LOCUS HUMARSBX 2802 bp mRNA linear HUM 31-OCT-1994
DEFINITION Human arylsulfatase B (ASB) mRNA, complete cds.
ACCESSION M32373
VERSION M32373.1
KEYWORDS arylsulfatase; lysosomal hydrolase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2802)
AUTHORS Schuchman,E.H., Jackson,C.E. and Desnick,R.J.
TITLE Human arylsulfatase B: MOPAC cloning, nucleotide sequence of a
full-length cDNA, and regions of amino acid identity with
arylsulfatases A and C
JOURNAL Genomics 6 (1), 149-158 (1990)
PUBMED 1968043
COMMENT Original source text: Human liver, cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..2802
/db_xref="H-InvDB:HIT000195474"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="5p11-q13"
gene 1..2802
/gene="ARSB"
mRNA <1..2802
/gene="ARSB"
/product="ASB mRNA"
CDS 560..2161
/gene="ARSB"
/note="arylsulfatase B precursor"
/codon_start=1
/protein_id="AAA51779.1"
/db_xref="GDB:G00-119-008"
/translation="MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRP
PHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGR
YQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRR
GFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKR
AIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEA
VGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVAS
PLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDMWKTISEGSPSPRIELL
HNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGNWKLLTGYPGCGYW
FPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRLQFYHKH
SVPVYFPAQDPRCDPKATGVWGPWM"
sig_peptide 560..679
/gene="ARSB"
/note="arylsulfatase B signal peptide"
mat_peptide 680..2158
/gene="ARSB"
/product="arylsulfatase B"
BASE COUNT 646 a 767 c 726 g 663 t
ORIGIN
1 catggatttc gacattgctg gacctgccac aggctgggct cttgtgctag aaatgacttg
61 ctagctagac atcatggttc aggatctgag tcagaggttt aaccatttat aagctttttt
121 cttatgaaaa attggcacta attataatgt ctaactgtca gagttgttgc aggctttaca
181 ggagacgcgg gctgtgaaga tgctttgtaa attgtgaagc gttattaaag aacacatctt
241 tttttttagg aaaccacggt gcaaatttaa ttgccgggga agataacggg ccttggtgcc
301 ctccaagcgt cagctgagtt tccaagaagc cgggcagcgg gcgcccgcgg gttcgtctct
361 ggctcctcct ccgccacagc agccgggggc ccgggtcgga ggcggcgggg gccgagcgcc
421 cggcctcgca agcccacggc ccgctggggg tgccgtcccg cgccggggcg gagcaggccc
481 cggcagccca gttcctcatt ctatcagcgg tacaaggggc tggtggcgcc acaggcgctg
541 ggaccgcggg cggacaagga tgggtccgcg cggcgcggcg agcttgcccc gaggccccgg
601 acctcggcgg ctgctcctcc ccgtcgtcct cccgctgctg ctgctgctgt tgttggcgcc
661 gccgggctcg ggcgccgggg ccagccggcc gccccacctg gtcttcttgc tggcagacga
721 cctaggctgg aacgacgtcg gcttccacgg ctcccgcatc cgcacgccgc acctggacgc
781 gctggcggcc ggcggggtgc tcctggacaa ctactacacg cagccgctgt gcacgccgtc
841 gcggagccag ctgctcactg gccgctacca gatccgtaca ggtttacagc accaaataat
901 ctggccctgt cagcccagct gtgttcctct ggatgaaaaa ctcctgcccc agctcctaaa
961 agaagcaggt tatactaccc atatggtcgg aaaatggcac ctgggaatgt accggaaaga
1021 atgccttcca acccgccgag gatttgatac ctactttgga tatctcctgg gtagtgaaga
1081 ttattattcc catgaacgct gtacattaat tgacgctctg aatgtcacac gatgtgctct
1141 tgattttcga gatggcgaag aagttgcaac aggatataaa aatatgtatt caacaaacat
1201 attcaccaaa agggctatag ccctcataac taaccatcca ccagagaagc ctctgtttct
1261 ctaccttgct ctccagtctg tgcatgagcc ccttcaggtc cctgaggaat acttgaagcc
1321 atatgacttt atccaagaca agaacaggca tcactatgca ggaatggtgt cccttatgga
1381 tgaagcagta ggaaatgtca ctgcagcttt aaaaagcagt gggctctgga acaacacggt
1441 gttcatcttt tctacagata acggagggca gactttggca gggggtaata actggcccct
1501 tcgaggaaga aaatggagcc tgtgggaagg aggcgtccga ggggtgggct ttgtggcaag
1561 ccccttgctg aagcagaagg gcgtgaagaa ccgggagctc atccacatct ctgactggct
1621 gccaacactc gtgaagctgg ccaggggaca caccaatggc acaaagcctc tggatggctt
1681 cgacatgtgg aaaaccatca gtgaaggaag cccatccccc agaattgagc tgctgcataa
1741 tattgacccg aacttcgtgg actcttcacc gtgtcccagg aacagcatgg ctccagcaaa
1801 ggatgactct tctcttccag aatattcagc ctttaacaca tctgtccatg ctgcaattag
1861 acatggaaat tggaaactcc tcacgggcta cccaggctgt ggttactggt tccctccacc
1921 gtctcaatac aatgtttctg agataccctc atcagaccca ccaaccaaga ccctctggct
1981 ctttgatatt gatcgggacc ctgaagaaag acatgacctg tccagagaat atcctcacat
2041 cgtcacaaag ctcctgtccc gcctacagtt ctaccataaa cactcagtcc ccgtgtactt
2101 ccctgcacag gacccccgct gtgatcccaa ggccactggg gtgtggggcc cttggatgta
2161 ggatttcagg gaggctagaa aacctttcaa ttggaagttg gacctcaggc cttttctcac
2221 gactcttgtc tcatttgtta tcccaacctg ggttcacttg gcccttctct tgctcttaaa
2281 ccacaccgag gtgtctaatt tcaaccccta atgcatttaa gaagctgata aaatctgcaa
2341 cactcctgct gttggctgga gcatgtgtct agaggtggct ggagcatgtg tctagaggtg
2401 ggggtggctg ggtttatccc cctttcctaa gccttgggac agctgggaac ttaacttgaa
2461 ataggaagtt ctcactgaat cctggaggct ggaacagctg gctcttttag actcacaagt
2521 cagacgttcg attcccctct gccaatagcc agttttattg gagtgaatca catttcttac
2581 gcaaatgaag ggagcagaca gtgattaatg gttctgttgg caaggcttct ccctgtcggt
2641 gaaggatcat gttcaggcac tccaagtgaa ccacccctct tggttcaccc cttactcact
2701 tatctcatca cagagcataa ggcccatttt gttgttcagg tcaacagcaa aatgcctgca
2761 ccatgactgt ggcttttaaa ataaagaaat gtgtttttat cg
//