LOCUS HUMADRA2RA 2072 bp DNA linear HUM 30-OCT-1994
DEFINITION Human alpha-2-adrenergic receptor (alpha-2 c2) gene, complete cds.
ACCESSION M34041
VERSION M34041.1
KEYWORDS alpha-2-adrenergic receptor; plasma membrane protein;
receptor-coupled G protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2072)
AUTHORS Lomasney,J.W., Lorenz,W., Allen,L.F., King,K., Regan,J.W.,
Yang-Feng,T.L., Caron,M.G. and Lefkowitz,R.J.
TITLE Expansion of the alpha 2-adrenergic receptor family: cloning and
characterization of a human alpha 2-adrenergic receptor subtype,
the gene for which is located on chromosome 2
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (13), 5094-5098 (1990)
PUBMED 2164221
COMMENT Original source text: Human placenta DNA, clone alpha-2 C2.
Draft entry and computer-readable sequence for [1] kindly submitted
by J.W.Lomasney, 03-MAY-1990, for release after publication.
FEATURES Location/Qualifiers
source 1..2072
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="2"
gene 413..1765
/gene="ADRA2B"
CDS 413..1765
/gene="ADRA2B"
/note="alpha-2-adrenergic receptor (alpha-2 C2) old gene
name 'ADRA2RL1'"
/codon_start=1
/protein_id="AAA51666.1"
/db_xref="GDB:G00-120-539"
/translation="MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLR
APQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVH
LCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRG
RPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGES
KQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAA
LPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSR
VLATLRGQVLLGRGVGAIGGQWWRRRAHVTREKRFTFVLAVVIGVFVLCWFPFFFSYS
LGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW
"
BASE COUNT 316 a 705 c 660 g 391 t
ORIGIN Chromosome 2.
1 ctgcaggcgc ggctggggcg aaacgtgcga gctgagcggg cgcaaggtcc tccgcgcctc
61 ctttaagaac cggcccagcc cggcccgcgc ccccagagcg tacggcatcc gcgtggcgga
121 gggcgcgact ttctccggtc ccgggcggga cggggacggc ggcgggacaa cttgggaaac
181 ttctctgggg cggacggcag ggaccccggg caccgtggag gaggatgtag gagggcggct
241 gctggtcctg ggtgttcccg acctcctagg ccccgctcgt ccaggccatg gggctccagc
301 gccctcgcgg cgccggaggg gcgacgctct tgtctagccg agccgggcag cgctgtcgtc
361 cacggtgcgc actgggcggg cagcgctccc tctgcccacc tcccgccccg tcatggacca
421 ccaggacccc tactccgtgc aggccacagc ggccatagcg gcggccatca ccttcctcat
481 tctctttacc atcttcggca acgctctggt catcctggct gtgttgacca gccgctcgct
541 gcgcgcccct cagaacctgt tcctggtgtc gctggccgcc gccgacatcc tggtggccac
601 gctcatcatc cctttctcgc tggccaacga gctgctgggc tactggtact tccggcgcac
661 gtggtgcgag gtgtacctgg cgctcgacgt gctcttctgc acctcgtcca tcgtgcacct
721 gtgcgccatc agcctggacc gctactgggc cgtgagccgc gcgctggagt acaactccaa
781 gcgcaccccg cgccgcatca agtgcatcat cctcactgtg tggctcatcg ccgccgtcat
841 ctcgctgccg cccctcatct acaagggcga ccagggcccc cagccgcgcg ggcgccccca
901 gtgcaagctc aaccaggagg cctggtacat cctggcctcc agcatcggat ctttctttgc
961 tccttgcctc atcatgatcc ttgtctacct gcgcatctac ctgatcgcca aacgcagcaa
1021 ccgcagaggt cccagggcca agggggggcc tgggcagggt gagtccaagc agccccgacc
1081 cgaccatggt ggggctttgg cctcagccaa actgccagcc ctggcctctg tggcttctgc
1141 cagagaggtc aacggacact cgaagtccac tggggagaag gaggaggggg agacccctga
1201 agatactggg acccgggcct tgccacccag ttgggctgcc cttcccaact caggccaggg
1261 ccagaaggag ggtgtttgtg gggcatctcc agaggatgaa gctgaagagg aggaagagga
1321 ggaggaggag gaggaagagt gtgaacccca ggcagtgcca gtgtctccgg cctcagcttg
1381 cagccccccg ctgcagcagc cacagggctc ccgggtgctg gccaccctac gtggccaggt
1441 gctcctgggc aggggcgtgg gtgctatagg tgggcagtgg tggcgtcgaa gggcgcacgt
1501 gacccgggag aagcgcttca ccttcgtgct ggctgtggtc attggcgttt ttgtgctctg
1561 ctggttcccc ttcttcttca gctacagcct gggcgccatc tgcccgaagc actgcaaggt
1621 gccccatggc ctcttccagt tcttcttctg gatcggctac tgcaacagct cactgaaccc
1681 tgttatctac accatcttca accaggactt ccgccgtgcc ttccggagga tcctgtgccg
1741 cccgtggacc cagacggcct ggtgagcccg cctgcgctgc ccctgtgggt tggtgcggtg
1801 gcgccggggt caccctgctt cttgccctgc tgtgtgtggc tgcctcccct gggctttctg
1861 ctccctgccc agatcctgta ggcctcatct taggaacccc ttgggagggg tgggcagggg
1921 ggctgctagc aagggtccca gtgaagcttc cccttgccgg cttagctgtg ggggacccct
1981 tctccaccct ctccctgagc acaggccgat ggaggtggtt caaatcctct ggaacatagc
2041 caagaccagg agaagagaga gcactttctt cc
//