LOCUS       HUMRBSA                 2994 bp    mRNA    linear   HUM 12-JUL-1995
DEFINITION  Human retinoblastoma susceptibility protein mRNA, complete cds.
ACCESSION   M28419
VERSION     M28419.1
KEYWORDS    retinoblastoma protein; retinoblastoma susceptibility protein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2994)
  AUTHORS   Lee,W.H., Shew,J.Y., Hong,F.D., Sery,T.W., Donoso,L.A., Young,L.J.,
            Bookstein,R. and Lee,E.Y.
  TITLE     The retinoblastoma susceptibility gene encodes a nuclear
            phosphoprotein associated with DNA binding activity
  JOURNAL   Nature 329 (6140), 642-645 (1987)
   PUBMED   3657987
COMMENT     Original source text: Homo sapiens retinoblastoma cDNA to mRNA.
FEATURES             Location/Qualifiers
     source          1..2994
                     /db_xref="H-InvDB:HIT000195238"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="Xp22.32;Yp11.3"
                     /cell_line="retinoblastoma cell line Y79, and normal
                     retinoblastoma cell line"
                     /tissue_type="retinoblastoma"
     gene            1..2994
                     /gene="MIC2"
     CDS             139..2925
                     /gene="MIC2"
                     /note="retinoblastoma suceptibility protein"
                     /codon_start=1
                     /protein_id="AAA69808.1"
                     /db_xref="GDB:G00-120-184"
                     /translation="MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPL
                     VRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGIC
                     IFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFA
                     LFSKLERTCELIYLTQPSSSISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQL
                     MLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEV
                     LCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDAR
                     LFLDHDKTLQTDSIDSFETQRTPRKSNLDEEVNVIPPHTPVRTVMNTIQQLMMILNSA
                     SDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGV
                     RLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDS
                     GTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTREMIKHLERCEHRIMESLAWLSD
                     SPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNS
                     TANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWT
                     LFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFK
                     RVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLR
                     IPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSD
                     RVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTSTRTRMQKQ
                     KMNDSMDTSNKEEK"
BASE COUNT          974 a          618 c          593 g          809 t
ORIGIN      
        1 ttccggtttt tctcagggga cgttgaaatt atttttgtaa cgggagtcgg gagaggacgg
       61 ggcgtgcccc gcgtgcgcgc gcgtcgtcct ccccggcgct cctccacagc tcgctggctc
      121 ccgccgcgga aaggcgtcat gccgcccaaa accccccgaa aaacggccgc caccgccgcc
      181 gctgccgccg cggaaccccc ggcaccgccg ccgccgcccc ctcctgagga ggacccagag
      241 caggacagcg gcccggagga cctgcctctc gtcaggcttg agtttgaaga aacagaagaa
      301 cctgatttta ctgcattatg tcagaaatta aagataccag atcatgtcag agagagagct
      361 tggttaactt gggagaaagt ttcatctgtg gatggagtat tgggaggtta tattcaaaag
      421 aaaaaggaac tgtggggaat ctgtatcttt attgcagcag ttgacctaga tgagatgtcg
      481 ttcactttta ctgagctaca gaaaaacata gaaatcagtg tccataaatt ctttaactta
      541 ctaaaagaaa ttgataccag taccaaagtt gataatgcta tgtcaagact gttgaagaag
      601 tatgatgtat tgtttgcact cttcagcaaa ttggaaagga catgtgaact tatatatttg
      661 acacaaccca gcagttcgat atctactgaa ataaattctg cattggtgct aaaagtttct
      721 tggatcacat ttttattagc taaaggggaa gtattacaaa tggaagatga tctggtgatt
      781 tcatttcagt taatgctatg tgtccttgac tattttatta aactctcacc tcccatgttg
      841 ctcaaagaac catataaaac agctgttata cccattaatg gttcacctcg aacacccagg
      901 cgaggtcaga acaggagtgc acggatagca aaacaactag aaaatgatac aagaattatt
      961 gaagttctct gtaaagaaca tgaatgtaat atagatgagg tgaaaaatgt ttatttcaaa
     1021 aattttatac cttttatgaa ttctcttgga cttgtaacat ctaatggact tccagaggtt
     1081 gaaaatcttt ctaaacgata cgaagaaatt tatcttaaaa ataaagatct agatgcaaga
     1141 ttatttttgg atcatgataa aactcttcag actgattcta tagacagttt tgaaacacag
     1201 agaacaccac gaaaaagtaa ccttgatgaa gaggtgaatg taattcctcc acacactcca
     1261 gttaggactg ttatgaacac tatccaacaa ttaatgatga ttttaaattc agcaagtgat
     1321 caaccttcag aaaatctgat ttcctatttt aacaactgca cagtgaatcc aaaagaaagt
     1381 atactgaaaa gagtgaagga tataggatac atctttaaag agaaatttgc taaagctgtg
     1441 ggacagggtt gtgtcgaaat tggatcacag cgatacaaac ttggagttcg cttgtattac
     1501 cgagtaatgg aatccatgct taaatcagaa gaagaacgat tatccattca aaattttagc
     1561 aaacttctga atgacaacat ttttcatatg tctttattgg cgtgcgctct tgaggttgta
     1621 atggccacat atagcagaag tacatctcag aatcttgatt ctggaacaga tttgtctttc
     1681 ccatggattc tgaatgtgct taatttaaaa gcctttgatt tttacaaagt gatcgaaagt
     1741 tttatcaaag cagaaggcaa cttgacaaga gaaatgataa aacatttaga acgatgtgaa
     1801 catcgaatca tggaatccct tgcatggctc tcagattcac ctttatttga tcttattaaa
     1861 caatcaaagg accgagaagg accaactgat caccttgaat ctgcttgtcc tcttaatctt
     1921 cctctccaga ataatcacac tgcagcagat atgtatcttt ctcctgtaag atctccaaag
     1981 aaaaaaggtt caactacgcg tgtaaattct actgcaaatg cagagacaca agcaacctca
     2041 gccttccaga cccagaagcc attgaaatct acctctcttt cactgtttta taaaaaagtg
     2101 tatcggctag cctatctccg gctaaataca ctttgtgaac gccttctgtc tgagcaccca
     2161 gaattagaac atatcatctg gacccttttc cagcacaccc tgcagaatga gtatgaactc
     2221 atgagagaca ggcatttgga ccaaattatg atgtgttcca tgtatggcat atgcaaagtg
     2281 aagaatatag accttaaatt caaaatcatt gtaacagcat acaaggatct tcctcatgct
     2341 gttcaggaga cattcaaacg tgttttgatc aaagaagagg agtatgattc tattatagta
     2401 ttctataact cggtcttcat gcagagactg aaaacaaata ttttgcagta tgcttccacc
     2461 aggcccccta ccttgtcacc aatacctcac attcctcgaa gcccttacaa gtttcctagt
     2521 tcacccttac ggattcctgg agggaacatc tatatttcac ccctgaagag tccatataaa
     2581 atttcagaag gtctgccaac accaacaaaa atgactccaa gatcaagaat cttagtatca
     2641 attggtgaat cattcgggac ttctgagaag ttccagaaaa taaatcagat ggtatgtaac
     2701 agcgaccgtg tgctcaaaag aagtgctgaa ggaagcaacc ctcctaaacc actgaaaaaa
     2761 ctacgctttg atattgaagg atcagatgaa gcagatggaa gtaaacatct cccaggagag
     2821 tccaaatttc agcagaaact ggcagaaatg acttctactc gaacacgaat gcaaaagcag
     2881 aaaatgaatg atagcatgga tacctcaaac aaggaagaga aatgaggatc tcaggacctt
     2941 ggtggacact gtgtacacct ctggattcat tgtctctcac agatgtgact gtat
//