LOCUS HUMFBRABI 4330 bp RNA linear HUM 18-DEC-1998
DEFINITION Homo sapiens fibrinogen alpha subunit and fibrinogen alpha subunit
precursor, genes, complete cds.
ACCESSION M58569
VERSION M58569.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2181)
AUTHORS Rixon,M.W., Chan,W.Y., Davie,E.W. and Chung,D.W.
TITLE Characterization of a complementary deoxyribonucleic acid coding
for the alpha chain of human fibrinogen
JOURNAL Biochemistry 22 (13), 3237-3244 (1983)
PUBMED 6688355
REFERENCE 2 (bases 1 to 2698)
AUTHORS Chung,D.W., Harris,J.E. and Davie,E.W.
TITLE Nucleotide sequences of the three genes coding for human fibrinogen
JOURNAL Adv. Exp. Med. Biol. 281, 39-48 (1990)
PUBMED 2102623
REFERENCE 3 (sites)
AUTHORS Weissbach,L. and Grieninger,G.
TITLE Bipartite mRNA for chicken alpha-fibrinogen potentially encodes an
amino acid sequence homologous to beta- and gamma-fibrinogens
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (13), 5198-5202 (1990)
PUBMED 2367530
REFERENCE 4 (bases 1 to 4330)
AUTHORS Fu,Y., Weissbach,L., Plant,P.W., Oddoux,C., Cao,Y., Liang,T.J.,
Roy,S.N., Redman,C.M. and Grieninger,G.
TITLE Carboxy-terminal-extended variant of the human fibrinogen alpha
subunit: a novel exon conferring marked homology to beta and gamma
subunits
JOURNAL Biochemistry 31 (48), 11968-11972 (1992)
PUBMED 1457396
COMMENT Complete gene is in M64982.
FEATURES Location/Qualifiers
source 1..4330
/db_xref="H-InvDB:HIT000365135"
/organism="Homo sapiens"
/mol_type="transcribed RNA"
/db_xref="taxon:9606"
/tissue_type="liver"
misc_RNA 1..4330
/note="bipartite transcript, apparent human counterpart to
bipartite chicken mRNA for fibrinogen alpha subunit (for
chicken transcript, see citation [2])"
/citation=[4]
CDS join(30..1920,2625..3334)
/note="extended alpha-E variant"
/citation=[4]
/codon_start=1
/product="fibrinogen alpha subunit precursor"
/protein_id="AAC97142.1"
/translation="MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQ
SACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDS
HSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVR
AQLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDR
QHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTS
YGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSW
NSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGS
FRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEKVT
SGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDG
FRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPG
IAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHA
KSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGS
LNFNRTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEY
HFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRDADQWEEN
CAEVYGGGWWYNNCQAANLNGIYYPGGSYDPRNNSPYEIENGVVWVSFRGADYSLRAV
RMKIRPLVTQ"
sig_peptide 30..86
mat_peptide join(87..1920,2625..3331)
/product="fibrinogen alpha subunit"
/note="extended variant alpha-E"
CDS 30..1964
/codon_start=1
/product="fibrinogen alpha subunit"
/protein_id="AAC97143.1"
/translation="MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQ
SACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDS
HSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVR
AQLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDR
QHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTS
YGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSW
NSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGS
FRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEKVT
SGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDG
FRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPG
IAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHA
KSRPVRGIHTSPLGKPSLSP"
mat_peptide 87..1961
/product="fibrinogen alpha subunit"
/note="predominant form; lacks C-terminal homology with
beta and gamma subunits"
intron 1921..2624
/note="this RNA sequence is spliced out to form the mRNA
for the extended alpha subunit (alpha-E)"
/citation=[4]
/number=5
misc_RNA 1921..1964
/note="alternatively used as 5'-end of intron which is
spliced out to form alpha-E mRNA or as 3' end of exon 5
where it contributes the last 14 codons for predominant
alpha subunit mRNA"
/citation=[1]
/citation=[2]
/citation=[4]
polyA_site 2181..2182
/note="for predominant alpha subunit mRNA"
/citation=[1]
polyA_site 3534..3535
/note="for extended variant alpha-E; alternate"
/citation=[4]
polyA_site 4064..4065
/note="for extended variant alpha-E; alternate"
/citation=[4]
polyA_site 4330
/note="for extended variant alpha-E; alternate"
/citation=[4]
BASE COUNT 1295 a 869 c 965 g 1201 t
ORIGIN
1 tctaggagcc agccccaccc ttagaaaaga tgttttccat gaggatcgtc tgcctggtcc
61 taagtgtggt gggcacagca tggactgcag atagtggtga aggtgacttt ctagctgaag
121 gaggaggcgt gcgtggccca agggttgtgg aaagacatca atctgcctgc aaagattcag
181 actggccctt ctgctctgat gaagactgga actacaaatg cccttctggc tgcaggatga
241 aagggttgat tgatgaagtc aatcaagatt ttacaaacag aataaataag ctcaaaaatt
301 cactatttga atatcagaag aacaataagg attctcattc gttgaccact aatataatgg
361 aaattttgag aggcgatttt tcctcagcca ataaccgtga taatacctac aaccgagtgt
421 cagaggatct gagaagcaga attgaagtcc tgaagcgcaa agtcatagaa aaagtacagc
481 atatccagct tctgcagaaa aatgttagag ctcagttggt tgatatgaaa cgactggagg
541 tggacattga tattaagatc cgatcttgtc gagggtcatg cagtagggct ttagctcgtg
601 aagtagatct gaaggactat gaagatcagc agaagcaact tgaacaggtc attgccaaag
661 acttacttcc ctctagagat aggcaacact taccactgat aaaaatgaaa ccagttccag
721 acttggttcc cggaaatttt aagagccagc ttcagaaggt acccccagag tggaaggcat
781 taacagacat gccgcagatg agaatggagt tagagagacc tggtggaaat gagattactc
841 gaggaggctc cacctcttat ggaaccggat cagagacgga aagccccagg aaccctagca
901 gtgctggaag ctggaactct gggagctctg gacctggaag tactggaaac cgaaaccctg
961 ggagctctgg gactggaggg actgcaacct ggaaacctgg gagctctgga cctggaagta
1021 ctggaagctg gaactctggg agctctggaa ctggaagtac tggaaaccaa aaccctggga
1081 gccctagacc tggtagtacc ggaacctgga atcctggcag ctctgaacgc ggaagtgctg
1141 ggcactggac ctctgagagc tctgtatctg gtagtactgg acaatggcac tctgaatctg
1201 gaagttttag gccagatagc ccaggctctg ggaacgcgag gcctaacaac ccagactggg
1261 gcacatttga agaggtgtca ggaaatgtaa gtccagggac aaggagagag taccacacag
1321 aaaaactggt cacttctaaa ggagataaag agctcaggac tggtaaagag aaggtcacct
1381 ctggtagcac aaccaccacg cgtcgttcat gctctaaaac cgttactaag actgttattg
1441 gtcctgatgg tcacaaagaa gttaccaaag aagtggtgac ctccgaagat ggttctgact
1501 gtcccgaggc aatggattta ggcacattgt ctggcatagg tactctggat gggttccgcc
1561 ataggcaccc tgatgaagct gccttcttcg acactgcctc aactggaaaa acattcccag
1621 gtttcttctc acctatgtta ggagagtttg tcagtgagac tgagtctagg ggctcagaat
1681 ctggcatctt cacaaataca aaggaatcca gttctcatca ccctgggata gctgaattcc
1741 cttcccgtgg taaatcttca agttacagca aacaatttac tagtagcacg agttacaaca
1801 gaggagactc cacatttgaa agcaagagct ataaaatggc agatgaggcc ggaagtgaag
1861 ccgatcatga aggaacacat agcaccaaga gaggccatgc taaatctcgc cctgtcagag
1921 gtatccacac ttctcctttg gggaagcctt ccctgtcccc ctagactaag ttaaatattt
1981 ctgcacagtg ttcccatggc cccttgcatt tccttcttaa ctctctgtta cacgtcattg
2041 aaactacact tttttggtct gtttttgtgc tagactgtaa gttccttggg ggcagggcct
2101 ttgtctgtct catctctgta ttcccaaatg cctaacagta cagagccatg actcaataaa
2161 tacatgttaa atggatgaat gaattcctct gaaactctat ttgagcttat ttagtcaaat
2221 tctttcacta ttcaaagtgt gtgctattag aattgtcacc caactgatta atcacatttt
2281 tagtatgtgt ctcagttgac atttaggtca ggctaaatac aagttgtgtt agtattaagt
2341 gatgcttagc tacctgtact ggttacttgc tattagtttg tgcaagtaaa attccaaata
2401 catttgagga aaatcccctt tgcaatttgt aggtataaat aaccgcttat ttgcataagt
2461 tctatcccac tgtaagtgca tcctttccct atggagggaa ggaaaggagg aagaaagaaa
2521 ggaagggaaa gaaacagtat ttgccttatt taatctgagc cgtgcctatc tttgtaaagt
2581 taaatgagaa taacttcttc caaccagctt aatttttttt ttagactgtg atgatgtcct
2641 ccaaacacat ccttcaggta cccaaagtgg cattttcaat atcaagctac cgggatccag
2701 taagattttt tctgtttatt gcgatcaaga gaccagtttg ggaggatggc ttttgatcca
2761 gcaaagaatg gatggatcac tgaattttaa ccggacctgg caagactaca agagaggttt
2821 cggcagcctg aatgacgagg gggaaggaga attctggcta ggcaatgact acctccactt
2881 actaacccaa aggggctctg ttcttagggt tgaattagag gactgggctg ggaatgaagc
2941 ttatgcagaa tatcacttcc gggtaggctc tgaggctgaa ggctatgccc tccaagtctc
3001 ctcctatgaa ggcactgcgg gtgatgctct gattgagggt tccgtagagg aaggggcaga
3061 gtacacctct cacaacaaca tgcagttcag cacctttgac agggatgcag accagtggga
3121 agagaactgt gcagaagtct atgggggagg ctggtggtat aataactgcc aagcagccaa
3181 tctcaatgga atctactacc ctgggggctc ctatgaccca aggaataaca gtccttatga
3241 gattgagaat ggagtggtct gggtttcctt tagaggggca gattattccc tcagggctgt
3301 tcgcatgaaa attaggcccc ttgtgaccca ataggctgaa gaagtgggaa tgggagcact
3361 ctgtcttctt tgctagagaa gtggagagaa aatacaaaag gtaaagcagt tgagattctc
3421 tacaacctaa aaaattccta ggtgctattt tcttatcctt tgtactgtag ctaaatgtac
3481 ctgagacata ttagtctttg aaaaataaag ttatgtaagg ttttttttat ctttaaatag
3541 ctctgtgggt tttaacattt ttgtaaagat ataccaaggg ccattcagta catcaggaaa
3601 gtggcagaca gaagcttctc tctgcaacct tgaagactat tggtttgaga acttctcttc
3661 ccataccacc caaaatcata atgccattgg aaagcaaaaa gttgttttat ccatttgatt
3721 tgaattgttt taagccaata ttttaaggta aaactcactg aatctaacca tagctgacct
3781 ttgtagtaga atttacaact tataattaca atgcacaatt tataattaca atatgtattt
3841 atgtcttttg ctatggagca aatccaggaa ggcaagagaa acattctttc ctaaatataa
3901 atgaaaatct atcctttaaa ctcttccact agacgttgta atgcacactt atttttttcc
3961 caaggagtaa ccaatttctt tctaaaacac atttaaaatt ttaaaactat ttatgaatat
4021 taaaaaaaga cataattcac acattaataa acaatctccc aagtattgat ttaacttcat
4081 ttttctaata atcataaact atattctgtg acatgctaat tattattaaa tgtaagtcgt
4141 tagttcgaaa gcctctcact aagtatgatc tatgctatat tcaaaattca acccatttac
4201 tttggtcaat atttgatcta agttgcatct ttaatcctgg tggtcttgcc ttctgatttt
4261 taatttgtat ccttttctat taagatatat ttgtcatttt ctcttgaata tgtattaaaa
4321 tatcccaagc
//