LOCUS HUMIREBP 3174 bp mRNA linear HUM 14-JUL-1995
DEFINITION Human iron-responsive element-binding protein/iron regulatory
protein 1 (IRE-BP1/IRP1) mRNA, partial cds.
ACCESSION M58510 M37835
VERSION M58510.1
KEYWORDS RNA regulatory protein; iron-responsive element-binding protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3174)
AUTHORS Rouault,T.A., Tang,C.K., Kaptain,S., Burgess,W.H., Haile,D.J.,
Samaniego,F., McBride,O.W., Harford,J.B. and Klausner,R.D.
TITLE Cloning of the cDNA encoding an RNA regulatory protein--the human
iron-responsive element-binding protein
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (20), 7958-7962 (1990)
PUBMED 2172968
REFERENCE 2 (bases 1 to 3174)
AUTHORS Rouault,T.A.
TITLE Direct Submission
JOURNAL Submitted (17-DEC-1990) Tracey A. Rouault, Cell Biology and
Metabolism Branch, NICHHD, NIH, Bethesda, MD 20992, USA
COMMENT On Jul 13, 1995 this sequence version replaced gi:186545.
Original source text: Human cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..3174
/db_xref="H-InvDB:HIT000195871"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="9p"
/cell_line="YT"
/cell_type="T cell"
gene 1..3174
/gene="IRE-BP/IRP1"
mRNA <1..3174
/gene="IRE-BP/IRP1"
/product="iron-responsive regulatory protein/iron
regulatory protein 1"
gene 1..2453
/gene="IRE-BP1/IRP1"
CDS <1..2453
/gene="IRE-BP1/IRP1"
/codon_start=3
/product="iron-responsive regulatory protein/iron
regulatory protein 1"
/protein_id="AAA69900.1"
/translation="IEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPV
CPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSG
IIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQ
PISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIA
DRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDP
SQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPE
HHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMP
YIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQ
GDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKG
QQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSK
STYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLT
NRGLTPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDA
AERYQQAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGV
IPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVEL
TYFLNGGILNYMIRKMAK"
BASE COUNT 832 a 725 c 770 g 847 t
ORIGIN
1 acatagaagt gccatttaag cctgctcgtg tcatcctgca ggactttacg ggtgtgcccg
61 ctgtggttga ctttgctgca atgcgtgatg ctgtgaaaaa gttaggagga gatccagaga
121 aaataaaccc tgtctgccct gctgatcttg taatagatca ttccatccag gttgatttca
181 acagaagggc agacagctta cagaagaatc aagacctgga atttgaaaga aatagagagc
241 gatttgaatt tttaaagtgg ggttcccagg cttttcacaa catgcggatt attccccctg
301 gctcaggaat catccaccag gtgaatttgg aatatttggc aagagtggta tttgatcagg
361 atggatatta ttacccagac agcctcgtgg gcacagactc gcacactacc atgattgatg
421 gcttgggcat tcttggttgg ggtgtcggtg gtattgaagc agaagctgtc atgctgggtc
481 agccaatcag tatggtgctt cctcaggtga ttggctacag gctgatgggg aagccccacc
541 ctctggtaac atccactgac atcgtgctca ccattaccaa gcacctccgc caggttgggg
601 tagtgggcaa atttgtcgag ttcttcgggc ctggagtagc ccagttgtcc attgctgacc
661 gagctacgat tgctaacatg tgtccagagt acggagcaac tgctgccttt ttcccagttg
721 atgaagttag tatcacgtac ctggtgcaaa caggtcgtga tgaagaaaaa ttaaagtata
781 ttaaaaaata tcttcaggct gtaggaatgt ttcgagattt caatgaccct tctcaagacc
841 cagacttcac ccaggttgtg gaattagatt tgaaaacagt agtgccttgc tgtagtggac
901 ccaaaaggcc tcaggacaaa gttgctgtgt ccgacatgaa aaaggacttt gagagctgcc
961 ttggagccaa gcaaggattt aaaggattcc aagttgctcc tgaacatcat aatgaccata
1021 agacctttat ctatgataac actgaattca cccttgctca tggttctgtg gtcattgctg
1081 ccattactag ctgcacaaac accagtaatc cgtctgtgat gttaggggca ggattgttag
1141 caaagaaagc tgtggatgct ggcctgaacg tgatgcctta catcaaaact agcctgtctc
1201 ctgggagtgg cgtggtcacc tactacctac aagaaagcgg agtcatgcct tatctgtctc
1261 agcttgggtt tgacgtggtg ggctatggct gcatgacctg cattggcaac agtgggcctt
1321 tacctgaacc tgtggtagaa gccatcacac agggagacct tgtagctgtt ggagtactat
1381 ctggaaacag gaattttgaa ggtcgagttc accccaacac ccgggccaac tatttagcct
1441 ctcccccctt agtaatagca tatgcaattg ctggaaccat cagaatcgac tttgagaaag
1501 agccattggg agtaaatgca aagggacagc aggtatttct gaaagatatc tggccgacta
1561 gagacgagat ccaggcagtg gagcgtcagt atgtcatccc ggggatgttt aaggaagtct
1621 atcagaaaat agagactgtg aatgaaagct ggaatgcctt agcaacccca tcagataagc
1681 tgtttttctg gaattccaaa tctacgtata tcaaatcacc accattcttt gaaaacctga
1741 ctttggatct tcagccccct aaatctatag tggatgccta tgtgctgcta aatttgggag
1801 attcggtaac aactgaccac atctccccag ctggaaatat tgcaagaaac agtcctgctg
1861 ctcgctactt aactaacaga ggcctaactc cacgagaatt caactcctat ggctcccgcc
1921 gaggtaatga cgccgtcatg gcacggggaa catttgccaa cattcgcttg ttaaacagat
1981 ttttgaacaa gcaggcacca cagactatcc atctgccttc tggggaaatc cttgatgtgt
2041 ttgatgctgc tgagcggtac cagcaggcag gccttcccct gatcgttctg gctggcaaag
2101 agtacggtgc aggcagctcc cgagactggg cagctaaggg ccctttcctg ctgggaatca
2161 aagccgtcct ggccgagagc tacgagcgca ttcaccgcag taacctggtt gggatgggtg
2221 tgatcccact tgaatatctc cctggtgaga atgcagatgc cctggggctc acagggcaag
2281 aacgatacac tatcattatt ccagaaaacc tcaaaccaca aatgaaagtc caggtcaagc
2341 tggatactgg caagaccttc caggctgtca tgaggtttga cactgatgtg gagctcactt
2401 atttcctcaa cgggggcatc ctcaactaca tgatccgcaa gatggccaag taggagacgt
2461 gcacttggtc gtgcgcccag ggaggaagcc gcaccaccag ccagcgcagg ccctggtgga
2521 gaggcctccc tggctgcctc tgggaggggt gctgccttgt agatggagca agtgagcact
2581 gagggtctgg tgccaatcct gtaggcacaa aaccagaagg ttctacattc tctatttttg
2641 ttaatcatct tctctttttc cagaatttgg aagctagaat ggtgggaatg tcagtagtgc
2701 cagaaagaga gaaccaagct tgtctttaaa gttactgatc acaggacgtt gctttttcac
2761 tgtttcctat taatcttcag ctgaacacaa gcaaaccttc tcaggaggtg tctcctaccc
2821 tcttattgtt cctcttacgc tctgctcaat gaaaccttcc tcttgagggt cattttcctt
2881 tctgtattaa ttataccagt gttaagtgac atagataaga actttgcaca cttcaaatca
2941 gagcagtgat tctctcttct ctcccctttt ccttcagagt gaatcatcca gactcctcat
3001 ggataggtcg ggtgttaaag ttgttttgat tatgtacctt ttgatagatc cacataaaaa
3061 gaaatgtgaa gttttctttt actatctttt catttatcaa gcagagacct ttgttgggag
3121 gcggtttggg agaacacatt tctaatttga atgaaatgaa atctattttc agtg
//