LOCUS HUMHER3A 4975 bp mRNA linear HUM 11-JUN-1993
DEFINITION Human epidermal growth factor receptor (HER3) mRNA, complete cds.
ACCESSION M34309
VERSION M34309.1
KEYWORDS HER3 gene; epidermal growth factor receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4975)
AUTHORS Plowman,G.D., Whitney,G.S., Neubauer,M.G., Green,J.M.,
McDonald,V.L., Todaro,G.J. and Shoyab,M.
TITLE Molecular cloning and expression of an additional epidermal growth
factor receptor-related gene
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (13), 4905-4909 (1990)
PUBMED 2164210
COMMENT Original source text: Human cell line MDA-MB-361, cDNA to mRNA.
Draft entry and computer-readable sequence for [1] kindly submitted
by G.D.Plowman, 16-MAY-1990, for release after publication.
FEATURES Location/Qualifiers
source 1..4975
/db_xref="H-InvDB:HIT000195575"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 199..4227
/note="HER3 protein precursor"
/codon_start=1
/protein_id="AAA35979.1"
/translation="MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAEN
QYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNL
RVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDT
IDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHC
FGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNP
HTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGT
GSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVRE
ITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEIS
AGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGG
CWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMGGTATCN
GSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGP
ELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLE
RGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVC
IKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDH
VRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVA
DLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAG
LRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDP
PRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSA
LSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGGSCQESAVSGSSERCPRPVSLHPMP
RGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPL
SPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRR
RHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEY
MNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATD
SAFDNPDYWHSRLFPKANAQRT"
sig_peptide 199..255
/note="HER3 signal peptide"
mat_peptide 256..4224
/product="HER3 protein"
BASE COUNT 1195 a 1309 c 1327 g 1144 t
ORIGIN Chromosome 12q13.
1 ctctcacaca cacacacccc tcccctgcca tccctccccg gactccggct ccggctccga
61 ttgcaatttg caacctccgc tgccgtcgcc gcagcagcca ccaattcgcc agcggttcag
121 gtggctcttg cctcgatgtc ctagcctagg ggcccccggg ccggacttgg ctgggctccc
181 ttcaccctct gcggagtcat gagggcgaac gacgctctgc aggtgctggg cttgcttttc
241 agcctggccc ggggctccga ggtgggcaac tctcaggcag tgtgtcctgg gactctgaat
301 ggcctgagtg tgaccggcga tgctgagaac caataccaga cactgtacaa gctctacgag
361 aggtgtgagg tggtgatggg gaaccttgag attgtgctca cgggacacaa tgccgacctc
421 tccttcctgc agtggattcg agaagtgaca ggctatgtcc tcgtggccat gaatgaattc
481 tctactctac cattgcccaa cctccgcgtg gtgcgaggga cccaggtcta cgatgggaag
541 tttgccatct tcgtcatgtt gaactataac accaactcca gccacgctct gcgccagctc
601 cgcttgactc agctcaccga gattctgtca gggggtgttt atattgagaa gaacgataag
661 ctttgtcaca tggacacaat tgactggagg gacatcgtga gggaccgaga tgctgagata
721 gtggtgaagg acaatggcag aagctgtccc ccctgtcatg aggtttgcaa ggggcgatgc
781 tggggtcctg gatcagaaga ctgccagaca ttgaccaaga ccatctgtgc tcctcagtgt
841 aatggtcact gctttgggcc caaccccaac cagtgctgcc atgatgagtg tgccgggggc
901 tgctcaggcc ctcaggacac agactgcttt gcctgccggc acttcaatga cagtggagcc
961 tgtgtacctc gctgtccaca gcctcttgtc tacaacaagc taactttcca gctggaaccc
1021 aatccccaca ccaagtatca gtatggagga gtttgtgtag ccagctgtcc ccataacttt
1081 gtggtggatc aaacatcctg tgtcagggcc tgtcctcctg acaagatgga agtagataaa
1141 aatgggctca agatgtgtga gccttgtggg ggactatgtc ccaaagcctg tgagggaaca
1201 ggctctggga gccgcttcca gactgtggac tcgagcaaca ttgatggatt tgtgaactgc
1261 accaagatcc tgggcaacct ggactttctg atcaccggcc tcaatggaga cccctggcac
1321 aagatccctg ccctggaccc agagaagctc aatgtcttcc ggacagtacg ggagatcaca
1381 ggttacctga acatccagtc ctggccgccc cacatgcaca acttcagtgt tttttccaat
1441 ttgacaacca ttggaggcag aagcctctac aaccggggct tctcattgtt gatcatgaag
1501 aacttgaatg tcacatctct gggcttccga tccctgaagg aaattagtgc tgggcgtatc
1561 tatataagtg ccaataggca gctctgctac caccactctt tgaactggac caaggtgctt
1621 cgggggccta cggaagagcg actagacatc aagcataatc ggccgcgcag agactgcgtg
1681 gcagagggca aagtgtgtga cccactgtgc tcctctgggg gatgctgggg cccaggccct
1741 ggtcagtgct tgtcctgtcg aaattatagc cgaggaggtg tctgtgtgac ccactgcaac
1801 tttctgaatg gggagcctcg agaatttgcc catgaggccg aatgcttctc ctgccacccg
1861 gaatgccaac ccatgggggg cactgccaca tgcaatggct cgggctctga tacttgtgct
1921 caatgtgccc attttcgaga tgggccccac tgtgtgagca gctgccccca tggagtccta
1981 ggtgccaagg gcccaatcta caagtaccca gatgttcaga atgaatgtcg gccctgccat
2041 gagaactgca cccaggggtg taaaggacca gagcttcaag actgtttagg acaaacactg
2101 gtgctgatcg gcaaaaccca tctgacaatg gctttgacag tgatagcagg attggtagtg
2161 attttcatga tgctgggcgg cacttttctc tactggcgtg ggcgccggat tcagaataaa
2221 agggctatga ggcgatactt ggaacggggt gagagcatag agcctctgga ccccagtgag
2281 aaggctaaca aagtcttggc cagaatcttc aaagagacag agctaaggaa gcttaaagtg
2341 cttggctcgg gtgtctttgg aactgtgcac aaaggagtgt ggatccctga gggtgaatca
2401 atcaagattc cagtctgcat taaagtcatt gaggacaaga gtggacggca gagttttcaa
2461 gctgtgacag atcatatgct ggccattggc agcctggacc atgcccacat tgtaaggctg
2521 ctgggactat gcccagggtc atctctgcag cttgtcactc aatatttgcc tctgggttct
2581 ctgctggatc atgtgagaca acaccggggg gcactggggc cacagctgct gctcaactgg
2641 ggagtacaaa ttgccaaggg aatgtactac cttgaggaac atggtatggt gcatagaaac
2701 ctggctgccc gaaacgtgct actcaagtca cccagtcagg ttcaggtggc agattttggt
2761 gtggctgacc tgctgcctcc tgatgataag cagctgctat acagtgaggc caagactcca
2821 attaagtgga tggcccttga gagtatccac tttgggaaat acacacacca gagtgatgtc
2881 tggagctatg gtgtgacagt ttgggagttg atgaccttcg gggcagagcc ctatgcaggg
2941 ctacgattgg ctgaagtacc agacctgcta gagaaggggg agcggttggc acagccccag
3001 atctgcacaa ttgatgtcta catggtgatg gtcaagtgtt ggatgattga tgagaacatt
3061 cgcccaacct ttaaagaact agccaatgag ttcaccagga tggcccgaga cccaccacgg
3121 tatctggtca taaagagaga gagtgggcct ggaatagccc ctgggccaga gccccatggt
3181 ctgacaaaca agaagctaga ggaagtagag ctggagccag aactagacct agacctagac
3241 ttggaagcag aggaggacaa cctggcaacc accacactgg gctccgccct cagcctacca
3301 gttggaacac ttaatcggcc acgtgggagc cagagccttt taagtccatc atctggatac
3361 atgcccatga accagggtaa tcttgggggg tcttgccagg agtctgcagt ttctgggagc
3421 agtgaacggt gcccccgtcc agtctctcta cacccaatgc cacggggatg cctggcatca
3481 gagtcatcag aggggcatgt aacaggctct gaggctgagc tccaggagaa agtgtcaatg
3541 tgtagaagcc ggagcaggag ccggagccca cggccacgcg gagatagcgc ctaccattcc
3601 cagcgccaca gtctgctgac tcctgttacc ccactctccc cacccgggtt agaggaagag
3661 gatgtcaacg gttatgtcat gccagataca cacctcaaag gtactccctc ctcccgggaa
3721 ggcacccttt cttcagtggg tctcagttct gtcctgggta ctgaagaaga agatgaagat
3781 gaggagtatg aatacatgaa ccggaggaga aggcacagtc cacctcatcc ccctaggcca
3841 agttcccttg aggagctggg ttatgagtac atggatgtgg ggtcagacct cagtgcctct
3901 ctgggcagca cacagagttg cccactccac cctgtaccca tcatgcccac tgcaggcaca
3961 actccagatg aagactatga atatatgaat cggcaacgag atggaggtgg tcctgggggt
4021 gattatgcag ccatgggggc ctgcccagca tctgagcaag ggtatgaaga gatgagagct
4081 tttcaggggc ctggacatca ggccccccat gtccattatg cccgcctaaa aactctacgt
4141 agcttagagg ctacagactc tgcctttgat aaccctgatt actggcatag caggcttttc
4201 cccaaggcta atgcccagag aacgtaactc ctgctccctg tggcactcag ggagcattta
4261 atggcagcta gtgcctttag agggtaccgt cttctcccta ttccctctct ctcccaggtc
4321 ccagcccctt ttccccagtc ccagacaatt ccattcaatc tttggaggct tttaaacatt
4381 ttgacacaaa attcttatgg tatgtagcca gctgtgcact ttcttctctt tcccaacccc
4441 aggaaaggtt ttccttattt tgtgtgcttt cccagtccca ttcctcagct tcttcacagg
4501 cactcctgga gatatgaagg attactctcc atatcccttc ctctcaggct cttgactact
4561 tggaactagg ctcttatgtg tgcctttgtt tcccatcaga ctgtcaagaa gaggaaaggg
4621 aggaaaccta gcagaggaaa gtgtaatttt ggtttatgac tcttaacccc ctagaaagac
4681 agaagcttaa aatctgtgaa gaaagaggtt aggagtagat attgattact atcataattc
4741 agcacttaac tatgagccag gcatcatact aaacttcacc tacattatct cacttagtcc
4801 tttatcatcc ttaaaacaat tctgtgacat acatattatc tcattttaca caaagggaag
4861 tcgggcatgg tggctcatgc ctgtaatctc agcactttgg gaggctgagg cagaaggatt
4921 acctgaggca aggagtttga gaccagctta gccaacatag taagaccccc atctc
//