LOCUS HUMARXC 1230 bp mRNA linear HUM 31-OCT-1994
DEFINITION Human amphiregulin (AR) mRNA, complete cds, clones lambda-AR1 and
lambda-AR2.
ACCESSION M30704
VERSION M30704.1
KEYWORDS amphiregulin; growth regulator; tumor inhibitory factor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1230)
AUTHORS Plowman,G.D., Green,J.M., McDonald,V.L., Neubauer,M.G.,
Disteche,C.M., Todaro,G.J. and Shoyab,M.
TITLE The amphiregulin gene encodes a novel epidermal growth
factor-related protein with tumor-inhibitory activity
JOURNAL Mol. Cell. Biol. 10 (5), 1969-1981 (1990)
PUBMED 2325643
COMMENT Original source text: Homo sapiens breast carcinoma cDNA to mRNA.
Draft entry and computer-readable sequence for [1] kindly submitted
by G.D.Plowman, 18-DEC-1989.
FEATURES Location/Qualifiers
source 1..1230
/db_xref="H-InvDB:HIT000195384"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="4q13-q21"
/cell_line="MCF-7"
/tissue_type="breast carcinoma"
gene 1..1230
/gene="AREG"
mRNA 1..1230
/gene="AREG"
/note="G00-119-697"
CDS 210..968
/gene="AREG"
/note="precursor"
/codon_start=1
/product="amphiregulin"
/protein_id="AAA51781.1"
/db_xref="GDB:G00-119-697"
/translation="MRAPLLPPAPVVLSLLILGSGHYAAGLDLNDTYSGKREPFSGDH
SADGFEVTSRSEMSSGSEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSV
RVEQVVKPPQNKTESENTSDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECK
YIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAAIAAFMSAVILTAVAV
ITVQLRRQYVRKYEGEAEERKKLRQENGNVHAIA"
sig_peptide 210..266
/gene="AREG"
/note="G00-119-697"
mat_peptide 510..962
/gene="AREG"
/product="amphiregulin"
/note="alternative; G00-119-697"
mat_peptide 528..962
/gene="AREG"
/product="amphiregulin"
/note="alternative; G00-119-697"
BASE COUNT 375 a 273 c 285 g 297 t
ORIGIN
1 agacgttcgc acacctgggt gccagcgccc cagaggtccc gggacagccc gaggcgccgc
61 gcccgccgcc ccgagctccc caagccttcg agagcggcgc acactcccgg tctccactcg
121 ctcttccaac acccgctcgt tttgcggcag ctcgtgtccc agagaccgag ttgccccaga
181 gaccgagacg ccgccgctgc gaaggaccaa tgagagcccc gctgctaccg ccggcgccgg
241 tggtgctgtc gctcttgata ctcggctcag gccattatgc tgctggattg gacctcaatg
301 acacctactc tgggaagcgt gaaccatttt ctggggacca cagtgctgat ggatttgagg
361 ttacctcaag aagtgagatg tcttcaggga gtgagatttc ccctgtgagt gaaatgcctt
421 ctagtagtga accgtcctcg ggagccgact atgactactc agaagagtat gataacgaac
481 cacaaatacc tggctatatt gtcgatgatt cagtcagagt tgaacaggta gttaagcccc
541 cccaaaacaa gacggaaagt gaaaatactt cagataaacc caaaagaaag aaaaagggag
601 gcaaaaatgg aaaaaataga agaaacagaa agaagaaaaa tccatgtaat gcagaatttc
661 aaaatttctg cattcacgga gaatgcaaat atatagagca cctggaagca gtaacatgca
721 aatgtcagca agaatatttc ggtgaacggt gtggggaaaa gtccatgaaa actcacagca
781 tgattgacag tagtttatca aaaattgcat tagcagccat agctgccttt atgtctgctg
841 tgatcctcac agctgttgct gttattacag tccagcttag aagacaatac gtcaggaaat
901 atgaaggaga agctgaggaa cgaaagaaac ttcgacaaga gaatggaaat gtacatgcta
961 tagcataact gaagataaaa ttacaggata tcacattgga gtcactgcca agtcatagcc
1021 ataaatgatg agtcggtcct ctttccagtg gatcataaga caatggaccc tttttgttat
1081 gatggtttta aactttcaat tgtcactttt tatgctattt ctgtatataa aggtgcacga
1141 aggtaaaaag tattttttca agttgtaaat aatttattta atatttaatg gaagtgtatt
1201 tattttacag ctcattaaac ttttttaacc
//