LOCUS HUMIREBPA 2889 bp mRNA linear HUM 14-JUL-1995
DEFINITION Human iron-responsive element-binding protein/iron regulatory
protein 2 (IRE-BP2/IRP2) mRNA, partial cds.
ACCESSION M58511 M37836
VERSION M58511.1
KEYWORDS RNA regulatory protein; iron-responsive element-binding protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2889)
AUTHORS Rouault,T.A., Tang,C.K., Kaptain,S., Burgess,W.H., Haile,D.J.,
Samaniego,F., McBride,O.W., Harford,J.B. and Klausner,R.D.
TITLE Cloning of the cDNA encoding an RNA regulatory protein--the human
iron-responsive element-binding protein
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (20), 7958-7962 (1990)
PUBMED 2172968
REFERENCE 2 (bases 1 to 2889)
AUTHORS Samaniego,F., Chin,J., Iwai,K., Rouault,T.A. and Klausner,R.D.
TITLE Molecular characterization of a second iron-responsive element
binding protein, iron regulatory protein 2. Structure, function,
and post-translational regulation
JOURNAL J. Biol. Chem. 269 (49), 30904-30910 (1994)
PUBMED 7983023
REFERENCE 3 (bases 1 to 2889)
AUTHORS Rouault,T.A., Haile,D.J., Downey,W.E., Philpott,C.C., Tang,C.,
Samaniego,F., Chin,J., Paul,I., Orloff,D., Harford,J.B. et al.
TITLE An iron-sulfur cluster plays a novel regulatory role in the
iron-responsive element binding protein
JOURNAL Biometals 5 (3), 131-140 (1992)
PUBMED 1421965
REFERENCE 4 (bases 1 to 2889)
AUTHORS Rouault,T.A.
TITLE Direct Submission
JOURNAL Submitted (17-DEC-1990) Tracey A. Rouault, Cell Biology and
Metabolism Branch, NICHHD, NIH, Bethesda, MD 20992, USA
COMMENT On Jul 14, 1995 this sequence version replaced gi:186547.
Original source text: Human cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..2889
/db_xref="H-InvDB:HIT000195872"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="9p"
/cell_line="YT"
/cell_type="T cell"
/dev_stage="adult"
gene 1..2889
/gene="IRE-BP2/IRP2"
CDS 1..>2889
/gene="IRE-BP2/IRP2"
/codon_start=1
/product="iron-responsive element-binding protein/iron
regulatory protein 2"
/protein_id="AAA69901.1"
/translation="MDAPKAGYAFEYLIETLNDSSHKKFFDVSKLGTKYDVLPYSIRV
LLEAAVRNCDGFLMKKEDVMNILDWKTKQSNVEVPFFPARVLLQDFTGIPAMVDFAAM
REAVKTLGGDPEKVHPACPTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLK
VQPKKLPCRGQTTCRGSCDSGELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQ
EVEFGRNRERLQFFKWSSRVLKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSV
VGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSID
VVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTL
KHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKR
PQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYEGSEYKLSHGSVVIAA
VISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYL
SKLGFEIVGYGCSTCVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNFEGRLCDCVRAN
YLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGKNIYLHDIWPSREEVHRVEEEHVILS
MFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRCPSFFDKLTKEPIALQAIENA
HVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGT
FANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRD
WAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRETFSLTF
PEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNFVARKFS"
BASE COUNT 879 a 534 c 637 g 839 t
ORIGIN
1 atggacgccc caaaagcagg atacgccttt gagtacctta ttgaaacatt aaatgacagt
61 tcacataaga agttcttcga tgtatctaaa cttggcacca agtatgatgt tctgccttac
121 tcaatacggg tcttgttgga agctgctgta cgaaattgtg atggcttttt aatgaagaag
181 gaagatgtta tgaacatttt agactggaaa accaaacaaa gcaatgttga agtgcccttt
241 ttccctgccc gtgttcttct tcaagatttt actggaatac cagcaatggt ggattttgct
301 gctatgaggg aggcagtgaa aactcttgga ggtgatcctg agaaagtcca tcctgcttgt
361 ccgacagatc ttacagttga ccattcttta caaattgact tcagtaaatg tgcaatacag
421 aatgcaccaa atcctggagg tggtgacctg cagaaagcag gaaagctctc tccacttaaa
481 gtgcagccta agaagcttcc ctgcagaggc cagactacct gccgaggatc ttgtgattct
541 ggagaactag gccgaaactc aggaacattt tcttcgcaga ttgagaatac acccatcctg
601 tgtccttttc atttgcaacc agtgcctgaa cctgaaacag tgttaaaaaa tcaagaagta
661 gaattcggca gaaatcgaga gaggcttcag ttttttaagt ggagttcaag agttttaaag
721 aatgtggcag tgatccctcc tggaactgga atggctcatc aaataaactt agaatatttg
781 tcaagagtgg tttttgaaga aaaagacctc ctcttcccag acagtgtagt cggcacagat
841 tcacacataa cgatggtgaa tggtttaggg attctggggt ggggggttgg aggcattgaa
901 acagaagcag ttatgcttgg tctgccagtt tctcttactt taccagaggt ggttggatgt
961 gagttaactg ggtcatcaaa cccttttgtt acatccatag atgttgttct tggtattaca
1021 aagcacctca ggcaagtagg agtggctgga aagtttgttg agttttttgg aagtggagtt
1081 tcacaattat ctatagttga tcgaactaca atagcaaaca tgtgtccgga atatggtgct
1141 atcctcagct ttttccctgt tgacaatgtg acattaaaac atttagaaca tacaggtttt
1201 agcaaagcca aactcgaatc aatggaaaca taccttaaag ctgtgaaatt gtttcgaaat
1261 gaccagaatt cttcaggaga acctgaatac tcccaggtga tccagattaa tctgaattca
1321 atagttccat ctgttagtgg tccaaaaaga cctcaggata gagttgctgt gacagatatg
1381 aaaagcgatt tccaggcttg cttaaatgaa aaggttggat ttaaaggctt ccaaattgca
1441 gctgaaaaac aaaaggatat tgtctccatt cattatgaag gaagtgaata taagctgtct
1501 catggatcag tggtcattgc tgcagttatc agttgtacca ataattgcaa tccatctgtc
1561 atgcttgctg caggtctttt ggctaaaaag gctgttgaag ctggtctgcg tgttaaacct
1621 tatataagaa caagtttatc tccaggcagt gggatggtta cacattacct cagttcaagt
1681 ggagtattac catatctaag taagcttgga tttgaaatcg ttggctatgg atgttcaact
1741 tgtgtgggaa atacagcacc cttatcagac gcagttttaa atgcagtaaa acagggtgat
1801 ttggttacct gtggaatttt atctggaaac aaaaattttg aaggtcgtct ttgtgattgt
1861 gttcgtgcca attatcttgc ctctccaccc ttagtggtag cttatgccat agcaggcaca
1921 gtgaatatag atttccagac agaaccttta ggtactgacc ccaccggcaa gaacatttac
1981 ctgcatgata tttggcctag tcgagaagaa gttcatcgag tagaggaaga acatgttata
2041 ctatccatgt ttaaagcatt aaaagataaa atagaaatgg ggaataaacg gtggaattcc
2101 ttagaagcac cggattcagt tttgtttcca tgggacttaa agtctactta tatcagatgc
2161 ccttcatttt ttgataaact taccaaagag ccaattgcac tccaggctat tgaaaatgcc
2221 catgtcttat tatatttggg agactctgtc acaacagatc atatatcacc tgcaggaagt
2281 atcgctagga atagtgctgc cgctaagtat ttgacaaaca gaggccttac ccctcgtgaa
2341 ttcaactctt acggagctcg aagaggtaat gatgctgtaa tgacaagagg cacttttgca
2401 aatatcaagc tttttaataa gtttattgga aaaccagctc ctaaaacaat tcattttcca
2461 tcaggacaga cgctagatgt atttgaggct gcagagctgt accagaaaga aggtatccca
2521 ctgattattt tagcaggaaa gaaatatggt tcaggaaact ccagagactg ggctgccaaa
2581 ggaccgtatt tactgggtgt gaaagctgtt ttggctgaaa gttatgaaaa aatacacaaa
2641 gatcatttga ttggaattgg catagctcca cttcagttcc ttccaggaga aaatgcagat
2701 tccttgggcc tctccggtag agaaacattt tctttaacat ttcctgaaga actgtctcct
2761 ggaattacat tgaatataca gacaagcact ggaaaagtat tcagcgtgat tgcttcgttt
2821 gaagatgatg tggaaataac attatacaaa catggaggat tattaaactt tgtggcacga
2881 aaattctca
//