LOCUS HUMDCC 2256 bp mRNA linear HUM 19-JAN-1994
DEFINITION Human colorectal tumor suppressor mRNA (DCC), 5' end.
ACCESSION M32292
VERSION M32292.1
KEYWORDS cell surface glycoprotein; colorectal tumor suppressor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2256)
AUTHORS Fearon,E.R., Cho,K.R., Nigro,J.M., Kern,S.E., Simons,J.W.,
Ruppert,J.M., Hamilton,S.R., Preisinger,A.C., Thomas,G.,
Kinzler,K.W. and Vogelstein,B.
TITLE Identification of a chromosome 18q gene that is altered in
colorectal cancers
JOURNAL Science 247 (4938), 49-56 (1990)
PUBMED 2294591
COMMENT Original source text: Human brain, cDNA to mRNA.
Authorin submission for [1] kindly submitted by B.Vogelstein,
23-FEB-1990.
FEATURES Location/Qualifiers
source 1..2256
/db_xref="H-InvDB:HIT000195461"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 7..>2256
/note="colorectal tumor suppressor (put.); putative"
/codon_start=1
/protein_id="AAA35751.1"
/translation="MENSLRCVWVPKLAFVLFGASLLSAHLQVTGFQIKAFTALRFLS
EPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNI
LHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLK
CEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPA
SSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRG
EEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFL
NHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVK
SDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWR
PPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEW
GPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCT
EVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSA
PPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYL
FTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNC
IIMSWTPPLN"
BASE COUNT 625 a 536 c 535 g 560 t
ORIGIN Chromosome 18q.
1 tgaaatatgg agaatagtct tagatgtgtt tgggtaccca agctggcttt tgtactcttc
61 ggagcttcct tgctcagcgc gcatcttcaa gtaaccggtt ttcaaattaa agctttcaca
121 gcactgcgct tcctctcaga accttctgat gccgtcacaa tgcggggagg aaatgtcctc
181 ctcgactgct ccgcggagtc cgaccgagga gttccagtga tcaagtggaa gaaagatggc
241 attcatctgg ccttgggaat ggatgaaagg aagcagcaac tttcaaatgg gtctctgctg
301 atacaaaaca tacttcattc cagacaccac aagccagatg agggacttta ccaatgtgag
361 gcatctttag gagattctgg ctcaattatt agtcggacag caaaagttgc agtagcagga
421 ccactgaggt tcctttcaca gacagaatct gtcacagcct tcatgggaga cacagtgcta
481 ctcaagtgtg aagtcattgg ggagcccatg ccaacaatcc actggcagaa gaaccaacaa
541 gacctgactc caatcccagg tgactcccga gtggtggtct tgccctctgg agcattgcag
601 atcagccgac tccaaccggg ggacattgga atttaccgat gctcagctcg aaatccagcc
661 agctcaagaa caggaaatga agcagaagtc agaattttat cagatccagg actgcataga
721 cagctgtatt ttctgcaaag accatccaat gtagtagcca ttgaaggaaa agatgctgtc
781 ctggaatgtt gtgtttctgg ctatcctcca ccaagtttta cctggttacg aggcgaggaa
841 gtcatccaac tcaggtctaa aaagtattct ttattgggtg gaagcaactt gcttatctcc
901 aatgtgacag atgatgacag tggaatgtat acctgtgttg tcacatataa aaatgagaat
961 attagtgcct ctgcagagct cacagtcttg gttccgccat ggtttttaaa tcatccttcc
1021 aacctgtatg cctatgaaag catggatatt gagtttgaat gtacagtctc tggaaagcct
1081 gtgcccactg tgaattggat gaagaatgga gatgtggtca ttcctagtga ttattttcag
1141 atagtgggag gaagcaactt acggatactt ggggtggtga agtcagatga aggcttttat
1201 caatgtgtgg ctgaaaatga ggctggaaat gcccagacca gtgcacagct cattgtccct
1261 aagcctgcaa tcccaagctc cagtgtcctc ccttcggctc ccagagatgt ggtccctgtc
1321 ttggtttcca gccgatttgt ccgtctcagc tggcgcccac ctgcagaagc gaaagggaac
1381 attcaaactt tcacggtctt tttctccaga gaaggtgaca acagggaacg agcattgaat
1441 acaacacagc ctgggtccct tcagctcact gtgggaaacc tgaagccaga agccatgtac
1501 acctttcgag ttgtggctta caatgaatgg ggaccgggag agagttctca acccatcaag
1561 gtggccacac agcctgagtt gcaagttcca gggccagtag aaaacctgca agctgtatct
1621 acctcaccta cctcaattct tattacctgg gaaccccctg cctatgcaaa cggtccagtc
1681 caaggttaca gattgttctg cactgaggtg tccacaggaa aagaacagaa tatagaggtt
1741 gatggactat cttataaact ggaaggcctg aaaaaattca ccgaatatag tcttcgattc
1801 ttagcttata atcgctatgg tccgggcgtc tctactgatg atataacagt ggttacactt
1861 tctgacgtgc caagtgcccc gcctcagaac gtctccctgg aagtggtcaa ttcaagaagt
1921 atcaaagtta gctggctgcc tcctccatca ggaacacaaa atggatttat taccggctat
1981 aaaattcgac acagaaagac gacccgcagg ggtgagatgg aaacactgga gccaaacaac
2041 ctctggtacc tattcacagg actggagaaa ggaagtcagt acagtttcca ggtgtcagcc
2101 atgacagtca atggtactgg accaccttcc aactggtata ctgcagagac tccagagaat
2161 gatctagatg aatctcaagt tcctgatcaa ccaagctctc ttcatgtgag gccccagact
2221 aactgcatca tcatgagttg gactcctccc ttgaac
//