LOCUS HUMCOL4A5 3517 bp mRNA linear HUM 01-NOV-1994
DEFINITION Human collagen type IV alpha 5 chain mRNA, 3' end.
ACCESSION M31115
VERSION M31115.1
KEYWORDS collagen.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3517)
AUTHORS Hostikka,S.L., Eddy,R.L., Byers,M.G., Hoyhtya,M., Shows,T.B. and
Tryggvason,K.
TITLE Identification of a distinct type IV collagen alpha chain with
restricted kidney distribution and assignment of its gene to the
locus of X chromosome-linked Alport syndrome
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (4), 1606-1610 (1990)
PUBMED 1689491
COMMENT Original source text: Human placenta, cDNA to mRNA, clones PL-31,
MD-6, PC-4, and PL-35.
Draft entry and computer-readable sequence for [1] kindly submitted
by K.Tryggvason, 05-JAN-1990.
FEATURES Location/Qualifiers
source 1..3517
/db_xref="H-InvDB:HIT000195399"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="Xq22"
gene 1..3517
/gene="COL4A5"
mRNA <1..3483
/gene="COL4A5"
/note="collagen mRNA (alt.)"
CDS <1..2319
/gene="COL4A5"
/note="collagen type IV alpha 5 chain"
/codon_start=1
/protein_id="AAA52045.1"
/db_xref="GDB:G00-120-596"
/translation="GRSGVPGLKGDDGLQGQPGLPGPTGEKGSKGEPGLPGPPGPMDP
NLLGSKGEKGEPGLPGIPGVSGPKGYQGLPGDPGQPGLSGQPGLPGPPGPKGNPGLPG
QPGLIGPPGLKGTIGDMGFPGPQGVEGPPGPSGVPGQPGSPGLPGQKGDKGDPGISSI
GLPGLPGPKGEPGLPGYPGNPGIKGSVGDPGLPGLPGTPGAKGQPGLPGFPGTPGPPG
PKGISGPPGNPGLPGEPGPVGGGGHPGQPGPPGEKGKPGQDGIPGPAGQKGEPGQPGF
GNPGPPGLPGLSGQKGDGGLPGIPGNPGLPGPKGEPGFHGFPGVQGPPGPPGSPGPAL
EGPKGNPGPQGPPGRPGLPGPEGPPGLPGNGGIKGEKGNPGQPGLPGLPGLKGDQGPP
GLQGNPGRPGLNGMKGDPGLPGVPGFPGMKGPSGVPGSAGPEGEPGLIGPPGPPGLPG
PSGQSIIIKGDAGPPGIPGQPGLKGLPGPQGPQGLPGPTGPPGDPGRNGLPGFDGAGG
RKGDPGLPGQPGTRGLDGPPGPDGLQGPPGPPGTSSVAHGFLITRHSQTTDAPQCPQG
TLQVYEGFSLLYVQGNKRAHGQDLGTAGSCLRRFSTMPFMFCNINNVCNFASRNDYSY
WLSTPEPMPMSMQPLKGQSIQPFISRCAVCEAPAVVIAVHSQTIQIPHCPQGWDSLWI
GYSFMMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHGRGTCNYYANSYSFWLATVD
VSDMFSKPQSETLKAGDLRTRISRCQVCMKRT"
regulatory 3451..3456
/regulatory_class="polyA_signal_sequence"
/gene="COL4A5"
/note="putative"
regulatory 3462..3468
/regulatory_class="polyA_signal_sequence"
/gene="COL4A5"
/note="putative"
BASE COUNT 941 a 824 c 823 g 929 t
ORIGIN
1 ggcaggagtg gtgtacctgg tcttaaaggt gatgatggct tgcagggtca gccaggactt
61 cctggcccta caggagaaaa aggtagtaaa ggagagcctg gccttccagg ccctcctgga
121 ccaatggatc caaatcttct gggctcaaaa ggagagaagg gggaacctgg cttaccaggt
181 atacctggag tttcagggcc aaaaggttat cagggtttgc ctggagaccc agggcaacct
241 ggactgagtg gacaacctgg attaccagga ccaccaggtc ccaaaggtaa ccctggtctc
301 cctggacagc caggtcttat aggacctcct ggacttaaag gaaccatcgg tgatatgggt
361 tttccagggc ctcagggtgt ggaagggcct cctggacctt ctggagttcc tggacaacct
421 ggctccccag gattacctgg acagaaaggc gacaaaggtg atcctggtat ttcaagcatt
481 ggtcttccag gtcttcctgg tccaaagggt gagcctggtc tgcctggata cccagggaac
541 cctggtatca aaggttctgt gggagatcct ggtttgcccg gattaccagg aacccctgga
601 gcaaaaggac aaccaggcct tcctggattc ccaggaaccc caggccctcc tggaccaaaa
661 ggtattagtg gccctcctgg gaaccccggc cttccaggag aacctggtcc tgtaggtggt
721 ggaggtcatc ctgggcaacc agggcctcca ggcgaaaaag gcaaacccgg tcaagatggt
781 attcctggac cagctggaca gaagggtgaa ccaggtcaac caggctttgg aaacccagga
841 ccccctggac ttccaggact ttctggccaa aagggtgatg gaggattacc tgggattcca
901 ggaaatcctg gccttccagg tccaaagggc gaaccaggct ttcacggttt ccctggtgtg
961 cagggtcccc caggccctcc tggttctccg ggtccagctc tggaaggacc taaaggcaac
1021 cctgggcccc aaggtcctcc tgggagacca ggtctaccag gtccagaagg tcctccaggt
1081 ctccctggaa atggaggtat taaaggagag aagggaaatc caggccaacc tgggctacct
1141 ggcttgcctg gtttgaaagg agatcaagga ccaccaggac tccagggtaa tcctggccgg
1201 ccgggtctca atggaatgaa aggagatcct ggtctccctg gtgttccagg attcccaggc
1261 atgaaaggac ccagtggagt acctggatca gctggccctg agggggaacc gggacttatt
1321 ggtcctccag gtcctcctgg attacctggt ccttcaggac agagtatcat aattaaagga
1381 gatgctggtc ctccaggaat ccctggccag cctgggctaa agggtctacc aggaccccaa
1441 ggacctcaag gcttaccagg tccaactggc cctccaggag atcctggacg caatggactc
1501 cctggctttg atggtgcagg agggcgcaaa ggagacccag gtctgccagg acagccaggt
1561 acccgtggtt tggatggtcc ccctggtcca gatggattgc aaggtccccc aggtccccct
1621 ggaacctcct ctgttgcaca tggatttctt attacacgcc acagccagac aacggatgca
1681 ccacaatgcc cacagggaac acttcaggtc tatgaaggct tttctctcct gtatgtacaa
1741 ggaaataaaa gagcccacgg tcaagacttg gggacggctg gcagctgcct tcgtcgcttt
1801 agtaccatgc ctttcatgtt ctgcaacatc aataatgttt gcaactttgc ttcaagaaat
1861 gactattctt actggctctc taccccagag cccatgccaa tgagcatgca acccctaaag
1921 ggccagagca tccagccatt cattagtcga tgtgcagtat gtgaagctcc agctgtggtg
1981 atcgcagttc acagtcagac gatccagatt ccccattgtc ctcagggatg ggattctctg
2041 tggattggtt attccttcat gatgcataca agtgcagggg cagaaggctc aggtcaagcc
2101 ctagcctccc ctggttcctg cttggaagag tttcgttcag ctcccttcat cgaatgtcat
2161 gggaggggta cctgtaacta ctatgccaac tcctacagct tttggctggc aactgtagat
2221 gtgtcagaca tgttcagtaa acctcagtca gaaacgctga aagcaggaga cttgaggaca
2281 cgaattagcc gatgtcaagt gtgcatgaag aggacataac attttgaaga attccttttg
2341 tgttttaaaa tgtgatatat atatatataa aattcctagg atgcagtgtc tcattgtccc
2401 caactttact actgctgccg tcaatggtgc tactatatat gatcaagata acatgctgac
2461 tagtaaccat gaagattcag atgtacctca gcaatgcgcc agagcaaagt ctctattatt
2521 tttctactaa agaaataagg aagtgaattt actttttggg tccagaatga ctttctccaa
2581 gaattataag atgaaaatta tatattttgc ccagttacta aaatggtaca ttaaaaattc
2641 aattaagaga agagtcacat tgagtaaaat aaaagactgc agtttgtggg aagaattatt
2701 tttcacggtg ctactaatcc tgctgtatcc cgggttttta atataaaggt gttaagctta
2761 ttttgctttg taagtaaaga atgtgtatat tgtgaacagc cttttagctc aaaatgttga
2821 gtcatttaca tatgacatag catgaatcac tctttacaga aaatgtagga aaccctagaa
2881 tacagacagc aatattttat attcatgttt atcaaagtga gaggacttat attcctacat
2941 caagttacta ctgagagtaa atttattttg agttttatcc cgtaagttct gttttgattt
3001 tttttaaaaa acaaaccctt ttagtcactt taatcagaat tttaaatgtt catgttacat
3061 accaaattat aatatctaat ggagcaattt gtcttttgct atattctcca agattatctc
3121 ttaagaccat atgccccctg ttttaatgtt tcttacatct tgtttttact catttctgac
3181 tggacaaagt tcttccaaac aattctgaga aacaaaaaca cacacgcaga attaacaatt
3241 cttttccctg tgcttcttat gtaagaatcc tcctgtggcc tctgcttgta cagaactggg
3301 aaacaacact tggttagtct cttttaagtt acaaaaagcc aattgatgtt tcttattctt
3361 tttaaatttt aaatattttg ttataaatac tcacaggata ccttatttcc ctagctatca
3421 tctcctgact taatgttttt taaacccacc aatataaatt taattaaaga tatatgttgt
3481 aaacccgcca aacgaaaagc tctataactt tgaattc
//