LOCUS HUMPRPC4B 2178 bp mRNA linear HUM 27-APR-1993
DEFINITION Human proline-rich protein (PRP) mRNA, complete cds.
ACCESSION M31452
VERSION M31452.1
KEYWORDS C4b-binding protein; proline-rich protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2178)
AUTHORS Matsuguchi,T., Okamura,S., Aso,T., Sata,T. and Niho,Y.
TITLE Molecular cloning of the cDNA coding for proline-rich protein
(PRP): identity of PRP as C4b-binding protein
JOURNAL Biochem. Biophys. Res. Commun. 165 (1), 138-144 (1989)
PUBMED 2590215
REFERENCE 2 (sites)
AUTHORS Aso,T., Okamura,S., Matsuguchi,T., Sakamoto,N., Sata,T. and Niho,Y.
TITLE Genomic organization of the alpha chain of the human C4b-binding
protein gene
JOURNAL Biochem. Biophys. Res. Commun. 174 (1), 222-227 (1991)
PUBMED 1989602
COMMENT Original source text: Human liver, cDNA to mRNA, clones
lambda-PRP[2,4,6,7,8].
FEATURES Location/Qualifiers
source 1..2178
/db_xref="H-InvDB:HIT000195422"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="12p13.2"
/tissue_type="liver"
gene 1..2178
/gene="C4bp"
mRNA <1..2178
/gene="C4bp"
/product="C4b-binding protein alpha chain"
/note="PRP mRNA"
CDS 139..1932
/gene="C4bp"
/note="proline-rich protein"
/codon_start=1
/product="C4b-binding protein alpha chain"
/protein_id="AAA36507.1"
/translation="MHPPKTPSGALHRKRKMAAWPFSRLWKVSDPILFQMTLIAALLP
AVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEW
VYNTFCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRG
VGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCT
VENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGS
SVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHP
GYKPTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYG
DEISFSCHETSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEI
IYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEPENVT
IQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCEQVLTGKRLMQCLPNPEDVK
MALEVYKLSLEIEQLELQRDSARQSTLDKEL"
sig_peptide 139..282
/gene="C4bp"
/note="proline-rich protein"
mat_peptide 283..1929
/gene="C4bp"
/product="C4b-binding protein alpha chain"
/note="proline-rich protein"
BASE COUNT 629 a 480 c 468 g 601 t
ORIGIN Chromosome 12p13.2.
1 aaaactctga tctggggagg aaccaggact acatagatca aggcagtttt cttctttgag
61 aaactatccc agatatcatc atagagtctt ctgctcttcc tcaactacca aagaaaaaca
121 tcagcgaagc agcaggccat gcacccccca aaaactccat ctggggctct tcatagaaaa
181 aggaaaatgg cagcctggcc cttctccagg ctgtggaaag tctctgatcc aattctcttc
241 caaatgacct tgatcgctgc tctgttgcct gctgttcttg gcaattgtgg tcctccaccc
301 actttatcat ttgctgcccc gatggatatt acgttgactg agacacgctt caaaactgga
361 actactctga aatacacctg cctccctggc tacgtcagat cccattcaac tcagacgctt
421 acctgtaatt ctgatggcga atgggtgtat aacaccttct gtatctacaa acgatgcaga
481 cacccaggag agttacgtaa tgggcaagta gagattaaga cagatttatc ttttggatca
541 caaatagaat tcagctgttc agaaggattt ttcttaattg gctcaaccac tagtcgttgt
601 gaagtccaag atagaggagt tggctggagt catcctctcc cacaatgtga aattgtcaag
661 tgtaagcctc ctccagacat caggaatgga aggcacagcg gtgaagaaaa tttctacgca
721 tacggctttt ctgtcaccta cagctgtgac ccccgcttct cactcttggg ccatgcctcc
781 atttcttgca ctgtggagaa tgaaacaata ggcgtttgga gaccaagccc tcctacctgt
841 gaaaaaatca cctgtcgcaa gccagatgtt tcacatgggg aaatggtctc tggatttgga
901 cccatctata attacaaaga cactattgtg tttaagtgcc aaaaaggttt tgttctcaga
961 ggcagcagtg taattcattg tgatgctgat agcaaatgga atccttctcc tcctgcttgt
1021 gagcccaata gttgtattaa tttaccagac attccacatg cttcctggga aacatatcct
1081 aggccgacaa aagaggatgt gtatgttgtt gggactgtgt taaggtaccg ctgtcatcct
1141 ggctacaaac ccactacaga tgagcctacg actgtgattt gtcagaaaaa tttgagatgg
1201 accccatacc aaggatgtga ggcgttatgt tgccctgaac caaagctaaa taatggtgaa
1261 atcactcaac acaggaaaag tcgtcctgcc aatcactgtg tttatttcta tggagatgag
1321 atttcatttt catgtcatga gaccagtagg ttttcagcta tatgccaagg agatggcacg
1381 tggagtcccc gaacaccatc atgtggagac atttgcaatt ttcctcctaa aattgcccat
1441 gggcattata aacaatctag ttcatacagc tttttcaaag aagagattat atatgaatgt
1501 gataaaggct acattctggt cggacaggcg aaactctcct gcagttattc acactggtca
1561 gctccagccc ctcaatgtaa agctctgtgt cggaaaccag aattagtgaa tggaaggttg
1621 tctgtggata aggatcagta tgttgagcct gaaaatgtca ccatccaatg tgattctggc
1681 tatggtgtgg ttggtcccca aagtatcact tgctctggga acagaacctg gtacccagag
1741 gtgcccaagt gtgagtggga gacccccgaa ggctgtgaac aagtgctcac aggcaaaaga
1801 ctcatgcagt gtctcccaaa cccagaggat gtgaaaatgg ccctggaggt atataagctg
1861 tctctggaaa ttgaacaact ggaactacag agagacagcg caagacaatc cactttggat
1921 aaagaactat aatttttctc aaaagaagga ggaaaaggtg tcttgctggc ttgcctcttg
1981 caattcaata cagatcagtt tagcaaatct actgtcaatt tggcagtgat attcatcata
2041 ataaatatct agaaatgata atttgctaaa gtttagtgct ttgagattgt gaaattatta
2101 atcatcctct gtgtggctca tgtttttgct tttcaacaca caaagcacaa attttttttc
2161 gattaaaaat gtatgtat
//