LOCUS       HUMP53MUT                 72 bp    mRNA    linear   HUM 27-APR-1993
DEFINITION  Human p53 protein intronic point mutation at the splice donor site
            at the 3' end of exon 7. resulting in the retention of intron 7
            sequence in H647 mRNA.
ACCESSION   M55576
VERSION     M55576.1
KEYWORDS    p53 gene.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 72)
  AUTHORS   Takahashi,T., D'Amico,D., Chiba,I., Buchhagen,D.L. and Minna,J.D.
  TITLE     Identification of intronic point mutations as an alternative
            mechanism for p53 inactivation in lung cancer
  JOURNAL   J. Clin. Invest. 86 (1), 363-369 (1990)
   PUBMED   2164047
COMMENT     Original source text: Human lung cancer cell line H647, cDNA to
            mRNA.
FEATURES             Location/Qualifiers
     source          1..72
                     /db_xref="H-InvDB:HIT000195796"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_line="H647"
                     /tissue_type="adenosquamous cell lung cancer"
     gene            1..72
                     /gene="p23"
     exon            1..5
                     /gene="p23"
     variation       6
                     /gene="p23"
                     /note="g in wt; t in cancer cell line H647 causing a
                     readthrough of the exon/intron boundary at exon 7/intron 7
                     and ending at a premature stop codon at position 69."
BASE COUNT            9 a           33 c           15 g           15 t
ORIGIN      
        1 tccaggtcag gagccacttg ccaccctgca cactggcctg ctgtgcccca ccctctgctt
       61 gccctctgac cc
//