LOCUS HUMPGES 2554 bp mRNA linear HUM 17-DEC-1993
DEFINITION Human prostaglandin endoperoxide synthase mRNA, complete cds.
ACCESSION M59979
VERSION M59979.1
KEYWORDS prostaglandin endoperoxide synthase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2554)
AUTHORS Funk,C.D., Funk,L.B., Kennedy,M.E., Pong,A.S. and Fitzgerald,G.A.
TITLE Human platelet/erythroleukemia cell prostaglandin G/H synthase:
cDNA cloning, expression, and gene chromosomal assignment
JOURNAL FASEB J. 5 (9), 2304-2312 (1991)
PUBMED 1907252
REFERENCE 2 (bases 1 to 2554)
AUTHORS Funk,C.D.
TITLE Direct Submission
JOURNAL Submitted (06-MAR-1991) C.D. Funk, Division of Clinical
Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
COMMENT Original source text: Human cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..2554
/db_xref="H-InvDB:HIT000195915"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="blood platelet cell line HEL"
CDS 6..1805
/EC_number="1.14.99.1"
/experiment="experimental evidence, no additional details
recorded"
/codon_start=1
/product="prostaglandin endoperoxide synthase"
/protein_id="AAA03630.1"
/translation="MSRSLLLRFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQG
ICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFV
NATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPT
PMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPG
FTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPR
GIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLI
LIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPD
SFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDV
IRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLL
EKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKL
VCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL"
sig_peptide 6..74
mat_peptide 75..1802
/product="prostaglandin endoperoxide synthase"
/EC_number="1.14.99.1"
BASE COUNT 533 a 697 c 675 g 649 t
ORIGIN
1 gcgccatgag ccggagtctc ttgctccggt tcttgctgtt cctgctcctg ctcccgccgc
61 tccccgtcct gctcgcggac ccaggggcgc ccacgccagt gaatccctgt tgttactatc
121 catgccagca ccagggcatc tgtgtccgct tcggccttga ccgctaccag tgtgactgca
181 cccgcacggg ctattccggc cccaactgca ccatccctgg cctgtggacc tggctccgga
241 attcactgcg gcccagcccc tctttcaccc acttcctgct cactcacggg cgctggttct
301 gggagtttgt caatgccacc ttcatccgag agatgctcat gcgcctggta ctcacagtgc
361 gctccaacct tatccccagt ccccccacct acaactcagc acatgactac atcagctggg
421 agtctttctc caacgtgagc tattacactc gtattctgcc ctctgtgcct aaagattgcc
481 ccacacccat gggaaccaaa gggaagaagc agttgccaga tgcccagctc ctggcccgcc
541 gcttcctgct caggaggaag ttcatacctg acccccaagg caccaacctc atgtttgcct
601 tctttgcaca acacttcacc caccagttct tcaaaacttc tggcaagatg ggtcctggct
661 tcaccaaggc cttgggccat ggggtagacc tcggccacat ttatggagac aatctggagc
721 gtcagtatca actgcggctc tttaaggatg ggaaactcaa gtaccaggtg ctggatggag
781 aaatgtaccc gccctcggta gaagaggcgc ctgtgttgat gcactacccc cgaggcatcc
841 cgccccagag ccagatggct gtgggccagg aggtgtttgg gctgcttcct gggctcatgc
901 tgtatgccac gctctggcta cgtgagcaca accgtgtgtg tgacctgctg aaggctgagc
961 accccacctg gggcgatgag cagcttttcc agacgacccg cctcatcctc ataggggaga
1021 ccatcaagat tgtcatcgag gagtacgtgc agcagctgag tggctatttc ctgcagctga
1081 aatttgaccc agagctgctg ttcggtgtcc agttccaata ccgcaaccgc attgccatgg
1141 agttcaacca tctctaccac tggcaccccc tcatgcctga ctccttcaag gtgggctccc
1201 aggagtacag ctacgagcag ttcttgttca acacctccat gttggtggac tatggggttg
1261 aggccctggt ggatgccttc tctcgccaga ttgctggccg gatcggtggg ggcaggaaca
1321 tggaccacca catcctgcat gtggctgtgg atgtcatcag ggagtctcgg gagatgcggc
1381 tgcagccctt caatgagtac cgcaagaggt ttggcatgaa accctacacc tccttccagg
1441 agctcgtagg agagaaggag atggcagcag agttggagga attgtatgga gacattgatg
1501 cgttggagtt ctaccctgga ctgcttcttg aaaagtgcca tccaaactct atctttgggg
1561 agagtatgat agagattggg gctccctttt ccctcaaggg tctcctaggg aatcccatct
1621 gttctccgga gtactggaag ccgagcacat ttggcggcga ggtgggcttt aacattgtca
1681 agacggccac actgaagaag ctggtctgcc tcaacaccaa gacctgtccc tacgtttcct
1741 tccgtgtgcc ggatgccagt caggatgatg ggcctgctgt ggagcgacca tccacagagc
1801 tctgaggggc aggaaagcag cattctggag gggagagctt tgtgcttgtc attccagagt
1861 gctgaggcca gggctgatgg tcttaaatgc tcattttctg gtttggcatg gtgagtgttg
1921 gggttgacat ttagaacttt aagtctcacc cattatctgg aatattgtga ttctgtttat
1981 tcttccagaa tgctgaactc cttgttagcc cttcagattg ttaggagtgg ttctcatttg
2041 gtctgccaga atactgggtt cttagttgac aacctagaat gtcagatttc tggttgattt
2101 gtaacacagt cattctagga tgtggagcta ctgatgaaat ctgctagaaa gttagggggt
2161 tcttattttg cattccagaa tcttgacttt ctgattggtg attcaaagtg ttgtgttccc
2221 tggctgatga tccagaacag tggctcgtat cccaaatctg tcagcatctg gctgtctaga
2281 atgtggattt gattcatttt cctgttcagt gagatatcat agagacggag atcctaaggt
2341 ccaacaagaa tgcattccct gaatctgtgc ctgcactgag agggcaagga agtggggtgt
2401 tcttcttggg acccccacta agaccctggt ctgaggatgt agagagaaca ggtgggctgt
2461 attcacgcca ttggttggaa gctaccagag ctctatcccc atccaggtct tgactcatgg
2521 cagctgtttc tcatgaagct aataaaattc gccc
//