LOCUS HUMP70S6KB 1791 bp mRNA linear HUM 27-APR-1993
DEFINITION Human p70 ribosomal S6 kinase alpha-II mRNA, complete cds.
ACCESSION M60725
VERSION M60725.1
KEYWORDS p70 ribosomal S6 kinase alpha-II.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1791)
AUTHORS Grove,J.R., Banerjee,P., Balasubramanyam,A., Coffer,P.J.,
Price,D.J., Avruch,J. and Woodgett,J.R.
TITLE Cloning and expression of two human p70 S6 kinase polypeptides
differing only at their amino termini
JOURNAL Mol. Cell. Biol. 11 (11), 5541-5550 (1991)
PUBMED 1922062
COMMENT Original source text: Human liver hepatoma, cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1791
/db_xref="H-InvDB:HIT000195959"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="hepatoma"
/tissue_type="liver"
CDS 99..1607
/codon_start=1
/product="p70 ribosomal S6 kinase alpha-II"
/protein_id="AAA36411.1"
/translation="MAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGME
HCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVL
KKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQ
LEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCK
ESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRK
KTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINW
EELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVA
PSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVE
YPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL"
BASE COUNT 585 a 354 c 438 g 414 t
ORIGIN
1 accatgatac acagcagaag gaggggggaa aaacacgtag atattgccct tcggcttaaa
61 atccagtccc ggacttccga gacagggaag ctgaggacat ggcaggagtg tttgacatag
121 acctggacca gccagaggac gcgggctctg aggatgagct ggaggagggg ggtcagttaa
181 atgaaagcat ggaccatggg ggagttggac catatgaact tggcatggaa cattgtgaga
241 aatttgaaat ctcagaaact agtgtgaaca gagggccaga aaaaatcaga ccagaatgtt
301 ttgagctact tcgggtactt ggtaaagggg gctatggaaa ggtttttcaa gtacgaaaag
361 taacaggagc aaatactggg aaaatatttg ccatgaaggt gcttaaaaag gcaatgatag
421 taagaaatgc taaagataca gctcatacaa aagcagaacg gaatattctg gaggaagtaa
481 agcatccctt catcgtggat ttaatttatg cctttcagac tggtggaaaa ctctacctca
541 tccttgagta tctcagtgga ggagaactat ttatgcagtt agaaagagag ggaatattta
601 tggaagacac tgcctgcttt tacttggcag aaatctccat ggctttgggg catttacatc
661 aaaaggggat catctacaga gacctgaagc cggagaatat catgcttaat caccaaggtc
721 atgtgaaact aacagacttt ggactatgca aagaatctat tcatgatgga acagtcacac
781 acacattttg tggaacaata gaatacatgg cccctgaaat cttgatgaga agtggccaca
841 atcgtgctgt ggattggtgg agtttgggag cattaatgta tgacatgctg actggagcac
901 ccccattcac tggggagaat agaaagaaaa caattgacaa aatcctcaaa tgtaaactca
961 atttgcctcc ctacctcaca caagaagcca gagatctgct taaaaagctg ctgaaaagaa
1021 atgctgcttc tcgtctggga gctggtcctg gggacgctgg agaagttcaa gctcatccat
1081 tctttagaca cattaactgg gaagaacttc tggctcgaaa ggtggagccc ccctttaaac
1141 ctctgttgca atctgaagag gatgtaagtc agtttgattc caagtttaca cgtcagacac
1201 ctgtcgacag cccagatgac tcaactctca gtgaaagtgc caatcaggtc tttctgggtt
1261 ttacatatgt ggctccatct gtacttgaaa gtgtgaaaga aaagttttcc tttgaaccaa
1321 aaatccgatc acctcgaaga tttattggca gcccacgaac acctgtcagc ccagtcaaat
1381 tttctcctgg ggatttctgg ggaagaggtg cttcggccag cacagcaaat cctcagacac
1441 ctgtggaata cccaatggaa acaagtggca tagagcagat ggatgtgaca atgagtgggg
1501 aagcatcggc accacttcca atacgacagc cgaactctgg gccatacaaa aaacaagctt
1561 ttcccatgat ctccaaacgg ccagagcacc tgcgtatgaa tctatgacag agcaatgctt
1621 ttaatgaatt taaggcaaaa aggtggagag ggagatgtgt gagcatcctg caaggtgaaa
1681 caagactcaa aatgacagtt tcagagagtc aatgtcatta catagaacac ttcggacaca
1741 ggaaaaataa acgtggattt taaaaaatca atcaatggtg caaaaaaaaa c
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