LOCUS HUMINTA3A 4637 bp mRNA linear HUM 27-APR-1993
DEFINITION Human integrin alpha-3 chain mRNA, complete cds.
ACCESSION M59911
VERSION M59911.1
KEYWORDS collagen receptor; fibronectin; integrin alpha-3 chain; laminin
receptor; transmembrane protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4637)
AUTHORS Takada,Y., Murphy,E., Pil,P., Chen,C., Ginsberg,M.H. and
Hemler,M.E.
TITLE Molecular cloning and expression of the cDNA for alpha 3 subunit of
human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin,
laminin, and collagen
JOURNAL J. Cell Biol. 115 (1), 257-266 (1991)
PUBMED 1655803
COMMENT Original source text: Homo sapiens adult cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..4637
/db_xref="H-InvDB:HIT000195911"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/haplotype="diploid"
/cell_line="HepG2"
/cell_type="endothelial cell"
/dev_stage="adult"
CDS 74..3229
/codon_start=1
/product="integrin alpha-3 chain"
/protein_id="AAA36120.1"
/translation="MGPGPSRAPRAPRLMLCALALMVAAGGCVVSAFNLDTRFLVVKE
AGNPGSLFGYSVALHRQTERQQRYLLLAGAPRELAVPDGYTNRTGAVYLCPLTAHKDD
CERMNITVKNDPGHHIIEDMWLGVTVASQGPAGRVLVCAHRYTQVLWSGSEDQRRMVG
KCYVRGNDLELDSSDDWQTYHNEMCNSNTDYLETGMCQLGTSGGFTQNTVYFGAPGAY
NWKGNSYMIQRKEWDLSEYSYKDPEDQGNLYIGYTMQVGSFILHPKNITIVTGAPRHR
HMGAVFLLSQEAGGDLRRRQVLEGSQVGAYFGSAIALADLNNDGWQDLLVGAPYYFER
KEEVGGAIYVFMNQAGTSFPAHPSLLLHGPSGSAFGLSVASIGDINQDGFQDIAVGAP
FEGLGKVYIYHSSSKGLLRQPQQVIHGEKLGLPGLATFGYSLSGQMDVDENFYPDLLV
GSLSDHIVLLRARPVINIVHKTLVPRPAVLDPALCTATSCVQVELCFAYNQSAGNPNY
RRNITLAYTLEADRDRRPPRLRFAGSESAVFHGFFSMPEMRCQKLELLLMDNLRDKLR
PIIISMNYSLPLRMPDRPRLGLRSLDAYPILNQAQALENHTEVQFQKECGPDNKCESN
LQMRAAFVSEQQQKLSRLQYSRDVRKLLLSINVTNTRTSERSGEDAHEALLTLVVPPA
LLLSSVRPPGACQANETIFCELGNPFKRNQRMELLIAFEVIGVTLHTRDLQVQLQLST
SSHQDNLWPMILTLLVDYTLQTSLSMVNHRLQSFFGGTVMGESGMKTVEDVGSPLKYE
FQVGPMGEGLVGLGTLVLGLEWPYEVSNGKWLLYPTEITVHGNGSWPCRPPGDLINPL
NLTLSDPGDRPSSPQRRRRQLDPGGGQGPPPVTLAAAKKAKSETVLTCATGRAHCVWL
ECPIPDAPVVTNVTVKARVWNSTFIEDYRDFDRVRVNGWATLFLRTSIPTINMENKTT
WFSVDIDSELVEELPAEIELWLVLVAVGAGLLLLGLIILLLWKCGFFKRARTRALYEA
KRQKAEMKSQPSETERLTDDY"
BASE COUNT 962 a 1450 c 1339 g 886 t
ORIGIN chromosome 17.
1 aggtgaacag gtcctcacgc ccagctccgc cccctcacgc gctctcgccg ggaccccgct
61 tccgctggca gccatgggcc ccggccccag ccgcgcgccc cgcgccccac gcctgatgct
121 ctgtgcgctc gccttgatgg tggcggccgg cggctgcgtc gtctccgcct tcaacctgga
181 tacccgattc ctggtagtga aggaggccgg gaacccgggc agcctcttcg gctactcggt
241 cgccctccat cggcagacag agcggcagca gcgctacctg ctcctggctg gtgccccccg
301 ggagctcgct gtgcccgatg gctacaccaa ccggactggt gctgtgtacc tgtgcccact
361 cactgcccac aaggatgact gtgagcggat gaacatcaca gtgaaaaatg accctggcca
421 tcacattatt gaggacatgt ggcttggagt gactgtggcc agccagggcc ctgcaggcag
481 agttctggtc tgtgcccacc gctacaccca ggtgctgtgg tcagggtcag aagaccagcg
541 gcgcatggtg ggcaagtgct acgtgcgagg caatgaccta gagctggact ccagtgatga
601 ctggcagacc taccacaacg agatgtgcaa tagcaacaca gactacctgg agacgggcat
661 gtgccagctg ggcaccagcg gtggcttcac ccagaacact gtgtacttcg gcgcccccgg
721 tgcctacaac tggaaaggaa acagctacat gattcagcgc aaggagtggg acttatctga
781 gtatagttac aaggacccag aggaccaagg aaacctctat attgggtaca cgatgcaggt
841 aggcagcttc atcctgcacc ccaaaaacat caccattgtg acaggtgccc cacggcaccg
901 acatatgggc gcggtgttct tgctgagcca ggaggcaggc ggagacctgc ggaggaggca
961 ggtgctggag ggctcgcagg tgggcgccta ttttggcagc gcaattgccc tggcagacct
1021 gaacaatgat gggtggcagg acctcctggt gggcgccccc tactacttcg agaggaaaga
1081 ggaagtaggg ggtgccatct atgtcttcat gaaccaggcg ggaacctcct tccctgctca
1141 cccctcactc cttcttcatg gccccagtgg ctctgccttt ggtttatctg tggccagcat
1201 tggtgacatc aaccaggatg gatttcagga tattgctgtg ggagctccgt ttgaaggctt
1261 gggcaaagtg tacatctatc acagtagctc taaggggctc cttagacagc cccagcaggt
1321 aatccatgga gagaagctgg gactgcctgg gttggccacc ttcggctatt ccctcagtgg
1381 gcagatggat gtggatgaga acttctaccc agaccttcta gtgggaagcc tgtcagacca
1441 cattgtgctg ctgcgggccc ggccagtcat caacatcgtc cacaagacct tggtgcccag
1501 gccagctgtg ctggaccctg cactttgcac ggccacctct tgtgtgcaag tggagctgtg
1561 ctttgcttac aaccagagtg ccgggaaccc caactacagg cgaaacatca ccctggccta
1621 cactctggag gctgacaggg accgccggcc gccccggctc cgctttgccg gcagtgagtc
1681 cgctgtcttc cacggcttct tctccatgcc cgagatgcgc tgccagaagc tggagctgct
1741 cctgatggac aacctccgtg acaaactccg ccccatcatc atctccatga actactcttt
1801 acctttgcgg atgcccgatc gcccccggct ggggctgcgg tccctggacg cctacccgat
1861 cctcaaccag gcacaggctc tggagaacca cactgaggtc cagttccaga aggagtgcgg
1921 gcctgacaac aagtgtgaga gcaacttgca gatgcgggca gccttcgtgt cagagcagca
1981 gcagaagctg agcaggctcc agtacagcag agacgtccgg aaattgctcc tgagcatcaa
2041 cgtgacgaac acccggacct cggagcgctc cggggaggac gcccacgagg cgctgctcac
2101 cctggtggtg cctcccgccc tgctgctgtc ctcagtgcgc ccccccgggg cctgccaagc
2161 taatgagacc atcttttgcg agctggggaa ccccttcaaa cggaaccaga ggatggagct
2221 gctcatcgcc tttgaggtca tcggggtgac cctgcacaca agggaccttc aggtgcagct
2281 gcagctctcc acgtcgagtc accaggacaa cctgtggccc atgatcctca ctctgctggt
2341 ggactataca ctccagacct cgcttagcat ggtaaatcac cggctacaaa gcttctttgg
2401 ggggacagtg atgggtgagt ctggcatgaa aactgtggag gatgtaggaa gccccctcaa
2461 gtatgaattc caggtgggcc caatggggga ggggctggtg ggcctgggga ccctggtcct
2521 aggtctggag tggccctacg aagtcagcaa tggcaagtgg ctgctgtatc ccacggagat
2581 caccgtccat ggcaatgggt cctggccctg ccgaccacct ggagacctta tcaaccctct
2641 caacctcact ctttctgacc ctggggacag gccatcatcc ccacagcgca ggcgccgaca
2701 gctggatcca gggggaggcc agggcccccc acctgtcact ctggctgctg ccaaaaaagc
2761 caagtctgag actgtgctga cctgtgccac agggcgtgcc cactgtgtgt ggctagagtg
2821 ccccatccct gatgcccccg ttgtcaccaa cgtgactgtg aaggcacgag tgtggaacag
2881 caccttcatc gaggattaca gagactttga ccgagtccgg gtaaatggct gggctaccct
2941 attcctccga accagcatcc ccaccatcaa catggagaac aagaccacgt ggttctctgt
3001 ggacattgac tcggagctgg tggaggagct gccggccgaa atcgagctgt ggctggtgct
3061 ggtggccgtg ggtgcagggc tgctgctgct ggggctgatc atcctcctgc tgtggaagtg
3121 cggcttcttc aagcgagccc gcactcgcgc cctgtatgaa gctaagaggc agaaggcgga
3181 gatgaagagc cagccgtcag agacagagag gctgaccgac gactactgag ggggcagccc
3241 cccgcccccg gcccacctgg tgtgacttct ttaagcggac ccgctattat cagatcatgc
3301 ccaagtacca cgcagtgcgg atccgggagg aggagcgcta cccacctcca gggagcaccc
3361 tgcccaccaa gaagcactgg gtgaccagct ggcagactcg ggaccaatac tactgacgtc
3421 ctccctgatc ccaccccctc ctcccccagt gtcccctttc ttcctattta tcataagtta
3481 tgcctctgac agtccacagg ggccaccacc tttggctggt agcagcaggc tcaggcacat
3541 acacctcgtc aagagcatgc acatgctgtc tggccctggg gatcttccca caggagggcc
3601 agcgctgtgg accttacaac gccgagtgca ctgcattcct gtgccctaga tgcacgtggg
3661 gcccactgct cgtggactgt gctggtgcat cacggatggt gcatgggctc gccgtgtctc
3721 agcctctgcc agcgccagcg ccaaaacaag ccaaagagcc tcccaccaga gccgggagga
3781 aaaggcccct gcaatgtggt gacacctccc ctttcacacc tggatccatc ttgagagcca
3841 cagtcactgg attgactttg ctgtcaaaac tactgacagg gagcagcccc cgggccgctg
3901 gctggtgggc ccccaattga cacccatgcc agagaggtgg ggatcctgcc taaggttgtc
3961 tacgggggca cttggaggac ctggcgtgct cagacccaac agcaaaggaa ctagaaagaa
4021 ggacccagaa ggcttgcttt cctgcatctc tgtgaagcct ctctccttgg ccacagactg
4081 aactcgcagg gagtgcagca ggaaggaaca aagacaggca aacggcaacg tagcctgggc
4141 tcactgtgct ggggcatggc gggatcctcc acagagagga ggggaccaat tctggacaga
4201 cagatgttgg gaggatacag aggagatgcc acttctcact caccactacc agccagcctc
4261 cagaaggccc cagagagacc ctgcaagacc acggagggag ccgacacttg aatgtagtaa
4321 taggcagggg gccctgccac cccatccagc cagaccccag ctgaaccatg cgtcaggggc
4381 ctagaggtgg agttcttagc tatccttggc tttctgtgcc agcctggctc tgcccctccc
4441 ccatgggctg tgtcctaagg cccatttgag aagctgaggc tagttccaaa aacctctcct
4501 gacccctgcc tgttggcagc ccactcccca gccccagccc cttccatggt actgtagcag
4561 gggaattccc tccccctcct tgtgccttct ttgtatatag gcttctcacc gcgaccaata
4621 aacagctccc agtttgt
//