LOCUS HUMARGCAA 3849 bp mRNA linear HUM 27-APR-1993
DEFINITION Human tyrosine kinase arg gene mRNA.
ACCESSION M35296
VERSION M35296.1
KEYWORDS tyrosine kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3849)
AUTHORS Kruh,G.D., Perego,R., Miki,T. and Aaronson,S.A.
TITLE The complete coding sequence of arg defines the Abelson subfamily
of cytoplasmic tyrosine kinases
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (15), 5802-5806 (1990)
PUBMED 2198571
COMMENT Original source text: Human cDNA to mRNA.
Authorin copy of sequence for [1] kindly submitted by G.D.Kruh,
19-JUN-1990, for release after publication.
FEATURES Location/Qualifiers
source 1..3849
/db_xref="H-InvDB:HIT000195630"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 205..3753
/note="arg tyrosine kinase"
/codon_start=1
/protein_id="AAA35553.1"
/translation="MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTET
GFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLL
GATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSN
YITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVY
HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP
IHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA
VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ
ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIK
WTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPE
GCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVV
PYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALP
RKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKK
YELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGT
AGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMA
MTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRG
ATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWP
SPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDK
DRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAV
PISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEA
LLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELS
LQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR"
misc_feature 1045..1800
/note="tyrosine kinase domain of protein"
BASE COUNT 1018 a 983 c 1059 g 789 t
ORIGIN
1 aaaagcagaa tctgtgagtc gcctggaggc agcgcggcgg ctgccgtgag gaggccgggt
61 gcggagccgc cggtggccca gccgctcagg gccagggcct gggctgggag ggagagaccg
121 gagcagcgcc aggagcccga ggccggagcc gaggaggaat gtgaccaggg gtcggcgggg
181 gcgcgggagt acgcgagagc agggatgggg cagcaggtgg gccgcgtcgg ggaagctccg
241 gggctccagc agcctcagcc ccgcgggatc cggggcagca gtgcagccag gccctccggc
301 cgcaggcggg acccggcggg gcgcaccaca gagaccggct tcaatatctt cacccagcat
361 gatcactttg ccagctgtgt ggaggatgga tttgagggag acaagactgg aggcagtagt
421 ccagaagctt tgcatcgtcc ctatggttgt gatgttgaac cccaggcact aaatgaggct
481 atcaggtgga gctccaagga gaacttgctc ggagccactg agagtgaccc taatctcttc
541 gttgcacttt atgattttgt agcaagtggt gataacacac tcagcatcac taaaggtgaa
601 aagctacgag tccttggtta caaccagaat ggtgagtgga gtgaagttcg ctctaagaat
661 gggcagggct gggtgccaag caactacatc accccagtga acagcctgga aaaacactcc
721 tggtaccatg gacctgtgtc acgcagtgca gctgagtatc tgctcagcag tctaatcaat
781 ggcagcttcc tggtgcgaga aagtgagagt agccctgggc agctgtccat ctcgctcagg
841 tacgagggac gtgtgtatca ctacaggatc aataccactg cagatggcaa ggtgtatgtg
901 actgctgaga gccgcttcag caccttggca gagcttgtac accatcactc cacagtggct
961 gatgggctgg tgacaacatt acactaccca gcacccaagt gtaataagcc tacagtctat
1021 ggtgtgtccc ccatccacga caaatgggaa atggagcgaa cagatattac catgaagcac
1081 aaacttgggg gcggtcagta tggagaggtt tacgttggcg tctggaagaa atacagcctt
1141 acagttgctg tgaaaacatt gaaggaagat accatggagg tagaagaatt cctgaaagaa
1201 gctgcagtaa tgaaggaaat caagcatcct aatctggtac aacttttagg tgtgtgtact
1261 ttggagccac cattttacat tgtgactgaa tacatgccat acgggaattt gctggattac
1321 ctccgagaat gcaaccgaga agaggtgact gcagttgtgc tgctctacat ggccactcag
1381 atttcttctg caatggagta cttagagaag aagaatttca tccatagaga tcttgcagct
1441 cgtaactgcc tagtgggaga aaaccatgtg gtaaaagtgg ctgactttgg cttaagtaga
1501 ttgatgactg gagacactta tactgctcat gctggagcca aatttcctat taagtggaca
1561 gcaccagaga gtcttgccta caataccttc tcaattaaat ctgacgtctg ggcttttggg
1621 gtattgttgt gggaaattgc tacctatgga atgtcaccat atccaggtat tgacctgtct
1681 caggtctatg acctactaga aaaaggatat cgaatggaac agcctgaggg atgcccccct
1741 aaggtttatg aacttatgag agcatgctgg aagtggagcc ctgccgatag gccctctttt
1801 gctgaaacac accaagcttt tgaaaccatg ttccatgact ccagcatttc tgaagaggta
1861 gctgaggagc ttgggagagc cgcctcctcg tcatctgttg ttccatacct gccccggcta
1921 cctatacttc cttccaagac tcggacactg aagaaacagg tggagaacaa ggagaacatt
1981 gaaggggcac aagatgccac agaaaattct gcttccagtt tagcaccagg gttcatcaga
2041 ggtgcacagg cctctagtgg atccccagca ctgcctcgaa agcaaagaga caagtcaccc
2101 agcagcctct tggaagatgc caaagagaca tgcttcacca gggataggaa ggggggcttc
2161 ttcagctcct tcatgaagaa gagaaatgct cctacacccc ccaaacgcag cagctccttc
2221 cgagaaatgg agaatcagcc ccataagaaa tacgaactca cgggtaactt ctcatctgtt
2281 gcttctctac agcatgctga tgggttctct ttcactcctg cccagcaaga ggcgaatctg
2341 gtgccaccca agtgctatgg ggggagcttt gcacagagga acctctgtaa tgacgacggt
2401 ggtgggggtg ggggcagtgg cactgctggg ggtgggtggt ctggcatcac aggcttcttt
2461 acaccacgct taatcaaaaa gacactgggc ttacgagcag gtaaacccac agccagtgat
2521 gacacttcca agccttttcc aaggtcaaac tctacatctt ccatgtcctc agggcttcca
2581 gagcaggata ggatggcaat gacccttccc aggaactgcc agaggtccaa actccagctg
2641 gaaaggacag tgtccacctc ttctcagcca gaagagaatg tggacagggc caatgacatg
2701 cttccaaaaa aatcagagga aagtgctgct ccaagcaggg agagaccaaa agccaagtta
2761 ttgcccagag gagccacagc tcttcctctc agaacaccct ctggggatct agccattaca
2821 gagaaggacc ctccaggggt gggagtggct ggagtggcag ctgcccccaa gggtaaagag
2881 aagaatggtg gggcacgact tgggatggct ggagttccag aggatggaga gcagccgggc
2941 tggccttctc cagccaaggc tgcccccgtc ctcccaacca ctcacaacca caaagtgcca
3001 gtccttatct cacccactct gaaacacact ccagctgacg tgcagctcat tggcacagac
3061 tctcagggga ataaattcaa gctcttatct gagcatcagg tcacatcctc tggagacaag
3121 gaccgacccc gacgggtaaa accaaagtgt gccccacccc caccaccagt gatgagacta
3181 ctgcagcatc cgtccatctg ctcagaccct acagaagagc caactgccct aactgcagga
3241 cagtccacat cagaaacaca ggaaggagga aagaaggcag ctctgggcgc agtgcccatc
3301 agtgggaaag ctgggaggcc agtgatgcct ccacctcaag tgcctctgcc cacatcttcc
3361 atctcgccag ccaaaatggc caatggcaca gcaggtacta aagtggctct gagaaaaacc
3421 aaacaggccg ctgagaaaat ctcagcagac aaaatcagca aagaggccct gctggaatgt
3481 gctgacctac tgtccagtgc actcacggaa cctgtgccca acagccagct ggtagacact
3541 ggacaccagc tgcttgacta ctgctcaggc tatgtggact gcatccctca aactcgcaac
3601 aaatttgcct tccgagaggc tgtgagcaaa ctggaactca gcctgcagga gctacaggtt
3661 tcttcagcag ctgctggtgt gcccgggaca aaccctgtcc ttaataactt attgtcatgt
3721 gtacaggaaa tcagtgatgt ggtgcagagg tagccactgt tagcctggtg ggaaaatgca
3781 cacatttctg aggggagagg gaaaaggact tgttttcctg tgttcttgtt ttcagaaaat
3841 gaaagactc
//