LOCUS HUMCAM1V 2811 bp mRNA linear HUM 31-OCT-1994
DEFINITION Human vascular cell adhesion molecule 1 mRNA, complete cds.
ACCESSION M30257
VERSION M30257.1
KEYWORDS cell adhesion molecule; endothelial protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2811)
AUTHORS Osborn,L., Hession,C., Tizard,R., Vassallo,C., Luhowskyj,S.,
Chi-Rosso,G. and Lobb,R.
TITLE Direct expression cloning of vascular cell adhesion molecule 1, a
cytokine-induced endothelial protein that binds to lymphocytes
JOURNAL Cell 59 (6), 1203-1211 (1989)
PUBMED 2688898
COMMENT Original source text: Human umbilical vein endothelial cell line
4th passage HUVECs, cDNA to mRNA, clone 41.
Draft entry and computer-readable sequence for [1] kindly submitted
by R.R.Lobb 30-NOV-1989.
FEATURES Location/Qualifiers
source 1..2811
/db_xref="H-InvDB:HIT000195358"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="1p32-p31"
gene 1..2811
/gene="VCAM1"
CDS 107..2050
/gene="VCAM1"
/note="vascular cell adhesion molecule 1 precursor"
/codon_start=1
/protein_id="AAA51917.1"
/db_xref="GDB:G00-127-922"
/translation="MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVS
LTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESR
KLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMK
SQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQ
VYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATL
TLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMSGGLVNGSSVTVSCK
VPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQ
AKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAP
KILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTP
KDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKA
QLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMI
IYFARKANMKGSYSLVEAQKSKV"
sig_peptide 107..178
/gene="VCAM1"
/note="vascular cell adhesion molecule 1 signal peptide
(put.); putative"
mat_peptide 179..2047
/gene="VCAM1"
/product="vascular cell adhesion molecule 1; G00-127-922"
BASE COUNT 869 a 528 c 611 g 803 t
ORIGIN
1 cgggcctcac tggcttcagg agctgaatac cctcccaggc acacacaggt gggacacaaa
61 taagggtttt ggaaccacta ttttctcatc acgacagcaa cttaaaatgc ctgggaagat
121 ggtcgtgatc cttggagcct caaatatact ttggataatg tttgcagctt ctcaagcttt
181 taaaatcgag accaccccag aatctagata tcttgctcag attggtgact ccgtctcatt
241 gacttgcagc accacaggct gtgagtcccc atttttctct tggagaaccc agatagatag
301 tccactgaat gggaaggtga cgaatgaggg gaccacatct acgctgacaa tgaatcctgt
361 tagttttggg aacgaacact cttacctgtg cacagcaact tgtgaatcta ggaaattgga
421 aaaaggaatc caggtggaga tctactcttt tcctaaggat ccagagattc atttgagtgg
481 ccctctggag gctgggaagc cgatcacagt caagtgttca gttgctgatg tatacccatt
541 tgacaggctg gagatagact tactgaaagg agatcatctc atgaagagtc aggaatttct
601 ggaggatgca gacaggaagt ccctggaaac caagagtttg gaagtaacct ttactcctgt
661 cattgaggat attggaaaag ttcttgtttg ccgagctaaa ttacacattg atgaaatgga
721 ttctgtgccc acagtaaggc aggctgtaaa agaattgcaa gtctacatat cacccaagaa
781 tacagttatt tctgtgaatc catccacaaa gctgcaagaa ggtggctctg tgaccatgac
841 ctgttccagc gagggtctac cagctccaga gattttctgg agtaagaaat tagataatgg
901 gaatctacag cacctttctg gaaatgcaac tctcacctta attgctatga ggatggaaga
961 ttctggaatt tatgtgtgtg aaggagttaa tttgattggg aaaaacagaa aagaggtgga
1021 attaattgtt caagcattcc ctagagatcc agaaatcgag atgagtggtg gcctcgtgaa
1081 tgggagctct gtcactgtaa gctgcaaggt tcctagcgtg tacccccttg accggctgga
1141 gattgaatta cttaaggggg agactattct ggagaatata gagtttttgg aggatacgga
1201 tatgaaatct ctagagaaca aaagtttgga aatgaccttc atccctacca ttgaagatac
1261 tggaaaagct cttgtttgtc aggctaagtt acatattgat gacatggaat tcgaacccaa
1321 acaaaggcag agtacgcaaa cactttatgt caatgttgcc cccagagata caaccgtctt
1381 ggtcagccct tcctccatcc tggaggaagg cagttctgtg aatatgacat gcttgagcca
1441 gggctttcct gctccgaaaa tcctgtggag caggcagctc cctaacgggg agctacagcc
1501 tctttctgag aatgcaactc tcaccttaat ttctacaaaa atggaagatt ctggggttta
1561 tttatgtgaa ggaattaacc aggctggaag aagcagaaag gaagtggaat taattatcca
1621 agttactcca aaagacataa aacttacagc ttttccttct gagagtgtca aagaaggaga
1681 cactgtcatc atctcttgta catgtggaaa tgttccagaa acatggataa tcctgaagaa
1741 aaaagcggag acaggagaca cagtactaaa atctatagat ggcgcctata ccatccgaaa
1801 ggcccagttg aaggatgcgg gagtatatga atgtgaatct aaaaacaaag ttggctcaca
1861 attaagaagt ttaacacttg atgttcaagg aagagaaaac aacaaagact atttttctcc
1921 tgagcttctc gtgctctatt ttgcatcctc cttaataata cctgccattg gaatgataat
1981 ttactttgca agaaaagcca acatgaaggg gtcatatagt cttgtagaag cacagaaatc
2041 aaaagtgtag ctaatgcttg atatgttcaa ctggagacac tatttatctg tgcaaatcct
2101 tgatactgct catcattcct tgagaaaaac aatgagctga gaggcagact tccctgaatg
2161 tattgaactt ggaaagaaat gcccatctat gtcccttgct gtgagcaaga agtcaaagta
2221 aaacttgctg cctgaagaac agtaactgcc atcaagatga gagaactgga ggagttcctt
2281 gatctgtata tacaataaca taatttgtac atatgtaaaa taaaattatg ccatagcaag
2341 attgcttaaa atagcaacac tctatattta gattgttaaa ataactagtg ttgcttggac
2401 tattataatt taatgcatgt taggaaaatt tcacattaat atttgctgac agctgacctt
2461 tgtcatcttt cttctatttt attccctttc acaaaatttt attcctatat agtttattga
2521 caataatttc aggttttgta aagatgccgg gttttatatt tttatagaca aataataagc
2581 aaagggagca ctgggttgac tttcaggtac taaatacctc aacctatggt ataatggttg
2641 actgggtttc tctgtatagt actggcatgg tacggagatg tttcacgaag tttgttcatc
2701 agactcctgt gcaactttcc caatgtggcc taaaaatgca acttcttttt attttctttt
2761 gtaaatgttt aggttttttt gtatagtaaa gtgataattt ctggaattaa a
//