LOCUS HUMKRASM 5775 bp mRNA linear HUM 17-OCT-2008
DEFINITION Homo sapiens K-ras oncogene protein (KRAS) mRNA, complete cds.
ACCESSION M54968 M38506
VERSION M54968.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5775)
AUTHORS Kahn,S., Yamamoto,F., Almoguera,C., Winter,E., Forrester,K.,
Jordano,J. and Perucho,M.
TITLE The c-K-ras gene and human cancer (review)
JOURNAL Anticancer Res. 7 (4A), 639-652 (1987)
PUBMED 3310850
REFERENCE 2 (bases 1 to 5775)
AUTHORS Kahn,S., Yamamoto,F., Almoguera,C., Winter,E., Forrester,K.,
Jordano,J. and Perucho,M.
TITLE Direct Submission
JOURNAL Submitted (27-APR-1993) Department of Biochemistry, State
University of New York at Stony Brook, Stony Brook, NY, USA
COMMENT On Feb 4, 1997 this sequence version replaced gi:186763.
FEATURES Location/Qualifiers
source 1..5775
/db_xref="H-InvDB:HIT000195757"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="tumor"
gene 1..5775
/gene="KRAS"
/note="K-ras"
CDS 193..759
/gene="KRAS"
/codon_start=1
/product="K-ras oncogene protein"
/protein_id="AAB41942.1"
/translation="MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQV
VIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKR
VKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLV
REIRKHKEKMSKDGKKKKKKSKTKCVIM"
repeat_region 3031..3289
/gene="KRAS"
/rpt_family="Alu repetitive sequence"
regulatory 3601..3606
/regulatory_class="polyA_signal_sequence"
/gene="KRAS"
regulatory 5297..5302
/regulatory_class="polyA_signal_sequence"
/gene="KRAS"
polyA_site 5315
/gene="KRAS"
BASE COUNT 1739 a 974 c 1105 g 1957 t
ORIGIN
1 tcctaggcgg cggccgcggc ggcggaggca gcagcggcgg cggcagtggc ggcggcgaag
61 gtggcggcgg ctcggccagt actcccggcc cccgccattt cggactggga gcgagcgcgg
121 cgcaggcact gaaggcggcg gcggggccag aggctcagcg gctcccaggt gcgggagaga
181 ggcctgctga aaatgactga atataaactt gtggtagttg gagcttgtgg cgtaggcaag
241 agtgccttga cgatacagct aattcagaat cattttgtgg acgaatatga tccaacaata
301 gaggattcct acaggaagca agtagtaatt gatggagaaa cctgtctctt ggatattctc
361 gacacagcag gtcaagagga gtacagtgca atgagggacc agtacatgag gactggggag
421 ggctttcttt gtgtatttgc cataaataat actaaatcat ttgaagatat tcaccattat
481 agagaacaaa ttaaaagagt taaggactct gaagatgtac ctatggtcct agtaggaaat
541 aaatgtgatt tgccttctag aacagtagac acaaaacagg ctcaggactt agcaagaagt
601 tatggaattc cttttattga aacatcagca aagacaagac agggtgttga tgatgccttc
661 tatacattag ttcgagaaat tcgaaaacat aaagaaaaga tgagcaaaga tggtaaaaag
721 aagaaaaaga agtcaaagac aaagtgtgta attatgtaaa tacaatttgt acttttttct
781 taaggcatac tagtacaagt ggtaattttt gtacattaca ctaaattatt agcatttgtt
841 ttagcattac ctaatttttt tcctgctcca tgcagactgt tagcttttac cttaaatgct
901 tattttaaaa tgacagtgga agtttttttt tcctcgaagt gccagtattc ccagagtttt
961 ggtttttgaa ctagcaatgc ctgtgaaaaa gaaactgaat acctaagatt tctgtcttgg
1021 ggtttttggt gcatgcagtt gattacttct tatttttctt accaagtgtg aatgttggtg
1081 tgaaacaaat taatgaagct tttgaatcat ccctattctg tgttttatct agtcacataa
1141 atggattaat tactaatttc agttgagacc ttctaattgg tttttactga aacattgagg
1201 gacacaaatt tatgggcttc ctgatgatga ttcttctagg catcatgtcc tatagtttgt
1261 catccctgat gaatgtaaag ttacactgtt cacaaaggtt ttgtctcctt tccactgcta
1321 ttagtcatgg tcactctccc caaaatatta tattttttct ataaaaagaa aaaaatggaa
1381 aaaaattaca aggcaatgga aactattata aggccatttc cttttcacat tagataaatt
1441 actataaaga ctcctaatag ctttttcctg ttaaggcaga cccagtatga atgggattat
1501 tatagcaacc attttggggc tatatttaca tgctactaaa tttttataat aattgaaaag
1561 attttaacaa gtataaaaaa attctcatag gaattaaatg tagtctccct gtgtcagact
1621 gctctttcat agtataactt taaatctttt cttcaacttg agtctttgaa gatagtttta
1681 attctgcttg tgacattaaa agattatttg ggccagttat agcttattag gtgttgaaga
1741 gaccaaggtt gcaagccagg ccctgtgtga accttgagct ttcatagaga gtttcacagc
1801 atggactgtg tgccccacgg tcatccgagt ggttgtacga tgcattggtt agtcaaaaat
1861 ggggagggac tagggcagtt tggatagctc aacaagatac aatctcactc tgtggtggtc
1921 ctgctgacaa atcaagagca ttgcttttgt ttcttaagaa aacaaactct tttttaaaaa
1981 ttacttttaa atattaactc aaaagttgag attttggggt ggtggtgtgc caagacatta
2041 attttttttt taaacaatga agtgaaaaag ttttacaatc tctaggtttg gctagttctc
2101 ttaacactgg ttaaattaac attgcataaa cacttttcaa gtctgatcca tatttaataa
2161 tgctttaaaa taaaaataaa aacaatcctt ttgataaatt taaaatgtta cttattttaa
2221 aataaatgaa gtgagatggc atggtgaggt gaaagtatca ctggactagg ttgttggtga
2281 cttaggttct agataggtgt cttttaggac tctgattttg aggacatcac ttactatcca
2341 tttcttcatg ttaaaagaag tcatctcaaa ctcttagttt ttttttttta cactatgtga
2401 tttatattcc atttacataa ggatacactt atttgtcaag ctcagcacaa tctgtaaatt
2461 tttaacctat gttacaccat cttcagtgcc agtcttgggc aaaattgtgc aagaggtgaa
2521 gtttatattt gaatatccat tctcgtttta ggactcttct tccatattag tgtcatcttg
2581 cctccctacc ttccacatgc cccatgactt gatgcagttt taatacttgt aattccccta
2641 accataagat ttactgctgc tgtggatatc tccatgaagt tttcccactg agtcacatca
2701 gaaatgccct acatcttatt ttcctcaggg ctcaagagaa tctgacagat accataaagg
2761 gatttgacct aatcactaat tttcaggtgg tggctgatgc tttgaacatc tctttgctgc
2821 ccaatccatt agcgacagta ggatttttca accctggtat gaatagacag aaccctatcc
2881 agtggaagga gaatttaata aagatagtgc agaaagaatt ccttaggtaa tctataacta
2941 ggactactcc tggtaacagt aatacattcc attgttttag taaccagaaa tcttcatgca
3001 atgaaaaata ctttaattca tgaagcttac tttttttttt ttggtgtcag agtctcgctc
3061 ttgtcaccca ggctggaatg cagtggcgcc atctcagctc actgcaacct tccatcttcc
3121 caggttcaag cgattctcgt gcctcggcct cctgagtagc tgggattaca ggcgtgtgca
3181 ctacactcaa ctaatttttg tatttttagg agagacgggg tttcacctgt tggccaggct
3241 ggtctcgaac tcctgacctc aagtgattca cccaccttgg cctcataaac ctgttttgca
3301 gaactcattt attcagcaaa tatttattga gtgcctacca gatgccagtc accgcacaag
3361 gcactgggta tatggtatcc ccaaacaaga gacataatcc cggtccttag gtactgctag
3421 tgtggtctgt aatatcttac taaggccttt ggtatacgac ccagagataa cacgatgcgt
3481 attttagttt tgcaaagaag gggtttggtc tctgtgccag ctctataatt gttttgctac
3541 gattccactg aaactcttcg atcaagctac tttatgtaaa tcacttcatt gttttaaagg
3601 aataaacttg attatattgt ttttttattt ggcataactg tgattctttt aggacaatta
3661 ctgtacacat taaggtgtat gtcagatatt catattgacc caaatgtgta atattccagt
3721 tttctctgca taagtaatta aaatatactt aaaaattaat agttttatct gggtacaaat
3781 aaacagtgcc tgaactagtt cacagacaag ggaaacttct atgtaaaaat cactatgatt
3841 tctgaattgc tatgtgaaac tacagatctt tggaacactg tttaggtagg gtgttaagac
3901 ttgacacagt acctcgtttc tacacagaga aagaaatggc catacttcag gaactgcagt
3961 gcttatgagg ggatatttag gcctcttgaa tttttgatgt agatgggcat ttttttaagg
4021 tagtggttaa ttacctttat gtgaactttg aatggtttaa caaaagattt gtttttgtag
4081 agattttaaa gggggagaat tctagaaata aatgttacct aattattaca gccttaaaga
4141 caaaaatcct tgttgaagtt tttttaaaaa aagactaaat tacatagact taggcattaa
4201 catgtttgtg gaagaatata gcagacgtat attgtatcat ttgagtgaat gttcccaagt
4261 aggcattcta ggctctattt aactgagtca cactgcatag gaatttagaa cctaactttt
4321 ataggttatc aaaactgttg tcaccattgc acaattttgt cctaatatat acatagaaac
4381 tttgtggggc atgttaagtt acagtttgca caagttcatc tcatttgtat tccattgatt
4441 tttttttttc ttctaaacat tttttcttca aaacagtata tataactttt tttaggggat
4501 tttttttaga cagcaaaaaa ctatctgaag atttccattt gtcaaaaagt aatgatttct
4561 tgataattgt gtagtgaatg ttttttagaa cccagcagtt accttgaaag ctgaatttat
4621 atttagtaac ttctgtgtta atactggata gcatgaattc tgcattgaga aactgaatag
4681 ctgtcataaa atgctttctt tcctaaagaa agatactcac atgagttctt gaagaatagt
4741 cataactaga ttaagatctg tgttttagtt taatagtttg aagtgcctgt ttgggataat
4801 gataggtaat ttagatgaat ttaggggaaa aaaaagttat ctgcagttat gttgagggcc
4861 catctctccc cccacacccc cacagagcta actgggttac agtgttttat ccgaaagttt
4921 ccaattccac tgtcttgtgt tttcatgttg aaaatacttt tgcatttttc ctttgagtgc
4981 caatttctta ctagtactat ttcttaatgt aacatgttta cctggcctgt cttttaacta
5041 tttttgtata gtgtaaactg aaacatgcac attttgtaca ttgtgctttc ttttgtgggt
5101 catatgcagt gtgatccagt tgttttccat catttggttg cgctgaccta ggaatgttgg
5161 tcatatcaaa cattaaaaat gaccactctt ttaatgaaat taacttttaa atgtttatag
5221 gagtatgtgc tgtgaagtga tctaaaattt gtaatatttt tgtcatgaac tgtactactc
5281 ctaattattg taatgtaata aaaatagtta cagtgactat gagtgtgtat ttattcatgc
5341 aaatttgaac tgtttgcccc gaaatggata tggatacttt ataagccata gacactatag
5401 tataccagtg aatcttttat gcagcttgtt agaagtatcc ttttattttc taaaaggtgc
5461 tgtggatatt atgtaaaggc gtgtttgctt aaacaatttt ccatatttag aagtagatgc
5521 aaaacaaatc tgcctttatg acaaaaaaat aggataacat tatttattta tttcctttta
5581 tcaataaggt aattgataca caacaggtga cttggtttta ggcccaaagg tagcagcagc
5641 aacattaata atggaaataa ttgaatagtt agttatgtat gttaatgcca gtcaccagca
5701 ggctatttca aggtcagaag taatgactcc atacatatta tttatttcta taactacatt
5761 taaatcatta ccagg
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