LOCUS       HUMMGDMT                 744 bp    mRNA    linear   HUM 07-JAN-1995
DEFINITION  Human O-6-methylguanine-DNA methyltransferase mRNA, complete cds.
ACCESSION   M60761
VERSION     M60761.1
KEYWORDS    O-6-methylguanine-DNA methyltransferase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 744)
  AUTHORS   Koike,G., Maki,H., Takeya,H., Hayakawa,H. and Sekiguchi,M.
  TITLE     Purification, structure, and biochemical properties of human
            O6-methylguanine-DNA methyltransferase
  JOURNAL   J. Biol. Chem. 265 (25), 14754-14762 (1990)
   PUBMED   2394694
REFERENCE   2  (sites)
  AUTHORS   Hayakawa,H., Koike,G. and Sekiguchi,M.
  TITLE     Expression and cloning of complementary DNA for a human enzyme that
            repairs O6-methylguanine in DNA
  JOURNAL   J. Mol. Biol. 213 (4), 739-747 (1990)
   PUBMED   2359121
COMMENT     Original source text: Homo sapiens cDNA to mRNA.
FEATURES             Location/Qualifiers
     source          1..744
                     /db_xref="H-InvDB:HIT000195961"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="10q24.33-qter"
                     /cell_line="Raji"
     gene            1..744
                     /gene="MGMT"
     CDS             16..639
                     /gene="MGMT"
                     /codon_start=1
                     /product="O-6-methylguanine-DNA methyltransferase"
                     /protein_id="AAA59594.1"
                     /db_xref="GDB:G00-125-264"
                     /translation="MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAV
                     EVPAPAAVLGGPEPLMQCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKL
                     LKVVKFGEVISYQQLAALAGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSG
                     GLAVKEWLLAHEGHRLGKPGLGGSSGLAGAWLKGAGATSGSPPAGRN"
     polyA_site      744
                     /gene="MGMT"
                     /note="G00-125-264"
BASE COUNT          162 a          194 c          246 g          142 t
ORIGIN      
        1 ttggtacttg gaaaaatgga caaggattgt gaaatgaaac gcaccacact ggacagccct
       61 ttggggaagc tggagctgtc tggttgtgag cagggtctgc acgaaataaa gctcctgggc
      121 aaggggacgt ctgcagctga tgccgtggag gtcccagccc ccgctgcggt tctcggaggt
      181 ccggagcccc tgatgcagtg cacagcctgg ctgaatgcct atttccacca gcccgaggct
      241 atcgaagagt tccccgtgcc ggcacttcac catcccgttt tccagcaaga gtcgttcacc
      301 agacaggtgt tatggaagct gctgaaggtt gtgaaattcg gagaagtgat ttcttaccag
      361 caattagcag ccctggcagg caaccccaaa gccgcgcgag cagtgggagg agcaatgaga
      421 ggcaatcctg tccccatcct catcccgtgc cacagagtgg tctgcagcag cggagccgtg
      481 ggcaactact ccggaggact ggccgtgaag gaatggcttc tggcccatga aggccaccgg
      541 ttggggaagc caggcttggg agggagctca ggtctggcag gggcctggct caagggagcg
      601 ggagctacct cgggctcccc gcctgctggc cgaaactgag tatgtgcagt aggatggatg
      661 tttgagcgac acacacgtgt aacactgcat cggatgcggg gcgtggaggc accgctgtat
      721 taaaggaagt ggcagtgtcc tggg
//