LOCUS HUMXRCC1 2797 bp mRNA linear HUM 07-MAR-1995
DEFINITION Human DNA-repair protein (XRCC1) mRNA, complete cds.
ACCESSION M36089
VERSION M36089.1
KEYWORDS DNA repair protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2797)
AUTHORS Thompson,L.H., Brookman,K.W., Jones,N.J., Allen,S.A. and
Carrano,A.V.
TITLE Molecular cloning of the human XRCC1 gene, which corrects defective
DNA strand break repair and sister chromatid exchange
JOURNAL Mol. Cell. Biol. 10 (12), 6160-6171 (1990)
PUBMED 2247054
COMMENT Original source text: Human fibroblast (cell line GM637), cDNA to
mRNA, clone pXR1-30.
Draft entry and computer-readable sequence for [Unpublished (1990)]
kindly submitted
by L.H.Thompson, 06-JUL-1990.
Author Address: L.H.Thompson
Biomedical Sciences Division
Lawrence Livermore National Laboratory
P.O. Box 5507
Livermore, CA 94550.
FEATURES Location/Qualifiers
source 1..2797
/db_xref="H-InvDB:HIT000195661"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="19q13.2"
/clone="pXR1-30"
/cell_line="GM637"
/cell_type="fibroblast"
gene 1..2797
/gene="XRCC1"
misc_feature 91..124
/gene="XRCC1"
/note="AT tract"
misc_feature 158..163
/gene="XRCC1"
/note="GC box"
regulatory 206..211
/regulatory_class="CAAT_signal"
/gene="XRCC1"
regulatory complement(262..266)
/regulatory_class="CAAT_signal"
/note="CAAT box (reverse orientation)"
mRNA 444..2526
/gene="XRCC1"
/product="DNA-repair protein mRNA"
CDS 549..2450
/gene="XRCC1"
/note="DNA-repair protein"
/codon_start=1
/protein_id="AAA63270.1"
/db_xref="GDB:G00-120-737"
/translation="MPEIRLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTIS
VVLQLEKEEQIHSVDIGNDGSAFVEVLVGSSAGGAGEQDYEVLLVTSSFMSPSESRSG
SNPNRVRMFGPDKLVRAAAEKRWDRVKIVCSQPYSKDSPFGLSFVRFHSPPDKDEAEA
PSQKVTVTKLGQFRVKEEDESANSLRPGALFFSRINKTSPVTASDPAGPSYAAATLQA
SSAASSASPVSRAIGSTSKPQESPKGKRKLDLNQEEKKTPSKPPAQLSPSVPKRPKLP
APTRTPATAPVPARAQGAVTGKPRGEGTEPRRPRAGPEELGKILQGVVVVLSGFQNPF
RSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLDCHRM
RRRLPSRRYLMAGPGSSSEEDEASHSGGSGDEAPKLPQKQPQTKTKPTQAAGPSSPQK
PPTPEETKAASPVLQEDIDIEGVQSEGQDNGAEDSGDTEDELRRVAEQKEHRLPPGQE
ENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIRYV
TAFNGELEDYMSDRVQFVITAQEWDPSFEEALMDNPSLAFVRPRWIYSCNEKQKLLPH
QLYGVVPQA"
misc_feature 574..575
/gene="XRCC1"
/note="genomic DNA end/cDNA start"
regulatory 1359..1376
/regulatory_class="other"
/gene="XRCC1"
/note="nuclear location signal"
repeat_region 2463..2496
/gene="XRCC1"
/note="AC repeat"
regulatory 2506..2511
/regulatory_class="polyA_signal_sequence"
/gene="XRCC1"
misc_feature 2526..2527
/gene="XRCC1"
/note="cDNA end/genomic DNA start"
BASE COUNT 651 a 827 c 801 g 515 t
ORIGIN
1 tcccttggcc ccaggagaca ggggttgcag aaagccgaga tcgtgccact gcactccatc
61 ctgggtgaga gagcaagacc ctgtctcaac aaaaaatttt taaaaaataa aataaataat
121 aatacagcaa aaagatttgc tttctcggct tcagtgtggg cggtaactcc atcgtgcaat
181 gagaaaggcg aatttcttcc agacaccaat cccggaggtc gcttctgttg ctaggctccc
241 agaaagcagg gttcggacgt cattgggagg cgaggctaga gcggggttgt gtgtggcgga
301 gggaggcggg gctggaggaa acgctcgttg ctaaggaacg cagcgctctt cccgctctgg
361 agaggcgcga ctgggcttgc gcagtgtcga cgccggcgcc ggcgcgccgg ggtttgaaag
421 gcccgagcct cgcgcgcttg cgcactttag ccagcgcagg gcgcaccccg ctccctccca
481 ctctccctgc ccctcggacc ccatactcta cctcatcctt ctggccaggc gaagcccacg
541 acgttgacat gccggagatc cgcctccgcc atgtcgtgtc ctgcagcagc caggactcga
601 ctcactgtgc agaaaatctt ctcaaggcag acacttaccg aaaatggcgg gcagccaagg
661 caggcgagaa gaccatctct gtggtcctac agttggagaa ggaggagcag atacacagtg
721 tggacattgg gaatgatggc tcagctttcg tggaggtgct ggtgggcagt tcagctggag
781 gcgctgggga gcaagactat gaggtccttc tggtcacctc atctttcatg tccccttccg
841 agagccgcag tggctcaaac cccaaccgcg ttcgcatgtt tgggcctgac aagctggtcc
901 gggcagccgc cgagaagcgc tgggaccggg tcaaaattgt ttgcagccag ccctacagca
961 aggactcccc ctttggcttg agttttgtac ggtttcatag ccccccagac aaagatgagg
1021 cagaggcccc gtcccagaag gtgacagtga ccaagcttgg ccagttccgt gtgaaggagg
1081 aggatgagag cgccaactct ctgaggccgg gggctctctt cttcagccgg atcaacaaga
1141 catccccagt cacagccagc gacccggcag gacctagcta tgcagctgct accctccagg
1201 cttctagtgc tgcctcctca gcctctccag tctccagggc cataggcagc acctccaagc
1261 cccaggagtc tcccaaaggg aagaggaagt tggatttgaa ccaagaagaa aagaagaccc
1321 ccagcaaacc accagcccag ctgtcgccat ctgttcccaa gagacctaaa ttgccagctc
1381 caactcgtac cccagccaca gccccagtcc ctgcccgagc acagggggca gtgacaggca
1441 aaccccgagg agaaggcacc gagcccagac gaccccgagc tggcccagag gagctgggga
1501 agatccttca gggtgtggta gtggtgctga gtggcttcca gaaccccttc cgctccgagc
1561 tgcgagataa ggccctagag cttggggcca agtatcggcc agactggacc cgggacagca
1621 cgcacctcat ctgtgccttt gccaacaccc ccaagtacag ccaggtccta ggcctgggag
1681 gccgcatcgt gcgtaaggag tgggtgctgg actgtcaccg catgcgtcgg cggctgccct
1741 cccggaggta cctcatggca gggccaggtt ccagcagtga ggaggatgag gcctctcaca
1801 gcggtggcag cggagatgaa gcccccaagc ttcctcagaa gcaaccccag accaaaacca
1861 agcccactca ggcagctgga cccagctcac cccagaagcc cccaacccct gaagagacca
1921 aagcagcctc accagtgctc caggaagata tagacattga gggggtacag tcagaaggac
1981 aggacaatgg ggcggaagat tctggggaca cagaggatga gctgaggagg gtggcagagc
2041 agaaggaaca cagactgccc cctggccagg aggagaatgg ggaagacccg tatgcaggct
2101 ccacggatga gaacacggac agtgaggaac accaggagcc tcctgatctg ccagtccctg
2161 agctcccaga tttcttccag ggcaagcact tctttcttta cggggagttc cctggggacg
2221 agcggcggaa actcatccga tacgtcacag ccttcaatgg ggagctcgag gactatatga
2281 gtgaccgggt tcagtttgtg atcacagcac aggaatggga tcccagcttt gaggaggccc
2341 tgatggacaa cccctccctg gcattcgttc gtccccgatg gatctacagt tgcaatgaga
2401 agcagaagtt acttcctcac cagctctatg gggtggtgcc gcaagcctga agtatgtgct
2461 atacacacac acacacacac acacacacac acacacgatg catttaataa agatgagttg
2521 gttctcatcc aagagtctcc caaaactcta agaggctccc tgggacctgg ggaagaatgc
2581 tgggcacctc cgtcagagat ctggtacaca aggaactctt tgtctcttct gcttggcccc
2641 ttatccctgt gttggcaaga ggcagggaac tgggaatctg accctcagca ctgcccctca
2701 actttttctg gccctctgag ccacacctgt atcttggctg tccctttgtg gctggassst
2761 gggtacccat gaggcttgtc tctctcctga agcctca
//