LOCUS HUM3BHSD 1565 bp mRNA linear HUM 30-OCT-1994
DEFINITION Human placental 3-beta-hydroxysteroid dehydrogenase/5-4-isomerase
mRNA, complete cds.
ACCESSION M35493
VERSION M35493.1
KEYWORDS 3-beta-hydroxysteroid dehydrogenase/5-4-isomerase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1565)
AUTHORS Lorence,M.C., Murry,B.A., Trant,J.M. and Mason,J.I.
TITLE Human 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase
from placenta: expression in nonsteroidogenic cells of a protein
that catalyzes the dehydrogenation/isomerization of C21 and C19
steroids
JOURNAL Endocrinology 126 (5), 2493-2498 (1990)
PUBMED 2139411
COMMENT Original source text: Human placenta, cDNA to mRNA, clone
H3-beta-hp6.
FEATURES Location/Qualifiers
source 1..1565
/db_xref="H-InvDB:HIT000195637"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="1p13.1"
gene 1..1565
/gene="HSD3B"
mRNA <1..1565
/gene="HSD3B"
/note="3-beta-hydroxysteroid dehydrogenase/5-4-isomerase;
G00-120-056"
CDS 31..1152
/gene="HSD3B"
/note="3-beta-hydroxysteroid dehydrogenase/5-4-isomerase"
/codon_start=1
/protein_id="AAA51538.1"
/db_xref="GDB:G00-120-056"
/translation="MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELR
EEFSKLQNKTKLTVLEGDILDEPFLKRACQDVSVIIHTACIIDVFGVTHRESIMNVNV
KGTQLLLEACVQASVPVFIYTSSIEVAGPNSYKEIIQNGHEEEPLENTWPAPYPHSKK
LAEKAVLAANGWNLKNGGTLYTCALRPMYIYGEGSRFLSASINEALNNNGILSSVGKF
STVNPVYVGNVAWAHILALRALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEF
GLRLDSRWSFPLSLMYWIGFLLEIVSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKA
QRDLAYKPLYSWEEAKQKTVEWVGSLVDRHKETLKSKTQ"
BASE COUNT 417 a 381 c 376 g 391 t
ORIGIN
1 gcggagtgat tcctgctact ttggatggcc atgacgggct ggagctgcct tgtgacagga
61 gcaggagggt ttctgggaca gaggatcatc cgcctcttgg tgaaggagaa ggagctgaag
121 gagatcaggg tcttggacaa ggccttcgga ccagaattga gagaggaatt ttctaaactc
181 cagaacaaga ccaagctgac agtgctggaa ggagacattc tggatgagcc attcctgaag
241 agagcctgcc aggacgtctc ggtcatcatc cacaccgcct gtatcattga tgtcttcggt
301 gtcactcaca gagagtctat catgaatgtc aatgtgaaag gtacccagct cctgttagag
361 gcctgtgtcc aagctagtgt gccagtcttc atctacacca gtagcataga ggtagccggg
421 cccaactcct acaaggaaat catccagaat ggccatgaag aagagcctct ggaaaacaca
481 tggcccgctc catacccaca cagcaaaaag cttgctgaga aggctgtact ggcggctaac
541 gggtggaatc tgaaaaacgg cggcaccctg tacacttgtg ccttacgacc catgtatatc
601 tatggggaag gaagccgatt cctttctgct agtataaacg aggccctgaa caacaatggg
661 atcctgtcaa gtgttggaaa gttctccact gttaacccag tctatgttgg caatgtggcc
721 tgggcccaca ttctggcctt gagggccctg caggacccca agaaggcccc aagcatccga
781 ggacagttct actatatctc agatgacacg cctcaccaaa gctatgataa ccttaattac
841 accctgagca aagagttcgg cctccgcctt gattccagat ggagctttcc tttatccctg
901 atgtattgga ttggcttcct gctggaaata gtgagcttcc tactcaggcc aatttacacc
961 tatcgaccgc ccttcaaccg ccacatagtc acattgtcaa atagcgtatt caccttctct
1021 tataagaagg ctcagcgaga tctggcgtat aagccactct acagctggga ggaagccaag
1081 cagaaaacgg tggagtgggt tggttccctt gtggaccggc acaaggagac cctgaagtcc
1141 aagactcagt gatttaagga tgacagagat gtgcatgtgg gtattgttag gagatgtcat
1201 caagctccac cctcctggcc tcatacagaa agtgacaagg gcacaagctc aggtcctgct
1261 gcctcccttt catacaatgg ccaacttatt gtattcctca tgtcatcaaa acctgcgcag
1321 tcattggccc aacaagaagg tttctgtcct aatcatatac cagaggaaag accatgtggt
1381 ttgctgttac caaatctcag tagctgattc tgaacaattt agggactctt ttaacttgag
1441 ggtcgttttg actactagag ctccatttct actcttaaat gagaaaggat ttcctttctt
1501 tttaatcttc cattccttca catagtttga taaaaagatc aataaatgtt tgaatgttta
1561 atgtg
//