LOCUS HUMMGDMT 744 bp mRNA linear HUM 07-JAN-1995 DEFINITION Human O-6-methylguanine-DNA methyltransferase mRNA, complete cds. ACCESSION M60761 VERSION M60761.1 KEYWORDS O-6-methylguanine-DNA methyltransferase. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 744) AUTHORS Koike,G., Maki,H., Takeya,H., Hayakawa,H. and Sekiguchi,M. TITLE Purification, structure, and biochemical properties of human O6-methylguanine-DNA methyltransferase JOURNAL J. Biol. Chem. 265 (25), 14754-14762 (1990) PUBMED 2394694 REFERENCE 2 (sites) AUTHORS Hayakawa,H., Koike,G. and Sekiguchi,M. TITLE Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA JOURNAL J. Mol. Biol. 213 (4), 739-747 (1990) PUBMED 2359121 COMMENT Original source text: Homo sapiens cDNA to mRNA. FEATURES Location/Qualifiers source 1..744 /db_xref="H-InvDB:HIT000195961" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="10q24.33-qter" /cell_line="Raji" gene 1..744 /gene="MGMT" CDS 16..639 /gene="MGMT" /codon_start=1 /product="O-6-methylguanine-DNA methyltransferase" /protein_id="AAA59594.1" /db_xref="GDB:G00-125-264" /translation="MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAV EVPAPAAVLGGPEPLMQCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKL LKVVKFGEVISYQQLAALAGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSG GLAVKEWLLAHEGHRLGKPGLGGSSGLAGAWLKGAGATSGSPPAGRN" polyA_site 744 /gene="MGMT" /note="G00-125-264" BASE COUNT 162 a 194 c 246 g 142 t ORIGIN 1 ttggtacttg gaaaaatgga caaggattgt gaaatgaaac gcaccacact ggacagccct 61 ttggggaagc tggagctgtc tggttgtgag cagggtctgc acgaaataaa gctcctgggc 121 aaggggacgt ctgcagctga tgccgtggag gtcccagccc ccgctgcggt tctcggaggt 181 ccggagcccc tgatgcagtg cacagcctgg ctgaatgcct atttccacca gcccgaggct 241 atcgaagagt tccccgtgcc ggcacttcac catcccgttt tccagcaaga gtcgttcacc 301 agacaggtgt tatggaagct gctgaaggtt gtgaaattcg gagaagtgat ttcttaccag 361 caattagcag ccctggcagg caaccccaaa gccgcgcgag cagtgggagg agcaatgaga 421 ggcaatcctg tccccatcct catcccgtgc cacagagtgg tctgcagcag cggagccgtg 481 ggcaactact ccggaggact ggccgtgaag gaatggcttc tggcccatga aggccaccgg 541 ttggggaagc caggcttggg agggagctca ggtctggcag gggcctggct caagggagcg 601 ggagctacct cgggctcccc gcctgctggc cgaaactgag tatgtgcagt aggatggatg 661 tttgagcgac acacacgtgt aacactgcat cggatgcggg gcgtggaggc accgctgtat 721 taaaggaagt ggcagtgtcc tggg //