LOCUS HUMCCC5 5444 bp mRNA linear HUM 31-OCT-1994
DEFINITION Human complement component C5 mRNA, complete cds.
ACCESSION M57729
VERSION M57729.1
KEYWORDS complement component C5.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5444)
AUTHORS Haviland,D.L., Haviland,J.C., Fleischer,D.T., Hunt,A. and
Wetsel,R.A.
TITLE Complete cDNA sequence of human complement pro-C5. Evidence of
truncated transcripts derived from a single copy gene
JOURNAL J. Immunol. 146 (1), 362-368 (1991)
PUBMED 1984448
COMMENT Original source text: Human hepatocyte, cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..5444
/db_xref="H-InvDB:HIT000195837"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="9q33"
/cell_type="hepatocyte"
/tissue_type="liver"
gene 1..5444
/gene="C5"
CDS 13..5043
/gene="C5"
/codon_start=1
/product="complement component C5"
/protein_id="AAA51925.1"
/db_xref="GDB:G00-119-734"
/translation="MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVY
GYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYV
YLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETV
LTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFE
VKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLK
DDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTG
GFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVILNA
QTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQARE
GYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGK
IIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEK
CGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVF
QFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKK
IEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRA
NISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWE
IQGIGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFC
VKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSL
ETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTE
IKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNH
WNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQ
VNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTA
FTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQ
FRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLK
DINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHK
GALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFY
LKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANE
EDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFT
VYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTA
CKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAE
LVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFA
EDIFLNGC"
sig_peptide 13..66
/gene="C5"
/note="G00-119-734"
mat_peptide 67..2031
/gene="C5"
/product="complement component C5"
/note="beta-chain; G00-119-734"
mat_peptide 2044..5040
/gene="C5"
/product="complement component C5"
/note="alpha-chain; G00-119-734"
regulatory 5423..5428
/regulatory_class="TATA_box"
/gene="C5"
/note="G00-119-734"
BASE COUNT 1735 a 1053 c 1119 g 1537 t
ORIGIN
1 ctacctccaa ccatgggcct tttgggaata ctttgttttt taatcttcct ggggaaaacc
61 tggggacagg agcaaacata tgtcatttca gcaccaaaaa tattccgtgt tggagcatct
121 gaaaatattg tgattcaagt ttatggatac actgaagcat ttgatgcaac aatctctatt
181 aaaagttatc ctgataaaaa atttagttac tcctcaggcc atgttcattt atcctcagag
241 aataaattcc aaaactctgc aatcttaaca atacaaccaa aacaattgcc tggaggacaa
301 aacccagttt cttatgtgta tttggaagtt gtatcaaagc atttttcaaa atcaaaaaga
361 atgccaataa cctatgacaa tggatttctc ttcattcata cagacaaacc tgtttatact
421 ccagaccagt cagtaaaagt tagagtttat tcgttgaatg acgacttgaa gccagccaaa
481 agagaaactg tcttaacctt catagatcct gaaggatcag aagttgacat ggtagaagaa
541 attgatcata ttggaattat ctcttttcct gacttcaaga ttccgtctaa tcctagatat
601 ggtatgtgga cgatcaaggc taaatataaa gaggactttt caacaactgg aaccgcatat
661 tttgaagtta aagaatatgt cttgccacat ttttctgtct caatcgagcc agaatataat
721 ttcattggtt acaagaactt taagaatttt gaaattacta taaaagcaag atatttttat
781 aataaagtag tcactgaggc tgacgtttat atcacatttg gaataagaga agacttaaaa
841 gatgatcaaa aagaaatgat gcaaacagca atgcaaaaca caatgttgat aaatggaatt
901 gctcaagtca catttgattc tgaaacagca gtcaaagaac tgtcatacta cagtttagaa
961 gatttaaaca acaagtacct ttatattgct gtaacagtca tagagtctac aggtggattt
1021 tctgaagagg cagaaatacc tggcatcaaa tatgtcctct ctccctacaa actgaatttg
1081 gttgctactc ctcttttcct gaagcctggg attccatatc ccatcaaggt gcaggttaaa
1141 gattcgcttg accagttggt aggaggagtc ccagtaatac tgaatgcaca aacaattgat
1201 gtaaaccaag agacatctga cttggatcca agcaaaagtg taacacgtgt tgatgatgga
1261 gtagcttcct ttgtgcttaa tctcccatct ggagtgacgg tgctggagtt taatgtcaaa
1321 actgatgctc cagatcttcc agaagaaaat caggccaggg aaggttaccg agcaatagca
1381 tactcatctc tcagccaaag ttacctttat attgattgga ctgataacca taaggctttg
1441 ctagtgggag aacatctgaa tattattgtt acccccaaaa gcccatatat tgacaaaata
1501 actcactata attacttgat tttatccaag ggcaaaatta tccattttgg cacgagggag
1561 aaattttcag atgcatctta tcaaagtata aacattccag taacacagaa catggttcct
1621 tcatcccgac ttctggtcta ttatatcgtc acaggagaac agacagcaga attagtgtct
1681 gattcagtct ggttaaatat tgaagaaaaa tgtggcaacc agctccaggt tcatctgtct
1741 cctgatgcag atgcatattc tccaggccaa actgtgtctc ttaatatggc aactggaatg
1801 gattcctggg tggcattagc agcagtggac agtgctgtgt atggagtcca aagaggagcc
1861 aaaaagccct tggaaagagt atttcaattc ttagagaaga gtgatctggg ctgtggggca
1921 ggtggtggcc tcaacaatgc caatgtgttc cacctagctg gacttacctt cctcactaat
1981 gcaaatgcag atgactccca agaaaatgat gaaccttgta aagaaattct caggccaaga
2041 agaacgctgc aaaagaagat agaagaaata gctgctaaat ataaacattc agtagtgaag
2101 aaatgttgtt acgatggagc ctgcgttaat aatgatgaaa cctgtgagca gcgagctgca
2161 cggattagtt tagggccaag atgcatcaaa gctttcactg aatgttgtgt cgtcgcaagc
2221 cagctccgtg ctaatatctc tcataaagac atgcaattgg gaaggctaca catgaagacc
2281 ctgttaccag taagcaagcc agaaattcgg agttattttc cagaaagctg gttgtgggaa
2341 gttcatcttg ttcccagaag aaaacagttg cagtttgccc tacctgattc tctaaccacc
2401 tgggaaattc aaggcattgg catttcaaac actggtatat gtgttgctga tactgtcaag
2461 gcaaaggtgt tcaaagatgt cttcctggaa atgaatatac catattctgt tgtacgagga
2521 gaacagatcc aattgaaagg aactgtttac aactatagga cttctgggat gcagttctgt
2581 gttaaaatgt ctgctgtgga gggaatctgc acttcggaaa gcccagtcat tgatcatcag
2641 ggcacaaagt cctccaaatg tgtgcgccag aaagtagagg gctcctccag tcacttggtg
2701 acattcactg tgcttcctct ggaaattggc cttcacaaca tcaatttttc actggagact
2761 tggtttggaa aagaaatctt agtaaaaaca ttacgagtgg tgccagaagg tgtcaaaagg
2821 gaaagctatt ctggtgttac tttggatcct aggggtattt atggtaccat tagcagacga
2881 aaggagttcc catacaggat acccttagat ttggtcccca aaacagaaat caaaaggatt
2941 ttgagtgtaa aaggactgct tgtaggtgag atcttgtctg cagttctaag tcaggaaggc
3001 atcaatatcc taacccacct ccccaaaggg agtgcagagg cggagctgat gagcgttgtc
3061 ccagtattct atgtttttca ctacctggaa acaggaaatc attggaacat ttttcattct
3121 gacccattaa ttgaaaagca gaaactgaag aaaaaattaa aagaagggat gttgagcatt
3181 atgtcctaca gaaatgctga ctactcttac agtgtgtgga agggtggaag tgctagcact
3241 tggttaacag cttttgcttt aagagtactt ggacaagtaa ataaatacgt agagcagaac
3301 caaaattcaa tttgtaattc tttattgtgg ctagttgaga attatcaatt agataatgga
3361 tctttcaagg aaaattcaca gtatcaacca ataaaattac agggtacctt gcctgttgaa
3421 gcccgagaga acagcttata tcttacagcc tttactgtga ttggaattag aaaggctttc
3481 gatatatgcc ccctggtgaa aatcgacaca gctctaatta aagctgacaa ctttctgctt
3541 gaaaatacac tgccagccca gagcaccttt acattggcca tttctgcgta tgctctttcc
3601 ctgggagata aaactcaccc acagtttcgt tcaattgttt cagctttgaa gagagaagct
3661 ttggttaaag gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac
3721 agctctgtac ctaacactgg tacggcacgt atggtagaaa caactgccta tgctttactc
3781 accagtctga acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa
3841 gagcagaggt atggaggtgg cttttattca acccaggaca ccatcaatgc cattgagggc
3901 ctgacggaat attcactcct ggttaaacaa ctccgcttga gtatggacat cgatgtttct
3961 tacaagcata aaggtgcctt acataattat aaaatgacag acaagaattt ccttgggagg
4021 ccagtagagg tgcttctcaa tgatgacctc attgtcagta caggatttgg cagtggcttg
4081 gctacagtac atgtaacaac tgtagttcac aaaaccagta cctctgagga agtttgcagc
4141 ttttatttga aaatcgatac tcaggatatt gaagcatccc actacagagg ctacggaaac
4201 tctgattaca aacgcatagt agcatgtgcc agctacaagc ccagcaggga agaatcatca
4261 tctggatcct ctcatgcggt gatggacatc tccttgccta ctggaatcag tgcaaatgaa
4321 gaagacttaa aagcccttgt ggaaggggtg gatcaactat tcactgatta ccaaatcaaa
4381 gatggacatg ttattctgca actgaattcg attccctcca gtgatttcct ttgtgtacga
4441 ttccggatat ttgaactctt tgaagttggg tttctcagtc ctgccacttt cacagtttac
4501 gaataccaca gaccagataa acagtgtacc atgttttata gcacttccaa tatcaaaatt
4561 cagaaagtct gtgaaggagc cgcgtgcaag tgtgtagaag ctgattgtgg gcaaatgcag
4621 gaagaattgg atctgacaat ctctgcagag acaagaaaac aaacagcatg taaaccagag
4681 attgcatatg cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag
4741 tacaaggcaa cccttctgga tatctacaaa actggggaag ctgttgctga gaaagactct
4801 gagattacct tcattaaaaa ggtaacctgt actaacgctg agctggtaaa aggaagacag
4861 tacttaatta tgggtaaaga agccctccag ataaaataca atttcagttt caggtacatc
4921 taccctttag attccttgac ctggattgaa tactggccta gagacacaac atgttcatcg
4981 tgtcaagcat ttttagctaa tttagatgaa tttgccgaag atatcttttt aaatggatgc
5041 taaaattcct gaagttcagc tgcatacagt ttgcacttat ggactcctgt tgttgaagtt
5101 cgtttttttg ttttcttctt tttttaaaca ttcatagctg gtcttatttg taaagctcac
5161 tttacttaga attagtggca cttgctttta ttagagaatg atttcaaatg ctgtaacttt
5221 ctgaaataac atggccttgg agggcatgaa gacagatact cctccaaggt tattggacac
5281 cggaaacaat aaattggaac acctcctcaa acctaccact caggaatgtt tgctggggcc
5341 gaaagaacag tccattgaaa gggagtatta caaaaacatg gcctttgctt gaaagaaaat
5401 accaaggaac aggaaactga tcattaaagc ctgagtttgc tttc
//