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELAD
SMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEVDPTRLE
PSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQNSIGAVG
SAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEEHMRPF
NDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQYL
SSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTS"
BASE COUNT 353 a 270 c 249 g 325 t
ORIGIN Chromosome 17q11.
1 ggttaccaca aggatctcca gacaagagct acatttatgg aagttctgac aaaaatcctt
61 caacaaggca cagaatttga cacacttgca gaaacagtat tggctgatcg gtttgagaga
121 ttggtggaac tggtcacaat gatgggtgat caaggagaac tccctatagc gatggctctg
181 gccaatgtgg ttccttgttc tcagtgggat gaactagctc gagttctggt tactctgttt
241 gattctcggc atttactcta ccaactgctc tggaacatgt tttctaaaga agtagaattg
301 gcagactcca tgcagactct cttccgaggc aacagcttgg ccagtaaaat aatgacattc
361 tgtttcaagg tatatggtgc tacctatcta caaaaactcc tggatccttt attacgaatt
421 gtgatcacat cctctgattg gcaacatgtt agctttgaag tggatcctac caggttagaa
481 ccatcagaga gccttgagga aaaccagcgg aacctccttc agatgactga aaagttcttc
541 catgccatca tcagttcctc ctcagaattc ccccctcaac ttcgaagtgt gtgccactgt
601 ttataccagg caacttgcca ctccctactg aataaagcta cagtaaaaga aaaaaaggaa
661 aacaaaaaat cagtggttag ccagcgtttc cctcagaaca gcatcggtgc agtaggaagt
721 gccatgttcc tcagatttat caatcctgcc attgtctcac cgtatgaagc agggatttta
781 gataaaaagc caccacctag aatcgaaagg ggcttgaagt taatgtcaaa gatacttcag
841 agtattgcca atcatgttct cttcacaaaa gaagaacata tgcggccttt caatgatttt
901 gtgaaaagca actttgatgc agcacgcagg tttttccttg atatagcatc tgattgtcct
961 acaagtgatg cagtaaatca tagtctttcc ttcataagtg acggcaatgt gcttgcttta
1021 catcgtctac tctggaacaa tcaggagaaa attgggcagt atctttccag caacagggat
1081 cataaagctg ttggaagacg accttttgat aagatggcaa cacttcttgc atacctgggt
1141 cctccagagc acaaacctgt ggcagataca cactggtcca gccttaacct taccagt
//