LOCUS HUMCREB 2454 bp mRNA linear HUM 27-APR-1993
DEFINITION Human transactivator protein (CREB) mRNA, complete cds.
ACCESSION M27691
VERSION M27691.1
KEYWORDS transactivator.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (sites)
AUTHORS Hoeffler,J.P., Meyer,T.E., Yun,Y., Jameson,J.L. and Habener,J.F.
TITLE Cyclic AMP-responsive DNA-binding protein: structure based on a
cloned placental cDNA
JOURNAL Science 242 (4884), 1430-1433 (1988)
PUBMED 2974179
REFERENCE 2 (bases 1 to 2454)
AUTHORS Hoeffler,J.P., Lee,C.Q., Waeber,G., Habener,J.F. and Meyer,T.E.
TITLE Cyclic AMP-stimulated gene transcription by the cellular expression
of cDNA-encoded transactivator protein CREB
JOURNAL Unpublished
REFERENCE 3 (sites)
AUTHORS Meyer,T.E. and Habener,J.F.
TITLE Cyclic AMP response element binding protein CREB and modulator
protein CREM are products of distinct genes
JOURNAL Nucleic Acids Res. 20 (22), 6106 (1992)
PUBMED 1461747
COMMENT Original source text: Human placenta, cDNA to mRNA, clone
hpG1CREBZ.
[1] sites; amino acid sequence.
Draft entry and computer-readable sequence for [1] kindly submitted
by T.E.Meyer, 07-SEP-1989.
FEATURES Location/Qualifiers
source 1..2454
/db_xref="H-InvDB:HIT000195183"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 117..1100
/note="transactivator protein"
/codon_start=1
/protein_id="AAA35715.1"
/translation="MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAA
HATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVD
SVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPI
YQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQ
ILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRL
MKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD"
BASE COUNT 801 a 473 c 485 g 695 t
ORIGIN
1 cgcggcggag gtgtagtttg acgcggtgtg ttacgtgggg gagagaataa aactccagcg
61 agatccgggc cgtgaacgaa agcagtgacg gaggagcttg taccaccggt aactaaatga
121 ccatggaatc tggagccgag aaccagcaga gtggagatgc agctgtaaca gaagctgaaa
181 accaacaaat gacagttcaa gcccagccac agattgccac attagcccag gtatctatgc
241 cagcagctca tgcaacatca tctgctccca ccgtaactct agtacagctg cccaatgggc
301 agacagttca agtccatgga gtcattcagg cggcccagcc atcagttatt cagtctccac
361 aagtccaaac agttcagatt tcaactattg cagaaagtga agattcacag gagtcagtgg
421 atagtgtaac tgattcccaa aagcgaaggg aaattctttc aaggaggcct tcctacagga
481 aaattttgaa tgacttatct tctgatgcac caggagtgcc aaggattgaa gaagagaagt
541 ctgaagagga gacttcagca cctgccatca ccactgtaac ggtgccaact ccaatttacc
601 aaactagcag tggacagtat attgccatta cccagggagg agcaatacag ctggctaaca
661 atggtaccga tggggtacag ggcctgcaaa cattaaccat gaccaatgca gcagccactc
721 agccgggtac taccattcta cagtatgcac agaccactga tggacagcag atcttagtgc
781 ccagcaacca agttgttgtt caagctgcct ctggagacgt acaaacatac cagattcgca
841 cagcacccac tagcactatt gcccctggag ttgttatggc atcctcccca gcacttccta
901 cacagcctgc tgaagaagca gcacgaaaga gagaggtccg tctaatgaag aacagggaag
961 cagctcgaga gtgtcgtaga aagaagaaag aatatgtgaa atgtttagaa aacagagtgg
1021 cagtgcttga aaatcaaaac aagacattga ttgaggagct aaaagcactt aaggaccttt
1081 actgccacaa atcagattaa tttgggattt aaattttcac ctgttaaggt ggaaaatgga
1141 ctggcttggc cacaacctga aagacaaaat aaacatttta ttttctaaac atttcttttt
1201 ttctatgcgc aaaactgcct gaaagcaact acagaatttc attcatttgt gcttttgcat
1261 taaactgtga atgttccaac acctgcctcc acttctcccc tcaagaaatt ttcaacgcca
1321 ggaatcatga agagacttct gcttttcaac ccccaccctc ctcaagaagt aataatttgt
1381 ttacttgtaa attgatggga gaaatgagga aaagaaaatc tttttaaaaa tgatttcaag
1441 gtttgtgctg agctccttga ttgccttagg gacagaatta ccccagcctc ttgagctgaa
1501 gtaatgtgtg ggccgcatgc ataaagtaag taaggtgcaa tgaagaagtg ttgattgcca
1561 aattgacatg ttgtcacatt ctcattgtga attatgtaaa gttgttaaga gacataccct
1621 ctaaaaaaga actttagcat ggtattgaag gaattagaaa tgaatttgga gtgcttttta
1681 tgtatgttgt cttcttcaat actgaaaatt tgtccttggt tcttaaaagc attctgtact
1741 aatacagctc ttccataggg cagttgttgc ttcttaattc agttctgtat gtgttcaaca
1801 tttttgaata cattaaaaga agtaaccaac tgaacgacaa agcatggtat ttgaatttta
1861 aattaaagca aagtaaataa aagtacaaag catattttag ttagtactaa attcttagta
1921 aaatgctgat cagtaaacca atcccttgag ttatataaca agatttttaa ataaatgtta
1981 ttgtcctcac cttcaaaaat atttatattg tcactcattt acgtaaaaag atatttctaa
2041 tttactgttg cccattgcac ttacatacca ccaccaagaa agccttcaag atgtcaaata
2101 aagcaaagtg atatatattt gtttatgaaa tgttacatgt agaaaaatac tgattttaaa
2161 tattttccat attaacaatt taacagagaa tctctagtga attttttaaa tgaaagaagt
2221 tgtaaggata taaaaagtac agtgttagat gtgcacaagg aaagttattt tcagacatat
2281 ttgaatgact gctgtactgc aatatttgga ttgtcattct tacaaaacat ttttttgttc
2341 tcttgtaaaa agagtagtta ttagttctgc tttagctttc caatatgctg tatagccttt
2401 gtcattttat aattttaatt cctgattaaa acagtctgta tttgtgtata tcat
//