LOCUS HUMECK 3921 bp mRNA linear HUM 21-NOV-1994
DEFINITION Human protein tyrosine kinase mRNA, complete cds.
ACCESSION M59371 M36395
VERSION M59371.1
KEYWORDS protein-tyrosine kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3921)
AUTHORS Lindberg,R.A. and Hunter,T.
TITLE cDNA cloning and characterization of eck, an epithelial cell
receptor protein-tyrosine kinase in the eph/elk family of protein
kinases
JOURNAL Mol. Cell. Biol. 10 (12), 6316-6324 (1990)
PUBMED 2174105
COMMENT Original source text: Human HeLa cell line and keratinocyte, cDNA
to mRNA.
FEATURES Location/Qualifiers
source 1..3921
/db_xref="H-InvDB:HIT000195893"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="Unassigned"
/cell_line="HeLa and keratinocyte"
gene 1..3921
/gene="ECK"
mRNA 1..3921
/gene="ECK"
/product="protein-tyrosine kinase"
/note="G00-126-726"
CDS 114..3044
/gene="ECK"
/codon_start=1
/product="protein-tyrosine kinase"
/protein_id="AAA53375.1"
/db_xref="GDB:G00-126-726"
/translation="MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWL
THPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERNNFELNFTV
RDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARH
VKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGS
DAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQAC
SPGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPPSAPHY
LTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCEASVRYSEPPHGL
TRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTT
SLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQ
ALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRRKNQR
ARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEF
GEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVI
SKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDL
AARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSAS
DVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQ
ERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLE
SIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLKDQVNTV
GIPI"
BASE COUNT 782 a 1180 c 1183 g 776 t
ORIGIN
1 cggaagttgc gcgcaggccg gcgggcggga gcggacaccg aggccggcgt gcaggcgtgc
61 gggtgtgcgg gagccgggct cggggggatc ggaccgagag cgagaagcgc ggcatggagc
121 tccaggcagc ccgcgcctgc ttcgccctgc tgtggggctg tgcgctggcc gcggccgcgg
181 cggcgcaggg caaggaagtg gtactgctgg actttgctgc agctggaggg gagctcggct
241 ggctcacaca cccgtatggc aaagggtggg acctgatgca gaacatcatg aatgacatgc
301 cgatctacat gtactccgtg tgcaacgtga tgtctggcga ccaggacaac tggctccgca
361 ccaactgggt gtaccgagga gaggctgagc gtaacaactt tgagctcaac tttactgtac
421 gtgactgcaa cagcttccct ggtggcgcca gctcctgcaa ggagactttc aacctctact
481 atgccgagtc ggacctggac tacggcacca acttccagaa gcgcctgttc accaagattg
541 acaccattgc gcccgatgag atcaccgtca gcagcgactt cgaggcacgc cacgtgaagc
601 tgaacgtgga ggagcgctcc gtggggccgc tcacccgcaa aggcttctac ctggccttcc
661 aggatatcgg tgcctgtgtg gcgctgctct ccgtccgtgt ctactacaag aagtgccccg
721 agctgctgca gggcctggcc cacttccctg agaccatcgc cggctctgat gcaccttccc
781 tggccactgt ggccggcacc tgtgtggacc atgccgtggt gccaccgggg ggtgaagagc
841 cccgtatgca ctgtgcagtg gatggcgagt ggctggtgcc cattgggcag tgcctgtgcc
901 aggcaggcta cgagaaggtg gaggatgcct gccaggcctg ctcgcctgga ttttttaagt
961 ttgaggcatc tgagagcccc tgcttggagt gccctgagca cacgctgcca tcccctgagg
1021 gtgccacctc ctgcgagtgt gaggaaggct tcttccgggc acctcaggac ccagcgtcga
1081 tgccttgcac acgaccccct tccgccccac actacctcac agccgtgggc atgggtgcca
1141 aggtggagct gcgctggacg ccccctcagg acagcggggg ccgcgaggac attgtctaca
1201 gcgtcacctg cgaacagtgc tggcccgagt ctggggaatg cgggccgtgt gaggccagtg
1261 tgcgctactc ggagcctcct cacggactga cccgcaccag tgtgacagtg agcgacctgg
1321 agccccacat gaactacacc ttcaccgtgg aggcccgcaa tggcgtctca ggcctggtaa
1381 ccagccgcag cttccgtact gccagtgtca gcatcaacca gacagagccc cccaaggtga
1441 ggctggaggg ccgcagcacc acctcgctta gcgtctcctg gagcatcccc ccgccgcagc
1501 agagccgagt gtggaagtac gaggtcactt accgcaagaa gggagactcc aacagctaca
1561 atgtgcgccg caccgagggt ttctccgtga ccctggacga cctggcccca gacaccacct
1621 acctggtcca ggtgcaggca ctgacgcagg agggccaggg ggccggcagc aaggtgcacg
1681 aattccagac gctgtccccg gagggatctg gcaacttggc ggtgattggc ggcgtggctg
1741 tcggtgtggt cctgcttctg gtgctggcag gagttggctt ctttatccac cgcaggagga
1801 agaaccagcg tgcccgccag tccccggagg acgtttactt ctccaagtca gaacaactga
1861 agcccctgaa gacatacgtg gacccccaca catatgagga ccccaaccag gctgtgttga
1921 agttcactac cgagatccat ccatcctgtg tcactcggca gaaggtgatc ggagcaggag
1981 agtttgggga ggtgtacaag ggcatgctga agacatcctc ggggaagaag gaggtgccgg
2041 tggccatcaa gacgctgaaa gccggctaca cagagaagca gcgagtggac ttcctcggcg
2101 aggccggcat catgggccag ttcagccacc acaacatcat ccgcctagag ggcgtcatct
2161 ccaaatacaa gcccatgatg atcatcactg agtacatgga gaatggggcc ctggacaagt
2221 tccttcggga gaaggatggc gagttcagcg tgctgcagct ggtgggcatg ctgcggggca
2281 tcgcagctgg catgaagtac ctggccaaca tgaactatgt gcaccgtgac ctggctgccc
2341 gcaacatcct cgtcaacagc aacctggtct gcaaggtgtc tgactttggc ctgtcccgcg
2401 tgctggagga cgaccccgag gccacctaca ccaccagtgg cggcaagatc cccatccgct
2461 ggaccgcccc ggaggccatt tcctaccgga agttcacctc tgccagcgac gtgtggagct
2521 ttggcattgt catgtgggag gtgatgacct atggcgagcg gccctactgg gagttgtcca
2581 accacgaggt gatgaaagcc atcaatgatg gcttccggct ccccacaccc atggactgcc
2641 cctccgccat ctaccagctc atgatgcagt gctggcagca ggagcgtgcc cgccgcccca
2701 agttcgctga catcgtcagc atcctggaca agctcattcg tgcccctgac tccctcaaga
2761 ccctggctga ctttgacccc cgcgtgtcta tccggctccc cagcacgagc ggctcggagg
2821 gggtgccctt ccgcacggtg tccgagtggc tggagtccat caagatgcag cagtatacgg
2881 agcacttcat ggcggccggc tacactgcca tcgagaaggt ggtgcagatg accaacgacg
2941 acatcaagag gattggggtg cggctgcccg gccaccagaa gcgcatcgcc tacagcctgc
3001 tgggactcaa ggaccaggtg aacactgtgg ggatccccat ctgagcctcg acagggcctg
3061 gagccccatc ggccaagaat acttgaagaa acagagtggc ctccctgctg tgccatgctg
3121 ggccactggg gactttattt atttctagtt ctttcctccc cctgcaactt ccgctgaggg
3181 gtctcggatg acaccctggc ctgaactgag gagatgacca gggatgctgg gctgggccct
3241 ctttccctgc gagacgcaca cagctgagca cttagcaggc accgccacgt cccagcatcc
3301 ctggagcagg agccccgcca cagccttcgg acagacatat aggatattcc caagccgacc
3361 ttccctccgc cttctcccac atgaggccat ctcaggagat ggagggcttg gcccagcgcc
3421 aagtaaacag ggtacctcaa gccccatttc ctcacactaa gagggcagac tgtgaacttg
3481 actgggtgag acccaaagcg gtccctgtcc ctctagtgcc ttctttagac cctcgggccc
3541 catcctcatc cctgactggc caaacccttg ctttcctggg cctttgcaag atgcttggtt
3601 gtgttgaggt ttttaaatat atattttgta ctttgtggag agaatgtgtg tgtgtggcag
3661 ggggccccgc cagggctggg gacagagggt gtcaaacatt cgtgagctgg ggactcaggg
3721 accggtgctg caggagtgtc ctgcccatgc cccagtcggc cccatctctc atccttttgg
3781 ataagtttct attctgtcag tgttaaagat tttgttttgt tggacatttt tttcgaatct
3841 taatttatta ttttttttat atttattgtt agaaaatgac ttatttctgc tctggaataa
3901 agttgcagat gattcaaacc g
//