LOCUS HUMCYIIA4A 1747 bp mRNA linear HUM 02-NOV-1994
DEFINITION Human cytochrome P450IIA4 (CYP2A4) mRNA, complete cds.
ACCESSION M33317
VERSION M33317.1
KEYWORDS cytochrome P450; cytochrome P450 IIA4.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1747)
AUTHORS Yamano,S., Tatsuno,J. and Gonzalez,F.J.
TITLE The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human
liver microsomes
JOURNAL Biochemistry 29 (5), 1322-1329 (1990)
PUBMED 2322567
COMMENT Original source text: Human liver DNA.
FEATURES Location/Qualifiers
source 1..1747
/db_xref="H-InvDB:HIT000195505"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="19q13.2"
gene 1..1747
/gene="CYP2A"
mRNA <1..1747
/gene="CYP2A"
/product="CYP2A4 mRNA"
CDS 10..1494
/gene="CYP2A"
/note="cytochrome P450IIA4"
/codon_start=1
/protein_id="AAA52138.1"
/db_xref="GDB:G00-120-607"
/translation="MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIG
NYLQLNTEHICDSIMKFSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRG
EQATFDWVFKGYGVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAI
RSSHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQ
LYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQ
EEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRV
IGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVF
PMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRYCFGEGLARMELF
LFFTTVMQNFRLKSSQSPKDIDVSSKHVGFATIPRNYTMSFLPR"
BASE COUNT 396 a 471 c 517 g 363 t
ORIGIN
1 gctaccacca tgctggcctc agggctgctt ctggtggcct tgctggcctg cctgactgtg
61 atggtcttga tgtctgtctg gcagcagagg aagagcaggg ggaagctgcc tccgggaccc
121 accccactgc ccttcattgg aaactacctc cagctgaaca cagagcacat atgtgactcc
181 atcatgaagt tcagtgagtg ctatggcccc gtgttcacca ttcacttggg gccccggcgg
241 gtcgtggtgc tgtgtggaca tgatgccgtc agggaggctc tggtggacca ggctgaggag
301 ttcagcgggc gaggcgagca agccaccttc gactgggtct tcaaaggcta tggcgtggcg
361 ttcagcaacg gggagcgcgc caagcagctc ctgcgctttg ccatcgccac cctgagggac
421 ttcggggtgg gcaagcgagg catcgaggag cgcatccagg aggagtcggg cttcctcatc
481 gaggccatcc ggagcagcca cggcgccaat atcgatccca ccttcttcct gagccgcaca
541 gtctccaatg tcatcagctc cattgtcttt ggggaccgct ttgactatga ggacaaagag
601 ttcctgtcac tgctgagcat gatgctagga atcttccagt tcacgtcaac ctccacgggg
661 cagctctatg agatgttctc ttcggtgatg aaacacctgc caggaccaca gcaacaggcc
721 tttaagttgc tgcaagggct ggaggacttc atagccaaga aggtggagca caaccagcgc
781 acgctggatc ccaattcccc acaggacttc atcgactcct ttctcatcca catgcaggag
841 gaggagaaga accccaacac ggagttctac ttgaagaacc tgatgatgag cacgttgaac
901 ctcttcattg caggcacgga gaccgtcagc accaccctgc gctatggctt cttgctgctc
961 atgaagcacc cagaggtgga ggccaaggtc catgaggaga ttgacagagt gatcggcaag
1021 aaccggcagc ccaagtttga ggaccggacc aagatgccct acatggaggc agtgatccac
1081 gagatccaaa gatttggaga cgtgatcccc atgagtttgg cccgcagagt caaaaaggac
1141 accaagtttc gggatttttt cctccctaag ggcaccgaag tgttccctat gctgggctcc
1201 gtgctgagag accccagttt cttctccaac ccccaggact tcaatcccca gcacttcctg
1261 gatgacaagg ggcagtttaa gaagagtgat gcttttgtgc ccttttccat cggaaagcgg
1321 tactgtttcg gagaaggcct ggccagaatg gagctctttc tcttcttcac caccgtcatg
1381 cagaacttcc gcctcaagtc ctcccagtca cctaaggaca ttgacgtgtc ctccaaacac
1441 gtgggctttg ccacgatccc acgaaactac accatgagct tcctgccccg ctgagcgagg
1501 gctgtgccgg tgcaggtctg gtgggcgggg ccagggaaag gcggggtcag ggcggggttc
1561 gcggaagagg cgggtataag aatgggggga agatgcggga aaggaagggg cgtggtggct
1621 agagggaaga gaagaaacag aaggggctca gttcaccttg ataaggtgct tccgtggtgg
1681 gatgagagga agggaaacct tacattatgc tatgaagagt agtaataata gcagctctta
1741 tttcctg
//