LOCUS HUMDRD2A 2482 bp mRNA linear HUM 09-NOV-1994
DEFINITION Human dopamine D2 receptor (DRD2) mRNA, complete cds.
ACCESSION M29066
VERSION M29066.1
KEYWORDS dopamine D2 receptor; regulatory protein; transmembrane protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2482)
AUTHORS Grandy,D.K., Marchionni,M.A., Makam,H., Stofko,R.E., Alfano,M.,
Frothingham,L., Fischer,J.B., Burke-Howie,K.J., Bunzow,J.R.,
Server,A.C. and Civelli,O.
TITLE Cloning of the cDNA and gene for a human D2 dopamine receptor
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86 (24), 9762-9766 (1989)
PUBMED 2532362
COMMENT Original source text: Homo sapiens pituitary cDNA to mRNA.
Draft entry and computer-readable sequence for [1] kindly submitted
by D.K.Grandy, 13-OCT-1989.
FEATURES Location/Qualifiers
source 1..2482
/db_xref="H-InvDB:HIT000195302"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="11q22-q23"
/clone="hPitD2"
/tissue_type="pituitary"
gene 1..2482
/gene="DRD2"
mRNA <1..2482
/gene="DRD2"
/product="DRD2 mRNA"
exon <1..318
/gene="DRD2"
/note="dopamine D2 receptor"
/number=1
5'UTR <1..33
/gene="DRD2"
CDS 34..1365
/gene="DRD2"
/codon_start=1
/product="dopamine D2 receptor"
/protein_id="AAA52761.1"
/db_xref="GDB:G00-119-852"
/translation="MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLL
IAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKF
SRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVW
VLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRR
RRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRA
QELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDH
PKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFIT
HILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC"
exon 319..428
/gene="DRD2"
/note="dopamine D2 receptor"
/number=2
exon 429..565
/gene="DRD2"
/note="dopamine D2 receptor"
/number=3
exon 566..755
/gene="DRD2"
/note="dopamine D2 receptor"
exon 756..843
/gene="DRD2"
/note="dopamine D2 receptor"
/number=5
exon 844..1171
/gene="DRD2"
/note="dopamine D2 receptor"
/number=6
exon 1172..2482
/gene="DRD2"
/note="dopamine D2 receptor"
/number=7
3'UTR 1366..2482
/gene="DRD2"
regulatory 2458..2464
/regulatory_class="polyA_signal_sequence"
/gene="DRD2"
BASE COUNT 511 a 845 c 619 g 507 t
ORIGIN
1 agagcctggc cacccagtgg ctccaccgcc ctgatggatc cactgaatct gtcctggtat
61 gatgatgatc tggagaggca gaactggagc cggcccttca acgggtcaga cgggaaggcg
121 gacagacccc actacaacta ctatgccaca ctgctcaccc tgctcatcgc tgtcatcgtc
181 ttcggcaacg tgctggtgtg catggctgtg tcccgcgaga aggcgctgca gaccaccacc
241 aactacctga tcgtcagcct cgcagtggcc gacctcctcg tcgccacact ggtcatgccc
301 tgggttgtct acctggaggt ggtaggtgag tggaaattca gcaggattca ctgtgacatc
361 ttcgtcactc tggacgtcat gatgtgcacg gcgagcatcc tgaacttgtg tgccatcagc
421 atcgacaggt acacagctgt ggccatgccc atgctgtaca atacgcgcta cagctccaag
481 cgccgggtca ccgtcatgat ctccatcgtc tgggtcctgt ccttcaccat ctcctgccca
541 ctcctcttcg gactcaataa cgcagaccag aacgagtgca tcattgccaa cccggccttc
601 gtggtctact cctccatcgt ctccttctac gtgcccttca ttgtcaccct gctggtctac
661 atcaagatct acattgtcct ccgcagacgc cgcaagcgag tcaacaccaa acgcagcagc
721 cgagctttca gggcccacct gagggctcca ctaaagggca actgtactca ccccgaggac
781 atgaaactct gcaccgttat catgaagtct aatgggagtt tcccagtgaa caggcggaga
841 gtggaggctg cccggcgagc ccaggagctg gagatggaga tgctctccag caccagccca
901 cccgagagga cccggtacag ccccatccca cccagccacc accagctgac tctccccgac
961 ccgtcccacc atggtctcca cagcactccc gacagccccg ccaaaccaga gaagaatggg
1021 catgccaaag accaccccaa gattgccaag atctttgaga tccagaccat gcccaatggc
1081 aaaacccgga cctccctcaa gaccatgagc cgtaggaagc tctcccagca gaaggagaag
1141 aaagccactc agatgctcgc cattgttctc ggcgtgttca tcatctgctg gctgcccttc
1201 ttcatcacac acatcctgaa catacactgt gactgcaaca tcccgcctgt cctgtacagc
1261 gccttcacgt ggctgggcta tgtcaacagc gccgtgaacc ccatcatcta caccaccttc
1321 aacattgagt tccgcaaggc cttcctgaag atcctccact gctgactctg ctgcctgccc
1381 gcacagcagc ctgcttccca cctccctgcc caggccggcc agcctcaccc ttgcgaaccg
1441 tgagcaggaa ggcctgggtg gatcggcctc ctcttcttag ccccggcagg ccctgcagtg
1501 ttcgcttggc tccatgctcc tcactgcccg cacaccctca ctctgccagg gcagtgctag
1561 tgagctgggc atggtaccag ccctggggct ggccccagct caggggcagc tcatagagtc
1621 ccccctccca cctccagtcc ccctatcctt ggcaccaaag atgcagccgc cttccttgac
1681 cttcctctgg ggctctaggg ttgctggagc ctgagtcagg gcccagaggc tgagttttct
1741 ctttgtgggg cttggcgtgg agcaggcggt ggggagagat ggacagttca caccctgcaa
1801 ggcccacagg aggcaagcaa gctctcttgc cgaggagcca ggcaacttca gtcctgggag
1861 acccatgtaa ataccagact gcaggttgga cccgagagat tcccaagcca aaaaccttag
1921 ctccctcccg caccccgatg tggacctcta ctttccaggc tagtccggac ccacctcacc
1981 ccgttacagc tccccaagtg gtttccacat gctctgagaa gaggagccct catcttgaag
2041 ggcccaggag ggtctatggg gagaggaact ccttggccta gcccaccctg ctgccttctg
2101 acggccctgc aatgtatccc ttctcacagc acatgctggc cagcctgggg cctggcaggg
2161 aggtcaggcc ctggaactct atctgggcct gggctaggga catcagaggt tctttgaggg
2221 actgcctctg ccacactctg acgcaaaacc actttccttt tctattcctt ctggcctttc
2281 ctctctcctg tttcccttcc cttccactgc ctctgcctta gaggagccca cggctaagag
2341 gctgctgaaa accatctggc ctggcctggc cctgccctga ggaaggaggg gaagctgcag
2401 cttgggagag cccctggggc ctagactctg taacatcact atccgatgca ccaaactaat
2461 aaaactttga cgagtcacct tc
//