LOCUS AH007113 5716 bp DNA linear HUM 10-JUN-2016
DEFINITION Homo sapiens chromosome 14 IGH@ pseudogene, partial sequence; and
IGH@ (IGH@) gene, partial cds.
ACCESSION AH007113 M29809 M29810 M29811 M29812 M29813 M29814 M29815 X92324
VERSION AH007113.2
KEYWORDS C-region; V-region; germline; immunoglobulin heavy chain;
pseudogene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5716)
AUTHORS Kodaira,M., Kinashi,T., Umemura,I., Matsuda,F., Noma,T., Ono,Y. and
Honjo,T.
TITLE Organization and evolution of variable region genes of the human
immunoglobulin heavy chain
JOURNAL J. Mol. Biol. 190 (4), 529-541 (1986)
PUBMED 3097326
COMMENT On or before Jun 10, 2016 this sequence version replaced M29814.1,
M29811.1, M29813.1, M29812.1, M29809.1, M29815.1, M29810.1,
AH007113.1.
FEATURES Location/Qualifiers
source 1..5716
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q32.33"
/cell_type="peripheral blood cell"
/tissue_type="placenta"
/germline
gene 29..5716
/gene="IGH@"
CDS join(29..74,178..>407)
/gene="IGH@"
/pseudo
/codon_start=1
/db_xref="GDB:G00-118-731"
intron 75..177
/gene="IGH@"
/note="G00-118-731"
exon 178..407
/gene="IGH@"
/note="G00-118-731"
/number=2
iDNA 410..>485
/gene="IGH@"
/note="V-D intervening DNA; G00-118-731"
gap 486..585
/estimated_length=unknown
CDS join(<736..781,864..>1172)
/gene="IGH@"
/codon_start=1
/protein_id="AAC99493.1"
/db_xref="GDB:G00-118-731"
/translation="MKHLWFFLLLVAAPRWVLSQVQLQESGPGLVKPSETLSLTCTVS
GGSVSSGSYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLK
LSSVTAADTAVYYCAR"
sig_peptide join(736..781,864..874)
/gene="IGH@"
mat_peptide 875..1171
/gene="IGH@"
/product="Ig H-chain"
intron 782..863
/gene="IGH@"
/note="IgH, intron A; G00-118-731"
iDNA 1174..>1797
/gene="IGH@"
/note="V-D intervening DNA (5' end put.); G00-118-731;
putative"
gap 1798..1897
/estimated_length=unknown
CDS join(1955..2000,2103..>2409)
/gene="IGH@"
/pseudo
/codon_start=1
/db_xref="GDB:G00-118-731"
intron 2001..2102
/gene="IGH@"
/note="G00-118-731"
exon 2103..2409
/gene="IGH@"
/note="G00-118-731"
/number=2
exon 2103..2113
/gene="IGH@"
/note="pseudo-Ig H-chain signal peptide, exon 2; putative"
iDNA 2410..>2485
/gene="IGH@"
/note="V-D intervening DNA (5' end put.); G00-118-731;
putative"
gap 2486..2585
/estimated_length=unknown
CDS join(2736..2781,2864..>3166)
/gene="IGH@"
/codon_start=1
/protein_id="AAC99494.1"
/db_xref="GDB:G00-118-731"
/translation="MKHLWFFLLLVAAPRWVLSQVQLQESGPGLVKPSETLSLTCTVS
GGSVSSYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLS
SVTAADTAVYYCAR"
sig_peptide join(2736..2781,2864..2874)
/gene="IGH@"
mat_peptide 2875..>3166
/gene="IGH@"
/product="G00-118-731"
intron 2782..2863
/gene="IGH@"
/note="G00-118-731"
exon 2864..3166
/gene="IGH@"
/note="G00-118-731"
/number=2
iDNA 3168..>3784
/gene="IGH@"
/note="V-D intervening DNA (5' end put.); G00-118-731;
putative"
gap 3785..3884
/estimated_length=unknown
CDS join(4035..4080,4166..>4471)
/gene="IGH@"
/codon_start=1
/protein_id="AAC99495.1"
/db_xref="GDB:G00-118-731"
/translation="MDWIWRILFLVGAATGAHSQMQLVQSGPEVKKPGTSVKVSCKAS
GFTFTSSAVQWVRQARGQRLEWIGWIVVGSGNTNYAQKFQERVTITRDMSTSTAYMEL
SSLRSEDTAVYYCAA"
sig_peptide join(4035..4080,4166..4176)
/gene="IGH@"
intron 4081..4165
/gene="IGH@"
/note="G00-118-731; putative; does not fit consensus"
exon 4166..4471
/gene="IGH@"
/note="G00-118-731"
/number=2
iDNA 4473..>4513
/gene="IGH@"
/note="V-D intervening DNA (5' end put.); G00-118-731;
putative"
gap 4514..4613
/estimated_length=unknown
CDS join(4620..4665,4769..>5145)
/gene="IGH@"
/pseudo
/codon_start=1
/db_xref="GDB:G00-118-731"
intron 4666..4768
/gene="IGH@"
/note="G00-118-731; putative; does not fit consensus"
iDNA 5146..>5187
/gene="IGH@"
/note="V-D intervening DNA (5' end put.); G00-118-731;
putative"
gap 5188..5287
/estimated_length=unknown
CDS join(5423..5468,5552..>5716)
/gene="IGH@"
/pseudo
/codon_start=1
/db_xref="GDB:G00-118-731"
intron 5469..5551
/gene="IGH@"
/note="G00-118-731"
exon 5552..5716
/gene="IGH@"
/note="G00-118-731"
/number=2
BASE COUNT 1253 a 1262 c 1366 g 1235 t
ORIGIN
1 gatcagcact gaacacagag gactcaccat ggagtttggg ctgagctggg ttttccttgt
61 tgctatttta agaggtgatt catagataaa tagagatgtt gagtgggagt ggacatgagt
121 gagagaaaca gtggatgtgt gtggcagttt ctgaccttgg tgtctttgtg tttgcaggtg
181 tccagtgtga ggtgcagctg gtggagtctg gggaaggctt ggtccagcct ggggggtccc
241 tgagactctc ctgtgcagcc tctggattca ccttcagtag ctctgctatg cactgggtcc
301 gccaggctcc aagaaagggt ttgtagtggg tctcagttat tagtacaagt ggtgataccg
361 tactctacac agactctgtg aagggcgttg tgtactactg tgtgaaagac gcagtgagaa
421 gtcagtgtga gcccagacac aaacctcctg cagggtacct gggacaatca gggaaagcct
481 gggacnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnncctcc tttttcacct
601 ctccgtacaa aggcaccacc cacatgcaaa tccttactta agcacccaca ggaaaccacc
661 acacatttcc ttaaattcag gttccagctc acatgggaaa tactttctga gagcctggac
721 ctcctgtgca agaacatgaa acacctgtgg ttcttcctcc tcctggtggc agctcccaga
781 tgtgagtgtc tcagggatcc agacatgggg gtatgggagg tgcctctgat cccagggctc
841 actgtgggtc tctctgttca caggggtcct gtcccaggtg cagctgcagg agtcgggccc
901 aggactggtg aagccttcgg agaccctgtc cctcacctgc actgtctctg gtggctccgt
961 cagcagtggt agttactact ggagctggat ccggcagccc ccagggaagg gactggagtg
1021 gattgggtat atctattaca gtgggagcac caactacaac ccctccctca agagtcgagt
1081 caccatatca gtagacacgt ccaagaacca gttctccctg aagctgagct ctgtgaccgc
1141 tgcggacacg gccgtgtatt actgtgcgag agacacagtg aggggaggtg agtgtgagcc
1201 caggacacaa acctccctca tggacgcgga ggggaccggc gcaggtgctg ctcaggacca
1261 gcaggtggcg cgcggggccc ccagagcatg aggccgggtc aggacaggtg cagggagggc
1321 ttcctcatct gctcactggt ctccgtcctc gccagcacct cgctgtcacc agggctcctc
1381 tttctttatt atctgtggtt ctgcttcctc acattcttgt gccaggaaag aaacgaggaa
1441 gacgggtttt cgtctatagt tgaagctttt actaggatct tgcctacaag ttcctgcatg
1501 acccattata acttatcgat taaaaaatat atattctaat gcttctcacc atctcttgat
1561 ttgtatcatc aactgaattg taccctcttt gaaattcata tgatgaaacc ttaaattcaa
1621 tggatctata ttggaatttt aatgaaataa ttaaggttaa atgtggtcat aattgtaaga
1681 ccctaatgca atagacgtgt tgtctttata agaagaggaa gagacaccag agacctctca
1741 cttttcacgt gcaggcagag aagaggccat gtggagacat agtgcactag aaggtggnnn
1801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1861 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnccc gggattccca gctgtctcca
1921 cttggtcatg aacactgaac acagaagaca caccatggag tctgggctga gctggatttt
1981 ccttgttgca gttttaaaag gtgatttatg gagaatagac acactgagtg tgactggaca
2041 taagtgagag aaacagtgga tttgtgtggc agtttctgac cagggtgtct ccgtgtttgc
2101 aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttagtaa agactggggg
2161 gtctctgaga ctctcctgtg cagcctctgg attcaccttc agtagctctg ctatgcactg
2221 ggtccaccag gctccaggaa agggtttgga gtgggtctca gttattagta caagtggtga
2281 taccgtactc tacacagact ctgtgaaggg ctgattcacc atctctagag acaatgccca
2341 gaattcactg tatctgcaaa tgaacagcct gagagccgac gacatggctg tgtattactg
2401 tgtgaaagac gcagtgagaa gtcagtgtga gcccagacac aaacctcctg cagggtacct
2461 gggacaacca gggaaagcct gggacnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2581 nnnnncctcc tttttcacct ctccatacaa aggcaccacc cacatgcaaa tcctcactta
2641 agcacccaca ggaaaccacc acacatttcc ttaaattcag gttccagctc acatgggaaa
2701 tactttctga gagcctggac ctcctgtgca agaacatgaa acatctgtgg ttcttccttc
2761 tcctggtggc agctcccaga tgtgagtatc tcagggatcc agacatgggg atatgggagg
2821 tgcctctgat cccagggctc actgtgggtc tctctgttca caggggtcct gtcccaggtg
2881 cagctgcagg agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc
2941 actgtctctg gtggctccgt cagtagttac tactggagct ggatccggca gcccccaggg
3001 aagggactgg agtggattgg gtatatctat tacagtggga gcaccaacta caacccctcc
3061 ctcaagagtc gagtcaccat atcagtagac acgtccaaga accagttctc cctgaagctg
3121 agctctgtga ccgctgcgga cacggccgtg tattactgtg cgagagacac agtgagggga
3181 ggtgagtgtg agcccagaca aaaacctccg tcagggaggc ggaggggacc cgcaaggtgc
3241 tgctcagacc agcaggcgcg gggcccacag agcaggaggc ccggtcagga caggtgcagg
3301 gagggcgggg cttcctcatc tgctcagtgg tctccctcct cgccagcacc tcgctgtccc
3361 caggggtcct ctttctttat tatctgtggt tctgcttcct cacattcttg tgccaagaaa
3421 gaaatgagga agacaaattt tcgtctatag ttgaagtttc accaattact aggaactttc
3481 ctagaagttc ctgcatggcc cattatagct tacagattaa atatatatca agcttctcat
3541 ctcttgattg tgtcatcaac tgaattgtgc cctctttgaa attcatatgc agaaacctta
3601 aattcaattg atgtatattg gaattttaat gaaataatta aggttaaatg tggtcataag
3661 tgtaagactc taattcaaca gacgtgtcgt ctttataaga agaggaagag acaccagaga
3721 cctctcactt ttcacgtgca ggcagagaag aggccatgtg gagacatagt gcactggaag
3781 gtggnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnagggtc ttcagctatg
3901 aaatgctctg actcatgaat atgcaaataa cctgagatgc actgaggtaa atatggatat
3961 ttgtcagccc tgagagcatc atccagaaac cacatccctc cgctagagaa gccctgacgg
4021 cacagttcct cactatggac tggatttgga ggatcctctt cttggtggga gcagcgacag
4081 gcaaggagat gccaagtccc agtgatgagg aggggattga gtccagtcaa ggtggctttc
4141 atccactcct gtgttctctc cacaggtgcc cactcccaaa tgcagctggt gcagtctggg
4201 cctgaggtga agaagcctgg gacctcagtg aaggtctcct gcaaggcttc tggattcacc
4261 tttactagct ctgctgtgca gtgggtgcga caggctcgtg gacaacgcct tgagtggata
4321 ggatggatcg tcgttggcag tggtaacaca aactacgcac agaagttcca ggaaagagtc
4381 accattacca gggacatgtc cacaagcaca gcctacatgg agctgagcag cctgagatcc
4441 gaggacacgg ccgtgtatta ctgtgcggca gacacagtgt gaaaacccac atcctgagag
4501 tgtcagaaac gccnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
4561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnngatcagt
4621 tgcgctcagg agttttagaa cagcctggca acacatttag atctgggctt cccttctcat
4681 caccctcaat attagtgtcc cttgtgaatc aggtccagct gcggctgttc cacatggggc
4741 cgttcttcca tttcctcagt gtttgcagaa gtcctgtgtg aagtttattg atggagtcag
4801 aggcagaatt gtacagccca gtggttcact gagactctcc tgcaaagcct ctgatttcac
4861 ctttactggc tacagcatga gcttggtcca gcaggcttca tgacagggat tggtgtgggt
4921 ggaaacagtg agttcaagtg ggagttctca gagttactct ccatgagtac aaatacgatt
4981 caccatctcc agagacaatg cccagaattc actgtctctg caaatgaaca gcctgagagc
5041 cgagggcaca aattaacagt cccaagcgac accttttcat gtgcagtcta ccttacaatg
5101 accaacctga aagccaagga caaggctgtg tattactgtg agggacacag gaagaaatct
5161 gtgtgagccc agacacaaat ctctgggnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
5221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
5281 nnnnnnnagg aattgggcta ttcaatgcat ccttcgtgaa tatgcaaatc actaaggtta
5341 atacagatat ctctgtgccg tgagagcatc acccaacaac cacacccctc cttggagaat
5401 ccctagatca cagctcctca ccatggactg gacctggagc atcctcttct tggtggcagc
5461 agcaacaggt aaggactccc cagtcccagg gctgagggag aaaccaggcc agtcatgtga
5521 gacttcaccc actgctgtct cctctccaca ggtgcccact cccgagtgca gctggtgcag
5581 tctgggcctg aggtgaagca gcctggggcc tcggcgaagg tctcctgcaa ggtgtctggt
5641 taaactgtca tcacctatgg tatgaattgg atacgacaga ccccaggaca ggggcttgag
5701 tggatgggat ggatcc
//