LOCUS HUMCPIIA3A 1748 bp mRNA linear HUM 01-NOV-1994
DEFINITION Human cytochrome P450IIA3 (CYP2A3) mRNA, complete cds.
ACCESSION M33318 M33316
VERSION M33318.1
KEYWORDS coumarin 7-hydroxylase; cytochrome P450; cytochrome P450 IIA3.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1748)
AUTHORS Yamano,S., Tatsuno,J. and Gonzalez,F.J.
TITLE The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human
liver microsomes
JOURNAL Biochemistry 29 (5), 1322-1329 (1990)
PUBMED 2322567
COMMENT Original source text: Human liver DNA.
FEATURES Location/Qualifiers
source 1..1748
/db_xref="H-InvDB:HIT000195506"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="19q13.2"
gene 1..1748
/gene="CYP2A"
mRNA <1..1748
/gene="CYP2A"
/product="CYPIIA3 mRNA"
CDS 10..1494
/gene="CYP2A"
/note="cytochrome P450IIA3"
/codon_start=1
/protein_id="AAA52067.1"
/db_xref="GDB:G00-120-607"
/translation="MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIG
NYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRG
EQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDAL
RGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQ
LYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQ
EEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRV
IGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVY
PMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELF
LFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR"
variation 60
/gene="CYP2A"
/note="g in allele CYP2A3; a in allele CYP2A3v"
variation 488
/gene="CYP2A"
/note="t in allele CYP2A3; a in allele CYP2A3v"
variation 1645
/gene="CYP2A"
/note="g in allele CYP2A3; c in allele CYP2A3v"
BASE COUNT 395 a 478 c 516 g 359 t
ORIGIN
1 gctaccacca tgctggcctc agggatgctt ctggtggcct tgctggtctg cctgactgtg
61 atggtcttga tgtctgtttg gcagcagagg aagagcaagg ggaagctgcc tccgggaccc
121 accccattgc ccttcattgg aaactacctg cagctgaaca cagagcagat gtacaactcc
181 ctcatgaaga tcagtgagcg ctatggcccc gtgttcacca ttcacttggg gccccggcgg
241 gtcgtggtgc tgtgtggaca tgatgccgtc agggaggctc tggtggacca ggctgaggag
301 ttcagcgggc gaggcgagca agccaccttc gactgggtct tcaaaggcta tggcgtggta
361 ttcagcaacg gggagcgcgc caagcagctc cggcgcttct ccatcgccac cctgcgggac
421 ttcggggtgg gcaagcgagg catcgaggag cgcatccagg aggaggcggg cttcctcatc
481 gacgccctcc ggggcactgg cggcgccaat atcgatccca ccttcttcct gagccgcaca
541 gtctccaatg tcatcagctc cattgtcttt ggggaccgct ttgactataa ggacaaagag
601 ttcctgtcac tgttgcgcat gatgctagga atcttccagt tcacgtcaac ctccacgggg
661 cagctctatg agatgttctc ttcggtgatg aaacacctgc caggaccaca gcaacaggcc
721 tttcagttgc tgcaagggct ggaggacttc atagccaaga aggtggagca caaccagcgc
781 acgctggatc ccaattcccc acgggacttc attgactcct ttctcatccg catgcaggag
841 gaggagaaga accccaacac ggagttctac ttgaaaaacc tggtgatgac cacgttgaac
901 ctcttcattg ggggcaccga gaccgtcagc accaccctgc gctatggctt cttgctgctc
961 atgaagcacc cagaggtgga ggccaaggtc catgaggaga ttgacagagt gatcggcaag
1021 aaccggcagc ccaagtttga ggaccgggcc aagatgccct acatggaggc agtgatccac
1081 gagatccaaa gatttggaga cgtgatcccc atgagtttgg cccgcagagt caaaaaggac
1141 accaagtttc gggatttctt cctccctaag ggcaccgaag tgtaccctat gctgggctct
1201 gtgctgagag accccagttt cttctccaac ccccaggact tcaatcccca gcacttcctg
1261 aatgagaagg ggcagtttaa gaagagtgat gcttttgtgc ccttttccat cggaaagcgg
1321 aactgtttcg gagaaggcct ggccagaatg gagctctttc tcttcttcac caccgtcatg
1381 cagaacttcc gcctcaagtc ctcccagtca cctaaggaca ttgacgtgtc ccccaaacac
1441 gtgggctttg ccacgatccc acgaaactac accatgagct tcctgccccg ctgagcgagg
1501 gctgtgccgg tgcaggtctg gtgggcgggg ccagggaaag ggcagggcca agaccgggct
1561 tgggagaggg gcgcagctaa gactgggggc aggatggcgg aaaggaaggg gcgtggtggc
1621 tagagggaag agaagaaaca gaaggggctc agttcacctt gataaggtgc ttccgagctg
1681 ggatgagagg aaggaaaccc ttacattatg ctatgaagag tagtaataat agcagctctt
1741 atttcctg
//