LOCUS HUMCYP2BB 3045 bp mRNA linear HUM 02-NOV-1994
DEFINITION Human cytochrome P450-IIB (hIIB1) mRNA, complete cds.
ACCESSION M29874 J02864
VERSION M29874.1
KEYWORDS cytochrome P450; cytochrome P450 IIB.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3045)
AUTHORS Yamano,S., Nhamburo,P.T., Aoyama,T., Meyer,U.A., Inaba,T.,
Kalow,W., Gelboin,H.V., McBride,O.W. and Gonzalez,F.J.
TITLE cDNA cloning and sequence and cDNA-directed expression of human
P450 IIB1: identification of a normal and two variant cDNAs derived
from the CYP2B locus on chromosome 19 and differential expression
of the IIB mRNAs in human liver
JOURNAL Biochemistry 28 (18), 7340-7348 (1989)
PUBMED 2573390
COMMENT Original source text: Human liver, cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..3045
/db_xref="H-InvDB:HIT000195340"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="19q13.2"
gene 1..3045
/gene="CYP2B"
CDS 7..1482
/gene="CYP2B"
/note="cytochrome P450-IIB"
/codon_start=1
/protein_id="AAA52144.1"
/db_xref="GDB:G00-120-752"
/translation="MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLL
QMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIA
MVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKS
KGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFE
LFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEK
SNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP
HRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLIL
STALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFF
TTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR"
repeat_region 1716..1997
/gene="CYP2B"
/note="Alu repeat 1"
repeat_region 2134..2306
/gene="CYP2B"
/note="Alu repeat 2"
BASE COUNT 706 a 866 c 658 g 815 t
ORIGIN
1 cagaccatgg aactcagcgt cctcctcttc cttgcactcc tcacaggact cttgctactc
61 ctggttcagc gccaccctaa cacccatgac cgcctcccac cagggccccg ccctctgccc
121 cttttgggaa accttctgca gatggataga agaggcctac tcaaatcctt tctgaggttc
181 cgagagaaat atggggacgt cttcacggta cacctgggac cgaggcccgt ggtcatgctg
241 tgtggagtag aggccatacg ggaggccctt gtggacaagg ctgaggcctt ctctggccgg
301 ggaaaaatcg ccatggtcga cccattcttc cggggatatg gtgtgatctt tgccaatgga
361 aaccgctgga aggtgcttcg gcgattctct gtgaccacta tgagggactt cgggatggga
421 aagcggagtg tggaggagcg gattcaggag gaggctcagt gtctgataga ggagcttcgg
481 aaatccaagg gggccctcat ggaccccacc ttcctcttcc agtccattac cgccaacatc
541 atctgctcca tcgtctttgg aaaacgattc cactaccaag atcaagagtt cctgaagatg
601 ctgaacttgt tctaccagac tttttcactc atcagctctg tattcggcca gctgtttgag
661 ctcttctctg gcttcttgaa atactttcct ggggcacaca ggcaagttta caaaaacctg
721 caggaaatca atgcttacat tggccacagt gtggagaagc accgtgaaac cctggacccc
781 agcgccccca aggacctcat cgacacctac ctgctccaca tggaaaaaga gaaatccaac
841 gcacacagtg aattcagcca ccagaacctc aacctcaaca cgctctcgct cttctttgct
901 ggcactgaga ccaccagcac cactctccgc tacggcttcc tgctcatgct caaataccct
961 catgttgcag agagagtcta cagggagatt gaacaggtga ttggcccaca tcgccctcca
1021 gagcttcatg accgagccaa aatgccatac acagaggcag tcatctatga gattcagaga
1081 ttttccgacc ttctccccat gggtgtgccc cacattgtca cccaacacac cagcttccga
1141 gggtacatca tccccaagga cacagaagta tttctcatcc tgagcactgc tctccatgac
1201 ccacactact ttgaaaaacc agacgccttc aatcctgacc actttctgga tgccaatggg
1261 gcactgaaaa agactgaagc ttttatcccc ttctccttag ggaagcggat ttgtcttggt
1321 gaaggcatcg cccgtgcgga attgttcctc ttcttcacca ccatcctcca gaacttctcc
1381 atggccagcc ccgtggcccc agaagacatc gatctgacac cccaggagtg tggtgtgggc
1441 aaaatacccc caacatacca gatccgcttc ctgccccgct gaaggggctg agggaagggg
1501 gtcaaaggat tccagggtca ttcagtgtcc ccgcctctgt agacaatggc tctgactccc
1561 cgcaacttcc tgcctctgag agacctgcta caagccagct tccttcccct ccatggcacc
1621 agttgtctga ggtcacattg caagtgagtg caggagtgag attatcgaaa attataatat
1681 acaaaatcat atatatatat atgttcttgt tttttgagac agagtctcac actgttgccc
1741 aggctggagt gcagtggcgt gatcttggct cactgcaacc tccacccccg gggatcaagc
1801 aactctcctg cctcagcctc cctagaggct gggattacag gcatgcacta ccacgcttgg
1861 ctaatttttg tatttttagt agagatgggg tttcactgtg taggccaggc tggtctcgaa
1921 ctcctgaact caagtgattc acccacctta gcctcccaaa gtgctgggat tacaggcgtg
1981 agtcaccgtg cccagccatg tatatatata attttaaaaa ttaagctgaa attcacataa
2041 cataaaatta gccgttttaa agtgtaaaat ttagtggcgt gtggttcatt cacaaagctg
2101 tacaaccacc accatctagt tccaaacatt ttcttttttt ctgagatgga gtctcactct
2161 gtcacccagg ttcgagttca gtggtgccat ctctgtccac tgcaacctcc acatcctggg
2221 ttcaagtgat tctcctgcct cagcctctgg aggagctggt atcacaggcg tcccccacca
2281 cgcctggcta aattttgtat ttttaggtgg tcttgaactc ctgatgtcag gtgattctcc
2341 tagctccaaa tgttttcatt atctctcccc caacaaaacc catacctatc aagctgtcac
2401 tccccatacc ccattctctt tttcatctcg gcccctgtca atctggtttt tgtcactatg
2461 gacttaccaa ttctgaatat ttcccataaa cagaatcata caatatttga tttttttttt
2521 tttttgaaac taagccttgc tctgtctccc aggctggagt gctatggtgc aatttttgtt
2581 cactgcaacc tctgccttcc aagatcaaga gattctccag tctcagctcc caagtagctg
2641 ggattacagg catgtactac catgcctggc taattttctt gtagttttag tagggacatg
2701 ttggccaggc tggtggtgag ctcctggcct caggtgatcc acccacctca gtgttcctaa
2761 gtgctgatat tacaggcata atatgtgatc ttttgtgtct ggttgctttc atgttgaatg
2821 ctatttttga ggttcgtgcc tgttgtagac cacagtcaca cactgctgta gtcttcccga
2881 gtcctcattc ccagctgcct cttcctactg cttccgtcta tcaaaaagcc cccttggccc
2941 aggttccctg agctgtggga ttctgcactg gtgctttgga ttccctgata tgttccttca
3001 aatctgctga gaattaaata aacatctcta aagcctgacc tcccc
//