LOCUS HUMPTPAAA 3615 bp mRNA linear HUM 27-APR-1993
DEFINITION Human protein tyrosine phosphatase (PTPase-alpha) mRNA.
ACCESSION M34668
VERSION M34668.1
KEYWORDS PTPase-alpha; protein-tyrosine phosphatase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3615)
AUTHORS Kaplan,R., Morse,B., Huebner,K., Croce,C., Howk,R., Ravera,M.,
Ricca,G., Jaye,M. and Schlessinger,J.
TITLE Cloning of three human tyrosine phosphatases reveals a multigene
family of receptor-linked protein-tyrosine-phosphatases expressed
in brain
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (18), 7000-7004 (1990)
PUBMED 2169617
COMMENT Original source text: Human neo-natal brain stem (ATCC 37432) clone
31-4 and clone 27-1.
Draft entry and computer-readable sequence kindly submitted by
R.Kaplan,
30-MAY-1990, for release after publication .
In PNASU 87, 6112, the sequence data was identified as M34668, when
this is
incorrect. The data for the aformentioned paper are retrievable by
the
citation.
FEATURES Location/Qualifiers
source 1..3615
/db_xref="H-InvDB:HIT000195609"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 696..3104
/note="protein tyrosine phosphatase (EC 3.1.3.48)"
/codon_start=1
/protein_id="AAA36528.1"
/translation="MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVK
EEAKTSNPTSSLTSLSVAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITIS
PNGTWLPDNQFTDARTEPWEGNSSTAATTPETFPPSGNSDSKDRRDETPIIAVMVALS
SLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKY
PPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILP
YDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTA
TIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMT
NRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTG
TFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTE
LEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQ
IIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEW
KSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTR
ENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTG
TFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDY
ANFK"
sig_peptide 696..749
/note="protein tyrosine phosphatase signal peptide"
mat_peptide 750..3101
/product="protein tyrosine phosphatase mature peptide"
BASE COUNT 1037 a 876 c 886 g 816 t
ORIGIN
1 gaattcgggg gagtaagaga cacgctcagg ggagcaggta ccccttctcc taaagatgaa
61 gaggagcaaa ctggcactaa gcaaggccat cgagagcggg gacactgacc tggtgttcac
121 ggtgttgctg cacctgaaga acgagctgaa ccgaggagat tttttcatga cccttcggaa
181 tcagcccatg gccctcagtt tgtaccgaca gttctgtaag catcaggagc tagagacgct
241 gaaggacctt tacaatcagg atgacaatca ccaggaattg ggcagcttcc acatccgagc
301 cagctatgct gcagaagagc gtattgaggg gcgagtagca gctctgcaga cagccgccga
361 tgccttctac aaggccaaga atgagtttgc agccaaggct acagaggatc aaatgcggct
421 cctacggctg cagcggcgcc tagaagacga gctggggggc cagttcctag acctgtctct
481 acatgacaca gttaccaccc tcattcttgg cggtcacaac aagcgtgcag agcagctggc
541 acgtgacttc cgcatccctg acaagaggtg acacaactaa aaaaaaacaa aggtatttat
601 ggaattccac tgagtggtaa tggatgatgc agttcaaata actaaggaca catgttcaaa
661 gagcataatt aactttttaa aagaagctaa caagcatgga ttcctggttc attcttgttc
721 tgctcggcag tggtctgata tgtgtcagtg ccaacaatgc taccacagtt gcaccttctg
781 taggaattac aagattaatt aactcatcaa cggcagaacc agttaaagaa gaggccaaaa
841 cttcaaatcc aacttcttca ctaacttctc tttctgtggc accaacattc agcccaaata
901 taactctggg acccacctat ttaaccactg tcaattcttc agactctgac aatgggacca
961 caagaacagc aagcaccaat tctataggca ttacaatttc accaaatgga acgtggcttc
1021 cagataacca gttcacggat gccagaacag aaccctggga ggggaattcc agcaccgcag
1081 caaccactcc agaaactttc cctccttcag gtaattctga ctcgaaggac agaagagatg
1141 agacaccaat tattgcggtg atggtggccc tgtcctctct gctagtgatc gtgtttatta
1201 tcatagtttt gtacatgtta aggtttaaga aatacaagca agctgggagc cattccaatt
1261 ctttccgctt atccaacggc cgcactgagg atgtggagcc ccagagtgtg ccacttctgg
1321 ccagatcccc aagcaccaac aggaaatacc cacccctgcc cgtggacaag ctggaagagg
1381 aaattaaccg gagaatggca gacgacaata agctcttcag ggaggaattc aacgctctcc
1441 ctgcatgtcc tatccaggcc acctgtgagg ctgcttccaa ggaggaaaac aaggaaaaaa
1501 atcgatatgt aaacatcttg ccttatgacc actctagagt ccacctgaca ccggttgaag
1561 gggttccaga ttctgattac atcaatgctt cattcatcaa cggttaccaa gaaaagaaca
1621 aattcattgc tgcacaagga ccaaaagaag aaacggtgaa tgatttctgg cggatgatct
1681 gggaacaaaa cacagccacc atcgtcatgg ttaccaacct gaaggagaga aaggagtgca
1741 agtgcgccca gtactggcca gaccaaggct gctggaccta tgggaatatt cgggtgtctg
1801 tagaggatgt gactgtcctg gtggactaca cagtacggaa gttctgcatc cagcaggtgg
1861 gcgacatgac caacagaaag ccacagcgcc tcatcactca gttccacttt accagctggc
1921 cagactttgg ggtgcctttt accccgatcg gcatgctcaa gttcctcaag aaggtgaagg
1981 cctgtaaccc tcagtatgca ggggccatcg tggtccactg cagtgcaggt gtagggcgta
2041 caggtacctt tgtcgtcatt gatgccatgc tggacatgat gcatacagaa cggaaggtgg
2101 acgtgtatgg ctttgtgagc cggatccggg cacagcgctg ccagatggtg caaaccgata
2161 tgcagtatgt cttcatatac caagcccttc tggagcatta tctctatgga gatacagaac
2221 tggaagtgac ctctctagaa acccacctgc agaaaattta caacaaaatc ccagggacca
2281 gcaacaatgg attagaggag gagtttaaga agttaacatc aatcaaaatc cagaatgaca
2341 agatgcggac tggaaacctt ccagccaaca tgaagaagaa ccgtgtttta cagatcattc
2401 catatgaatt caacagagtg atcattccag ttaagcgggg cgaagagaat acagactatg
2461 tgaacgcatc ctttattgat ggctaccggc agaaggactc ctatatcgcc agccagggcc
2521 ctcttctcca cacaattgag gacttctggc gaatgatctg ggagtggaaa tcctgctcta
2581 tcgtgatgct aacagaactg gaggagagag gccaggagaa gtgtgcccag tactggccat
2641 ctgatggact ggtgtcctat ggagatatta cagtggaact gaagaaggag gaggaatgtg
2701 agagctacac cgtccgagac ctcctggtca ccaacaccag ggagaataag agccggcaga
2761 tccggcagtt ccacttccat ggctggcctg aagtgggcat ccccagtgac ggaaagggca
2821 tgatcagcat catcgccgcc gtgcagaagc agcagcagca gtcagggaac caccccatca
2881 ccgtgcactg cagcgccggg gcaggaagga cggggacctt ctgtgccctg agcaccgtcc
2941 tggagcgtgt gaaagcagag gggattttgg atgtcttcca gactgtcaag agcctgcggc
3001 tacagaggcc acacatggtc cagacactgg aacagtatga gttctgctac aaggtggtgc
3061 aggagtatat tgatgcattc tcagattatg ccaacttcaa gtaagcggca acaagggtcc
3121 gtggaccagg aggattgcct ttaatatttt gtaatattct gttttgttaa tataccccaa
3181 attgtgtata tatcttataa ctgttttaga aattggtaca taggcttcta ttacctatta
3241 ggtggaaatt ttatatgtaa atgtgttagc actgatagtc ctttttccaa tgttttattg
3301 gggaattaaa tagtgtgatg tttggattga tatcgtgaaa tcctcagccg agaaattggg
3361 ctggattgcg ctttggttaa tacatctttc cctaaagaag ataaacacaa aatccattcc
3421 aggtagctcg gcaccaacta agaaaaaaag cacaaagttc tcagagctct cgaggaaagt
3481 ggttgtcccc gtaccaccat gcactgtaaa tatccctccc ctctctccct ggtcccctcc
3541 cccatcccca ccactgatat catggggagt aataggacca gagcggtatc tctggcacca
3601 cactagcccg aattc
//