LOCUS HUMMSCA 1719 bp mRNA linear HUM 27-APR-1993
DEFINITION Human GT mitochondrial solute carrier protein homologue mRNA,
complete cds.
ACCESSION M31659
VERSION M31659.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1719)
AUTHORS Zarrilli,R., Oates,E.L., McBride,O.W., Lerman,M.I., Chan,J.Y.,
Santisteban,P., Ursini,M.V., Notkins,A.L. and Kohn,L.D.
TITLE Sequence and chromosomal assignment of a novel cDNA identified by
immunoscreening of a thyroid expression library: similarity to a
family of mitochondrial solute carrier proteins
JOURNAL Mol. Endocrinol. 3 (9), 1498-1505 (1989)
PUBMED 2575220
COMMENT Original source text: Human (Graves' disease patient) thyroid, cDNA
to mRNA, clone hGT-7.
The region between base pairs 195-297 appears to be an aberrantly
spliced intron. An acceptor splice consensus sequence is present
at the 3' end of this region, but no donor site is found at its 5'
end. Upon readthrough of this intron boundary, a stop codon is
found at positions 245-247.
FEATURES Location/Qualifiers
source 1..1719
/db_xref="H-InvDB:HIT000195437"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
mRNA <1..1719
/product="GT mRNA"
CDS join(65..194,298..1217)
/note="GT mitochondrial solute carrier protein homologue;
putative"
/codon_start=1
/protein_id="AAA36329.1"
/translation="MAAATAAAALAAADPPPAMPGAAGAGGPTTRRDFYWLRSFLAGS
IAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAMMIR
IFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTDPVDMVRVRLAF
QVKGEHRYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVGL
SHAPTLLGSPSSDNPNVLVLKTHVNLLCGGVARAIAQTISYPFDVTRRRMQLGTVLPE
FEKCLTMRDTMKYDYGHHGIRKGLYRGLSLNYIRCIPSQAVAFYNIRTYEAVFSPQLK
KNYGWFFLIHSQREK"
exon <65..194
/note="GT mitochondrial solute carrier protein homologue;
putative"
exon 298..>1217
/note="GT mitochondrial solute carrier protein homologue;
putative"
regulatory 1698..1703
/regulatory_class="polyA_signal_sequence"
BASE COUNT 463 a 344 c 370 g 542 t
ORIGIN Chromosome 10.
1 cctatggtcc cgtccggtgt tctgtaagtt ggcaacctag gctcctgacg cgaccctggt
61 cctgatggcg gcggcgacgg ccgcggcagc cctggcggcg gccgatcccc ctcccgcaat
121 gccaggggcg gcaggggccg gagggcccac aacccgcaga gacttctact ggctgcgctc
181 ctttctggcc gggagaagaa gaggaggtta cttcaaacag aacctggcag ttggattaat
241 accttgaagt gtctgtctcc ataaccacat tttagcaaga ttcccagcct tcctcaggta
301 ttgctggatg ctgtgccaaa acaacagttg ctccattgga tcgagtaaag gttttattac
361 aagctcacaa tcaccattac aagcatttag gagtattttc tgcattgcgt gctgttcctc
421 aaaaagaagg attccttgga ttgtataaag gaaatggtgc aatgatgatt cgaatctttc
481 cctatggtgc aatccagttt atggcatttg agcattataa aacgttaatt actacgaagc
541 tgggaatttc aggtcatgtg cacagattaa tggctggatc catggcaggt atgacagcag
601 ttatctgtac tgaccctgtt gacatggtta gggtccgcct agcattccag gtgaaagggg
661 aacaccgcta tacaggaatt attcatgctt tcaaaacaat ttatgcaaag gaaggtggtt
721 tctttggatt ttacagaggt ctgatgccta ctattttagg aatggctcca tatgcaggtg
781 tttcattttt tacttttggt accttgaaga gtgttgggct ttcccatgct cctacccttc
841 ttggcagtcc ttcatcagac aatcctaatg tcttagtttt gaaaactcat gtaaacttac
901 tttgtggtgg tgttgctcga gcaatagcgc agacaatatc ctacccattt gatgtgactc
961 gtcggcgaat gcaattagga actgttctgc cggaatttga aaagtgcctt accatgcggg
1021 atactatgaa gtatgactat ggacaccatg gaattcgaaa aggactctat cgtggtttat
1081 ctcttaatta cattcgctgt attccctctc aagcagtggc tttctacaac atacgaactt
1141 atgaagcagt tttttcacct caactaaaaa aaaattatgg ttggtttttc ttaatacatt
1201 ctcagaggga gaaatgaaac attactataa ttgtgggggg aacattactt gaatggggat
1261 atttaccctg tcacagagcc atggtatttt agtacttgat tatttttctt tagtcagatc
1321 agaactgctt accatacttt ttagatgcgc caaacattat accttagaac attgaagaaa
1381 atatcgcagc taagctgatg cctggctaaa ccgctttaat gttttatttg gaagtagaaa
1441 ctagctttac ggggttcaag aggttggcca ttagctttcg tcatgctgtt caaagttttt
1501 aattgttatc ggtttttaaa agactgacag tgtttattat attaaaataa ggttatattg
1561 caatagaata atagagaatt gaatttttaa gttgctatga aacagtccag ccattgacat
1621 tttatttttg ttatctctct tctcacaatt atgctccact ggataatagg aaaaacactt
1681 ctttccttca ttttttaaat aaaaattaat gtttgattt
//