LOCUS HUMTOPIIX 2685 bp mRNA linear HUM 14-JAN-1995
DEFINITION Homo sapiens topoisomerase type II (Topo II) mRNA, partial cds.
ACCESSION M27504
VERSION M27504.1
KEYWORDS topoisomerase II.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2685)
AUTHORS Chung,T.D., Drake,F.H., Tan,K.B., Per,S.R., Crooke,S.T. and
Mirabelli,C.K.
TITLE Characterization and immunological identification of cDNA clones
encoding two human DNA topoisomerase II isozymes
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86 (23), 9431-9435 (1989)
PUBMED 2556712
COMMENT Original source text: Human Burkitt lymphoma cell line Raji-HN2,
cDNA to mRNA, clone SP11.
Computer readable copy of sequence [1] kindly submitted by
Chung,T.D.Y., 01-SEP-1989.
FEATURES Location/Qualifiers
source 1..2685
/db_xref="H-InvDB:HIT000195167"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="17q21-q22"
gene 1..2685
/gene="TOP2A"
CDS <1..>2658
/gene="TOP2A"
/note="topoisomerase II"
/codon_start=1
/protein_id="AAA61210.1"
/db_xref="GDB:G00-118-884"
/translation="VEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCN
IFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKME
KLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALK
VIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKN
KAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAAS
NCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTE
GDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK
KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPI
VKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHR
ILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHL
TYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSV
AEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTM
LSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNY
DAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITE
LPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAA
GLHKVFKLQTTLTCNSMVLFDHMGCLKKYE"
BASE COUNT 910 a 426 c 575 g 774 t
ORIGIN
1 gtagaacaca aggtggagaa agtttatgtt cctgctttaa tttttggaca gcttttaaca
61 tccagtaact atgatgatga tgagaaaaaa gttacaggtg gtcgtaatgg ttatggtgca
121 aaactttgta atattttcag tacaaagttt acagtagaaa cagcttgcaa agaatacaaa
181 cacagtttta agcagacatg gatgaataat atgatgaaga cttctgaagc caaaattaaa
241 cattttgatg gtgaagatta cacatgcata acattccaac cagatctgtc caaatttaag
301 atggaaaaac ttgacaagga tattgtggcc ctcatgacta gaagggcata tgatttggct
361 ggttcgtgta gaggggtcaa ggtcatgttt aatggaaaga aattgcctgt aaatggattt
421 cgcagttatg tagatcttta tgtgaaagac aaattggatg aaactggggt ggccctgaaa
481 gttattcatg agcttgcaaa tgaaagatgg gatgtttgtc tcacattgag tgaaaaagga
541 ttccagcaaa tcagctttgt aaatagtatt gcaactacaa aaggtggacg gcacgtggat
601 tatgtggtag atcaagttgt tggtaaactg attgaagtag ttaagaaaaa gaacaaagct
661 ggtgtatcag tgaaaccatt tcaagtaaaa aaccatatat gggtttttat taattgcctt
721 attgaaaatc caacttttga ttctcagact aaggaaaaca tgactctgca gcccaaaagt
781 tttgggtcta aatgccagct gtcagaaaaa ttttttaaag cagcctctaa ttgtggcatt
841 gtagaaagta tcctgaactg ggtgaaattt aaggctcaga ctcagctgaa taagaagtgt
901 tcatcagtaa aatacagtaa aatcaaaggt attcccaaac tggatgatgc taatgatgct
961 ggtggtaaac attccctgga gtgtacactg atattaacag agggagactc tgccaaatca
1021 ctggctgtgt ctggattagg tgtgattgga cgagacagat acggagtttt tccactcagg
1081 ggcaaaattc ttaatgtacg ggaagcttct cataaacaga tcatggaaaa tgctgaaata
1141 aataatatta ttaaaatagt tggtctacaa tataagaaaa gttacgatga tgcagaatct
1201 ctgaaaacct tacgctatgg aaagattatg attatgaccg atcaggatca agatggttct
1261 cacataaaag gcctgcttat taatttcatc catcacaatt ggccatcact tttgaagcat
1321 ggttttcttg aagagttcat tactcctatt gtaaaggcaa gcaaaaataa gcaggaactt
1381 tccttctaca gtattcctga atttgacgaa tggaaaaaac atatagaaaa ccagaaagcc
1441 tggaaaataa agtactataa aggattgggt actagtacag ctaaagaagc aaaggaatat
1501 tttgctgata tggaaaggca tcgcatcttg tttagatatg ctggtcctga agatgatgct
1561 gccattacct tggcatttag taagaagaag attgatgaca gaaaagaatg gttaacaaat
1621 tttatggaag accggagaca gcgtaggcta catggcttac cagagcaatt tttatatggt
1681 actgcaacaa agcatttgac ttataatgat ttcatcaaca aggaattgat tctcttctca
1741 aactcagaca atgaaagatc tataccatct cttgttgatg gctttaaacc tggccagcgg
1801 aaagttttat ttacctgttt caagaggaat gataaacgtg aagtaaaagt tgcccagttg
1861 gctggctctg ttgctgagat gtcggcttat catcatggag aacaagcatt gatgatgact
1921 attgtgaatt tggctcagaa ctttgtggga agtaacaaca ttaacttgct tcagcctatt
1981 ggtcagtttg gaactcggct tcatggtggc aaagatgctg caagccctcg ttatattttc
2041 acaatgttaa gcactttagc aaggctactt tttcctgctg tggatgacaa cctccttaag
2101 ttcctttatg atgataatca acgtgtagag cctgagtggt atattcctat aattcccatg
2161 gttttaataa atggtgctga gggcattggt actggatggg cttgtaaact acccaactat
2221 gatgctaggg aaattgtgaa caatgtcaga cgaatgctag atggcctgga tcctcatccc
2281 atgcttccaa actacaaaaa ctttaaaggc acgattcaag aacttggtca aaaccagtat
2341 gcagtcagtg gtgaaatatt tgtagtggac agaaacacag tagaaattac agagcttcca
2401 gttagaactt ggacacaggt atataaagaa caggttttag aacctatgct aaatggaaca
2461 gataaaacac cagcattaat ttctgattat aaagaatatc atactgacac aactgtgaaa
2521 tttgtggtga aaatgactga agagaaacta gcacaagcag aagctgctgg actgcataaa
2581 gtttttaaac ttcaaactac tcttacttgt aattccatgg tactttttga tcatatggga
2641 tgtctgaaga aatatgaaac tgtgcaagac attctgaaag aattc
//