LOCUS HUMPPOL 3660 bp mRNA linear HUM 08-JAN-1995
DEFINITION Human poly(ADP-ribose) polymerase mRNA, complete cds.
ACCESSION M32721 J03030
VERSION M32721.1
KEYWORDS nuclear enzyme; poly (ADP-ribose) polymerase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3660)
AUTHORS Cherney,B.W., McBride,O.W., Chen,D.F., Alkhatib,H., Bhatia,K.,
Hensley,P. and Smulson,M.E.
TITLE cDNA sequence, protein structure, and chromosomal location of the
human gene for poly(ADP-ribose) polymerase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 84 (23), 8370-8374 (1987)
PUBMED 2891139
COMMENT Original source text: Human, cDNA to mRNA, (library of Okayama and
Berg).
FEATURES Location/Qualifiers
source 1..3660
/db_xref="H-InvDB:HIT000195479"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="1q41-q42"
gene 1..3660
/gene="PPOL"
mRNA <1..3660
/gene="PPOL"
/note="poly(ADP-ribose) polymerase"
CDS 160..3204
/gene="PPOL"
/note="poly(ADP-ribose) polymerase"
/codon_start=1
/protein_id="AAA60155.1"
/db_xref="GDB:G00-119-508"
/translation="MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMF
DGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGI
GSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHP
GCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDE
VAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGE
SAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWV
TPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSN
MKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEAN
IRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSK
GQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGT
NSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEQFMKLYEEKTGN
AWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESM
KKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLI
PHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLK
TDIKVVDRDSEEAEIIRKYVKNTHATTHSAYDLEVIDIFKIEREGECQRYKPFKQLHN
RRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYYHTSQGD
PIGLILLGEVALGNMYELKHASHISRLPKGKHSVKGLGKTTPDPSANISLDGVDVPLG
TGISSGVIDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW"
BASE COUNT 999 a 832 c 1028 g 801 t
ORIGIN
1 aatctatcag ggaacggcgg tggccggtgc ggcgtgttcg gtgcgctctg gccgctcagg
61 ccgtgcggct gggtgagcgc acgcgaggcg gcgaggcggc aagcgtgttt ctaggtcgtg
121 gcgtcgggct tccggagctt tggcggcagc taggggagga tggcggagtc ttcggataag
181 ctctatcgag tcgagtacgc caagagcggg cgcgcctctt gcaagaaatg cagcgagagc
241 atccccaagg actcgctccg gatggccatc atggtgcagt cgcccatgtt tgatggaaaa
301 gtcccacact ggtaccactt ctcctgcttc tggaaggtgg gccactccat ccggcaccct
361 gacgttgagg tggatgggtt ctctgagctt cggtgggatg accagcagaa agtcaagaag
421 acagcggaag ctggaggagt gacaggcaaa ggccaggatg gaattggtag caaggcagag
481 aagactctgg gtgactttgc agcagagtat gccaagtcca acagaagtac gtgcaagggg
541 tgtatggaga agatagaaaa gggccaggtg cgcctgtcca agaagatggt ggacccggag
601 aagccacagc taggcatgat tgaccgctgg taccatccag gctgctttgt caagaacagg
661 gaggagctgg gtttccggcc cgagtacagt gcgagtcagc tcaagggctt cagcctcctt
721 gctacagagg ataaagaagc cctgaagaag cagctcccag gagtcaagag tgaaggaaag
781 agaaaaggcg atgaggtgga tggagtggat gaagtggcga agaagaaatc taaaaaagaa
841 aaagacaagg atagtaagct tgaaaaagcc ctaaaggctc agaacgacct gatctggaac
901 atcaaggacg agctaaagaa agtgtgttca actaatgacc tgaaggagct actcatcttc
961 aacaagcagc aagtgccttc tggggagtcg gcgatcttgg accgagtagc tgatggcatg
1021 gtgttcggtg ccctccttcc ctgcgaggaa tgctcgggtc agctggtctt caagagcgat
1081 gcctattact gcactgggga cgtcactgcc tggaccaagt gtatggtcaa gacacagaca
1141 cccaaccgga aggagtgggt aaccccaaag gaattccgag aaatctctta cctcaagaaa
1201 ttgaaggtta aaaagcagga ccgtatattc cccccagaaa ccagcgcctc cgtggcggcc
1261 acgcctccgc cctccacagc ctcggctcct gctgctgtga actcctctgc ttcagcagat
1321 aagccattat ccaacatgaa gatcctgact ctcgggaagc tgtcccggaa caaggatgaa
1381 gtgaaggcca tgattgagaa actcgggggg aagttgacgg ggacggccaa caaggcttcc
1441 ctgtgcatca gcaccaaaaa ggaggtggaa aagatgaata agaagatgga ggaagtaaag
1501 gaagccaaca tccgagttgt gtctgaggac ttcctccagg acgtctccgc ctccaccaag
1561 agccttcagg agttgttctt agcgcacatc ttgtcccctt ggggggcaga ggtgaaggca
1621 gagcctgttg aagttgtggc cccaagaggg aagtcagggg ctgcgctctc caaaaaaagc
1681 aagggccagg tcaaggagga aggtatcaac aaatctgaaa agagaatgaa attaactctt
1741 aaaggaggag cagctgtgga tcctgattct ggactggaac actctgcgca tgtcctggag
1801 aaaggtggga aggtcttcag tgccaccctt ggcctggtgg acatcgttaa aggaaccaac
1861 tcctactaca agctgcagct tctggaggac gacaaggaaa acaggtattg gatattcagg
1921 tcctggggcc gtgtgggtac ggtgatcggt agcaacaaac tggaacagat gccgtccaag
1981 gaggatgcca ttgagcagtt catgaaatta tatgaagaaa aaaccgggaa cgcttggcac
2041 tccaaaaatt tcacgaagta tcccaaaaag ttttaccccc tggagattga ctatggccag
2101 gatgaagagg cagtgaagaa gctcacagta aatcctggca ccaagtccaa gctccccaag
2161 ccagttcagg acctcatcaa gatgatcttt gatgtggaaa gtatgaagaa agccatggtg
2221 gagtatgaga tcgaccttca gaagatgccc ttggggaagc tgagcaaaag gcagatccag
2281 gccgcatact ccatcctcag tgaggtccag caggcggtgt ctcagggcag cagcgactct
2341 cagatcctgg atctctcaaa tcgcttttac accctgatcc cccacgactt tgggatgaag
2401 aagcctccgc tcctgaacaa tgcagacagt gtgcaggcca aggtggaaat gcttgacaac
2461 ctgctggaca tcgaggtggc ctacagtctg ctcaggggag ggtctgatga tagcagcaag
2521 gatcccatcg atgtcaacta tgagaagctc aaaactgaca ttaaggtggt tgacagagat
2581 tctgaagaag ccgagatcat caggaagtat gttaagaaca ctcatgcaac cacacacagt
2641 gcgtatgact tggaagtcat cgatatcttt aagatagagc gtgaaggcga atgccagcgt
2701 tacaagccct ttaagcagct tcataaccga agattgctgt ggcacgggtc caggaccacc
2761 aactttgctg ggatcctgtc ccagggtctt cggatagccc cgcctgaagc gcccgtgaca
2821 ggctacatgt ttggtaaagg gatctatttc gctgacatgg tctccaagag tgccaactac
2881 taccatacgt ctcagggaga cccaataggc ttaatcctgt tgggagaagt tgcccttgga
2941 aacatgtatg aactgaagca cgcttcacat atcagcaggt tacccaaggg caagcacagt
3001 gtcaaaggtt tgggcaaaac tacccctgat ccttcagcta acattagtct ggatggtgta
3061 gacgttcctc ttgggaccgg gatttcatct ggtgtgatag acacctctct actatataac
3121 gagtacattg tctatgatat tgctcaggta aatctgaagt atctgctgaa actgaaattc
3181 aattttaaga cctccctgtg gtaattggga gaggtagccg agtcacaccc ggtggctgtg
3241 gtatgaattc acccgaagcg cttctgcacc aactcacctg gccgctaagt tgctgatggg
3301 tagtacctgt actaaaccac ctcagaaagg attttacaga aacgtgttaa aggttttctc
3361 taacttctca agtcccttgt tttgtgttgt gtctgtgggg aggggttgtt ttggggttgt
3421 ttttgttttt tcttgccagg tagataaaac tgacatagag aaaaggctgg agagagattc
3481 tgttgcatag actagtccta tggaaaaaac caaagcttcg ttagaatgtc tgccttactg
3541 gtttccccag ggaaggaaaa atacacttcc accctttttt ctaagtgttc gtctttagtt
3601 ttgattttgg aaagatgtta agcatttatt tttagttaaa ataaaaacta atttcatact
//