LOCUS HUMNNAR 1910 bp mRNA linear HUM 07-JAN-1995
DEFINITION Human alpha-3 neuronal nicotinic acetylcholine receptor subunit
mRNA, complete cds.
ACCESSION M37981
VERSION M37981.1
KEYWORDS neuronal nicotinic acetylcholine receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1910)
AUTHORS Mihovilovic,M. and Roses,A.D.
TITLE Expression of mRNAs in human thymus coding for the alpha 3 subunit
of a neuronal acetylcholine receptor
JOURNAL Exp. Neurol. 111 (2), 175-180 (1991)
PUBMED 1989896
COMMENT Original source text: Homo sapiens thymus cDNA to mRNA.
Draft entry and computer-readable sequence for [J. Exp. Neurol.
(1990) In press] kindly submitted
by M.Mihovilovic, 24-AUG-1990.
FEATURES Location/Qualifiers
source 1..1910
/db_xref="H-InvDB:HIT000195731"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="15"
/tissue_type="thymus"
gene 1..1910
/gene="CHRNA3"
CDS 70..1581
/gene="CHRNA3"
/codon_start=1
/product="neuronal nicotinic acetylcholine receptor"
/protein_id="AAA59942.1"
/db_xref="GDB:G00-125-219"
/translation="MALAALAAPGAVAPRLLLLLLSLLPVARASEAEHRLFERLFEDY
NEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYG
GAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKID
VTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIK
YNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCIS
VLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTH
TMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEG
YPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIA
ENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA"
sig_peptide 70..156
/gene="CHRNA3"
mat_peptide 157..1578
/gene="CHRNA3"
/product="neuronal nicotinic acetylcholine receptor"
BASE COUNT 472 a 536 c 459 g 443 t
ORIGIN
1 ggggccgtct ctgcgaccgc cgcgcccgct cccgaccgtc cgggtccgcg gccagcccgg
61 ccaccagcca tggctctggc cgctctcgct gcccctggcg ctgtcgcgcc gcggctgctg
121 ctgctgctgc tgtctctgct gccagtggcc agggcctcag aggctgagca ccgtctattt
181 gagcggctgt ttgaagatta caatgagatc atccggcctg tagccaacgt gtctgaccca
241 gtcatcatcc atttcgaggt gtccatgtct cagctggtga aggtggatga agtaaaccag
301 atcatggaga ccaacctgtg gctcaagcaa atctggaatg actacaagct gaagtggaac
361 ccctctgact atggtggggc agagttcatg cgtgtccctg cacagaagat ctggaagcca
421 gacattgtgc tgtataacaa tgctgttggg gatttccagg tggacgacaa gaccaaagcc
481 ttactcaagt acactgggga ggtgacttgg atacctccgg ccatctttaa gagctcctgt
541 aaaatcgacg tgacctactt cccgtttgat taccaaaact gtaccatgaa gttcggttcc
601 tggtcctacg ataaggcgaa aatcgatctg gtcctgatcg gctcttccat gaacctcaag
661 gactattggg agagcggcga gtgggccatc atcaaagccc caggctacaa acacgacatc
721 aagtacaact gctgcgagga gatctacccc gacatcacat actcgctgta catccggcgc
781 ctgcccttgt tctacaccat caacctcatc atcccctgcc tgctcatctc cttcctcact
841 gtgctcgtct tctacctgcc ctccgactgc ggtgagaagg tgaccctgtg catttctgtc
901 ctcctctccc tgacggtgtt tctcctggtg atcactgaga ccatcccttc cacctcgctg
961 gtcatccccc tgattggaga gtacctcctg ttcaccatga tttttgtaac cttgtccatc
1021 gtcatcaccg tcttcgtgct caacgtgcac tacagaaccc cgacgacaca cacaatgccc
1081 tcatgggtga agactgtatt cttgaacctg ctccccaggg tcatgttcat gaccaggcca
1141 acaagcaacg agggcaacgc tcagaagccg aggcccctct acggtgccga gctctcaaat
1201 ctgaattgct tcagccgcgc agagtccaaa ggctgcaagg agggttaccc ctgccaggac
1261 gggatgtgtg gttactgcca ccaccgcagg ataaaaatct ccaatttcag tgctaacctc
1321 acgagaagct ctagttctga atctgttgat gctgtgctgt ccctctctgc tttgtcacca
1381 gaaatcaaag aagccatcca aagtgtcaag tatattgctg aaaatatgaa agcacaaaat
1441 gaagccaaag agattcaaga tgattggaag tatgttgcca tggtgattga tcgtattttt
1501 ctgtgggttt tcaccctggt gtgcattcta gggacagcag gattgtttct gcaacccctg
1561 atggccaggg aagatgcata agcactaagc tgtgtgcctg cctgggagac ttccttgtgt
1621 cagggcagga ggaggctgct tcctagctgg agtgcaatgg cgtgatctca gctcaccgca
1681 acctccgcca cctgggttca agcgattctc ctgccgcagc ctcccaggta gctgggatta
1741 caggaacaaa aagcccaaga gatccaacaa ttgaaacgaa aagaaaagtc cacagaaaca
1801 tccgatcaag aacctgggct atgaatttcc aatcttcaac aacctgttag gaaaaaaata
1861 aaaatgcatt aaataattgt aaaaaaaaaa aaaaaaaaat ctagagtcga
//