LOCUS HUMRBSA 2994 bp mRNA linear HUM 12-JUL-1995 DEFINITION Human retinoblastoma susceptibility protein mRNA, complete cds. ACCESSION M28419 VERSION M28419.1 KEYWORDS retinoblastoma protein; retinoblastoma susceptibility protein. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2994) AUTHORS Lee,W.H., Shew,J.Y., Hong,F.D., Sery,T.W., Donoso,L.A., Young,L.J., Bookstein,R. and Lee,E.Y. TITLE The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity JOURNAL Nature 329 (6140), 642-645 (1987) PUBMED 3657987 COMMENT Original source text: Homo sapiens retinoblastoma cDNA to mRNA. FEATURES Location/Qualifiers source 1..2994 /db_xref="H-InvDB:HIT000195238" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="Xp22.32;Yp11.3" /cell_line="retinoblastoma cell line Y79, and normal retinoblastoma cell line" /tissue_type="retinoblastoma" gene 1..2994 /gene="MIC2" CDS 139..2925 /gene="MIC2" /note="retinoblastoma suceptibility protein" /codon_start=1 /protein_id="AAA69808.1" /db_xref="GDB:G00-120-184" /translation="MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPL VRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGIC IFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFA LFSKLERTCELIYLTQPSSSISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQL MLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEV LCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDAR LFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVNVIPPHTPVRTVMNTIQQLMMILNSA SDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGV RLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDS GTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTREMIKHLERCEHRIMESLAWLSD SPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNS TANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWT LFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFK RVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLR IPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSD RVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTSTRTRMQKQ KMNDSMDTSNKEEK" BASE COUNT 974 a 618 c 593 g 809 t ORIGIN 1 ttccggtttt tctcagggga cgttgaaatt atttttgtaa cgggagtcgg gagaggacgg 61 ggcgtgcccc gcgtgcgcgc gcgtcgtcct ccccggcgct cctccacagc tcgctggctc 121 ccgccgcgga aaggcgtcat gccgcccaaa accccccgaa aaacggccgc caccgccgcc 181 gctgccgccg cggaaccccc ggcaccgccg ccgccgcccc ctcctgagga ggacccagag 241 caggacagcg gcccggagga cctgcctctc gtcaggcttg agtttgaaga aacagaagaa 301 cctgatttta ctgcattatg tcagaaatta aagataccag atcatgtcag agagagagct 361 tggttaactt gggagaaagt ttcatctgtg gatggagtat tgggaggtta tattcaaaag 421 aaaaaggaac tgtggggaat ctgtatcttt attgcagcag ttgacctaga tgagatgtcg 481 ttcactttta ctgagctaca gaaaaacata gaaatcagtg tccataaatt ctttaactta 541 ctaaaagaaa ttgataccag taccaaagtt gataatgcta tgtcaagact gttgaagaag 601 tatgatgtat tgtttgcact cttcagcaaa ttggaaagga catgtgaact tatatatttg 661 acacaaccca gcagttcgat atctactgaa ataaattctg cattggtgct aaaagtttct 721 tggatcacat ttttattagc taaaggggaa gtattacaaa tggaagatga tctggtgatt 781 tcatttcagt taatgctatg tgtccttgac tattttatta aactctcacc tcccatgttg 841 ctcaaagaac catataaaac agctgttata cccattaatg gttcacctcg aacacccagg 901 cgaggtcaga acaggagtgc acggatagca aaacaactag aaaatgatac aagaattatt 961 gaagttctct gtaaagaaca tgaatgtaat atagatgagg tgaaaaatgt ttatttcaaa 1021 aattttatac cttttatgaa ttctcttgga cttgtaacat ctaatggact tccagaggtt 1081 gaaaatcttt ctaaacgata cgaagaaatt tatcttaaaa ataaagatct agatgcaaga 1141 ttatttttgg atcatgataa aactcttcag actgattcta tagacagttt tgaaacacag 1201 agaacaccac gaaaaagtaa ccttgatgaa gaggtgaatg taattcctcc acacactcca 1261 gttaggactg ttatgaacac tatccaacaa ttaatgatga ttttaaattc agcaagtgat 1321 caaccttcag aaaatctgat ttcctatttt aacaactgca cagtgaatcc aaaagaaagt 1381 atactgaaaa gagtgaagga tataggatac atctttaaag agaaatttgc taaagctgtg 1441 ggacagggtt gtgtcgaaat tggatcacag cgatacaaac ttggagttcg cttgtattac 1501 cgagtaatgg aatccatgct taaatcagaa gaagaacgat tatccattca aaattttagc 1561 aaacttctga atgacaacat ttttcatatg tctttattgg cgtgcgctct tgaggttgta 1621 atggccacat atagcagaag tacatctcag aatcttgatt ctggaacaga tttgtctttc 1681 ccatggattc tgaatgtgct taatttaaaa gcctttgatt tttacaaagt gatcgaaagt 1741 tttatcaaag cagaaggcaa cttgacaaga gaaatgataa aacatttaga acgatgtgaa 1801 catcgaatca tggaatccct tgcatggctc tcagattcac ctttatttga tcttattaaa 1861 caatcaaagg accgagaagg accaactgat caccttgaat ctgcttgtcc tcttaatctt 1921 cctctccaga ataatcacac tgcagcagat atgtatcttt ctcctgtaag atctccaaag 1981 aaaaaaggtt caactacgcg tgtaaattct actgcaaatg cagagacaca agcaacctca 2041 gccttccaga cccagaagcc attgaaatct acctctcttt cactgtttta taaaaaagtg 2101 tatcggctag cctatctccg gctaaataca ctttgtgaac gccttctgtc tgagcaccca 2161 gaattagaac atatcatctg gacccttttc cagcacaccc tgcagaatga gtatgaactc 2221 atgagagaca ggcatttgga ccaaattatg atgtgttcca tgtatggcat atgcaaagtg 2281 aagaatatag accttaaatt caaaatcatt gtaacagcat acaaggatct tcctcatgct 2341 gttcaggaga cattcaaacg tgttttgatc aaagaagagg agtatgattc tattatagta 2401 ttctataact cggtcttcat gcagagactg aaaacaaata ttttgcagta tgcttccacc 2461 aggcccccta ccttgtcacc aatacctcac attcctcgaa gcccttacaa gtttcctagt 2521 tcacccttac ggattcctgg agggaacatc tatatttcac ccctgaagag tccatataaa 2581 atttcagaag gtctgccaac accaacaaaa atgactccaa gatcaagaat cttagtatca 2641 attggtgaat cattcgggac ttctgagaag ttccagaaaa taaatcagat ggtatgtaac 2701 agcgaccgtg tgctcaaaag aagtgctgaa ggaagcaacc ctcctaaacc actgaaaaaa 2761 ctacgctttg atattgaagg atcagatgaa gcagatggaa gtaaacatct cccaggagag 2821 tccaaatttc agcagaaact ggcagaaatg acttctactc gaacacgaat gcaaaagcag 2881 aaaatgaatg atagcatgga tacctcaaac aaggaagaga aatgaggatc tcaggacctt 2941 ggtggacact gtgtacacct ctggattcat tgtctctcac agatgtgact gtat //