LOCUS HUMPLCA 4408 bp mRNA linear HUM 27-APR-1993
DEFINITION Human phospholipase C-gamma mRNA, complete cds.
ACCESSION M34667
VERSION M34667.1
KEYWORDS phospholipase C-gamma.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4408)
AUTHORS Burgess,W.H., Dionne,C.A., Kaplow,J., Mudd,R., Friesel,R.,
Zilberstein,A., Schlessinger,J. and Jaye,M.
TITLE Characterization and cDNA cloning of phospholipase C-gamma, a major
substrate for heparin-binding growth factor 1 (acidic fibroblast
growth factor)-activated tyrosine kinase
JOURNAL Mol. Cell. Biol. 10 (9), 4770-4777 (1990)
PUBMED 2167438
COMMENT Original source text: Human umbilical vein endothelial cell line
and brain stem,cDNA to mRNA, clones lambda-PLC5 and lambda 5' PLC
49-9.
Draft entry and computer-readable sequence for [1] kindly submitted
by C.A.Dionne, 30-MAY-1990, for release after publication.
FEATURES Location/Qualifiers
source 1..4408
/db_xref="H-InvDB:HIT000195608"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 77..3949
/note="phospholipase C-gamma"
/codon_start=1
/protein_id="AAA36452.1"
/translation="MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQ
RPERKTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPD
QSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQ
FYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYR
SLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEF
MLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSS
HNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSD
VLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEISADGLP
SPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPH
YFVLTSSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAE
RLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLT
DNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHML
MRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISY
YEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKA
LFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALE
PEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAAD
SQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEKIGT
ERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWI
CGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPC
AISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFH
FQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELAS
LLIKIDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDFRI
SQEHLADHFDSRERRAPRRTRVNGDNRL"
BASE COUNT 1006 a 1253 c 1262 g 887 t
ORIGIN
1 ggggtgccgc cgccgccgtt gcgcttgctc ccgggcggtc ctggcctgtg ccgccgccgc
61 ccccagcgtc ggagccatgg cgggcgccgc gtccccttgc gccaacggct gcgggcccgg
121 cgcgccctcg gacgccgagg tgctgcacct ctgccgcagc ctcgaggtgg gcaccgtcat
181 gactttgttc tactccaaga agtcgcagcg acccgagcgg aagaccttcc aggtcaagct
241 ggagacgcgc cagatcacgt ggagccgggg cgccgacaag atcgaggggg ccattgacat
301 tcgtgaaatt aaggagatcc gcccagggaa gacctcacgg gactttgatc gctatcaaga
361 ggacccagct ttccggccgg accagtcaca ttgctttgtc attctctatg gaatggaatt
421 tcgcctgaaa acgctgagcc tgcaagccac atctgaggat gaagtgaaca tgtggatcaa
481 gggcttaact tggctgatgg aggatacatt gcaggcaccc acacccctgc agattgagag
541 gtggctccgg aagcagtttt actcagtgga tcggaatcgt gaggatcgta tatcagccaa
601 ggacctgaag aacatgctgt cccaggtcaa ctaccgggtc cccaacatgc gcttcctccg
661 agagcggctg acggacctgg agcagcgcag cggggacatc acctacgggc agtttgctca
721 gctgtaccgc agcctcatgt acagcgccca gaagacgatg gacctcccct tcttggaagc
781 cagtactctg agggctgggg agcggccgga gctttgccga gtgtcccttc ctgagttcca
841 gcagttcctt cttgactacc agggggagct gtgggctgtt gatcgcctcc aggtgcagga
901 gttcatgctc agcttcctcc gagacccctt acgagagatc gaggagccat acttcttcct
961 ggatgagttt gtcaccttcc tgttctccaa agagaacagt gtgtggaact cgcagctgga
1021 tgcagtatgc ccggacacca tgaacaaccc tctttcccac tactggatct cctcctcgca
1081 caacacgtac ctgaccgggg accagttctc cagtgagtcc tccttggaag cctatgctcg
1141 ctgcctgcgg atgggctgtc gctgcattga gttggactgc tgggacggcc cggatgggat
1201 gccagttatt taccatgggc acacccttac caccaagatc aagttctcag atgtcctgca
1261 caccatcaag gagcatgcct ttgtggcctc agagtaccca gtcatcctgt ccattgagga
1321 ccactgcagc attgcccagc agagaaacat ggcccaatac ttcaagaagg tgctggggga
1381 cacactcctc accaagcccg tggagatctc tgccgacggg ctcccctcac ccaaccagct
1441 taagaggaag atcctcatca agcacaagaa gctggctgag ggcagtgcct acgaggaggt
1501 gcctacatcc atgatgtact ctgagaacga catcagcaac tctatcaaga atggcatcct
1561 ctacctggag gaccctgtga accacgaatg gtatccccac tactttgttc tgaccagcag
1621 caagatctac tactctgagg agaccagcag tgaccagggc aacgaggatg aggaggagcc
1681 caaggaggtc agcagcagca cagagctgca ctccaatgag aagtggttcc atgggaagct
1741 aggggcaggg cgtgacgggc gtcacatcgc tgagcgcctg cttactgagt actgcatcga
1801 gaccggagcc cctgacggct ccttcctcgt gcgagagagt gagaccttcg tgggcgacta
1861 cacgctctct ttctggcgga acgggaaagt ccagcactgc cgtatccact cccggcaaga
1921 tgctgggacc cccaagttct tcttgacaga caacctcgtc tttgactccc tctatgacct
1981 catcacgcac taccagcagg tgcccctgcg ctgtaatgag tttgagatgc gactttcaga
2041 gcctgtccca cagaccaacg cccacgagag caaagagtgg taccacgcga gcctgaccag
2101 agcacaggct gagcacatgc taatgcgcgt ccctcgtgat ggggccttcc tggtgcggaa
2161 gcggaatgaa cccaactcat atgccatctc tttccgggct gagggcaaga tcaagcattg
2221 ccgtgtccag caagagggcc agacagtgat gctagggaac tcggagttcg acagccttgt
2281 tgacctcatc agctactatg agaaacaccc gctataccgc aagatgaagc tgcgctatcc
2341 catcaacgag gaggcactgg agaagattgg cacagctgag cctgactacg gggccctgta
2401 tgagggacgc aaccctggct tctatgtaga ggcaaaccct atgccaactt tcaagtgtgc
2461 agtcaaagcc ctctttgact acaaggccca gagggaggac gagctgacct tcatcaagag
2521 cgccatcatc cagaatgtgg agaagcaaga gggaggctgg tggcgagggg actacggagg
2581 gaagaagcag ctgtggttcc catcaaacta cgtggaagag atggtcaacc ccgtggccct
2641 ggagccggag agggagcact tggacgagaa cagcccccta ggggacttgc tgcggggggt
2701 cttggatgtg ccggcttgtc agattgccat ccgtcctgag ggcaagaaca accggctctt
2761 cgtcttctcc atcagcatgg cgtcggtggc ccactggtcc ctggatgttg ctgccgactc
2821 acaggaggag ctgcaggact gggtgaaaaa gatccgtgaa gtggcccaga cagcagacgc
2881 caggctcact gaagggaaga taatggaacg gaggaagaag attgccctgg agctctctga
2941 acttgtcgtc tactgccggc ctgttccctt tgatgaagag aagattggca cagaacgtgc
3001 ttgctaccgg gacatgtcat ccttcccgga aaccaaggct gagaaatacg tgaacaaggc
3061 caaaggcaag aagttccttc agtacaatcg actgcagctc tcccgcatct accccaaggg
3121 ccagcgactg gattcctcca actacgatcc tttgcccatg tggatctgtg gcagtcagct
3181 tgtggccctc aacttccaga cccctgacaa gcctatgcag atgaaccagg ccctcttcat
3241 gacgggcagg cactgtggct acgtgctgca gccaagcacc atgcgggatg aggccttcga
3301 cccctttgac aagagcagcc tccgcgggct ggagccatgt gccatctcta ttgaggtgct
3361 gggggcccga catctgccaa agaatggccg aggcattgtg tgtccttttg tggagattga
3421 ggtggctgga gctgagtatg acagcaccaa gcagaagaca gagtttgtgg tggacaatgg
3481 actcaaccct gtatggccag ccaagccctt ccacttccag atcagtaacc ctgaatttgc
3541 ctttctgcgc ttcgtggtgt atgaggaaga catgtttagt gaccagaatt tcctggctca
3601 ggctactttc ccagtaaaag gcctgaagac aggatacaga gcagtgcctt tgaagaacaa
3661 ctacagtgag gacctggagt tggcctccct gctgatcaag attgacattt tccctgccaa
3721 ggagaatggt gacctcagtc ccttcagtgg tacgtccctg cgggagcggg gctcagatgc
3781 ctcaggccag ctgtttcatg gccgagcccg ggaaggctcc tttgaatccc gctaccagca
3841 gccgtttgag gacttccgca tctcccagga gcatctcgca gaccattttg acagtcgaga
3901 acgaagggcc ccaagaagga ctcgggtcaa tggagacaac cgcctctagt tgtaccccag
3961 cctcgttgga gagcagcagg tgctgtgcgc cttgtagaat gccgcgaact gggttctttg
4021 gaagcagccc cctgtggcgg ccttccgggt ctcgcagcct gaagcctgga ttccagcagt
4081 gaatgctaga cagaaaccaa gccattaatg agatgttatt actgttttgg gcctccatgc
4141 cccagctctg gatgaaggca aaaactgtac tgtgtttcgc attaagcaca cacatctggc
4201 cctgacttct ggagatggat ccttccatct tgtggggcca ggaccatggc cgaagcccct
4261 tggagagaga ggctgcctca gccagtggca caggagactc caaggagcta ctgacattcc
4321 taagagtgga ggaggaggag gagccttgct gggccaggga aacaaagttt acattgtcct
4381 gtagctttaa aaccacagct gggcaggg
//