LOCUS HUMVPF 1195 bp mRNA linear HUM 03-AUG-1993
DEFINITION Human vascular permeability factor mRNA, complete cds.
ACCESSION M27281 X15997
VERSION M27281.1
KEYWORDS endothelial cell mitogen; vascular permeability factor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1195)
AUTHORS Keck,P.J., Hauser,S.D., Krivi,G., Sanzo,K., Warren,T., Feder,J. and
Connolly,D.T.
TITLE Vascular permeability factor, an endothelial cell mitogen related
to PDGF
JOURNAL Science 246 (4935), 1309-1312 (1989)
PUBMED 2479987
COMMENT Original source text: Human histiocytic lymphoma cell line U937,
cDNA to mRNA, (library of Clontech), clone hVPF4.
Draft entry and computer-readable sequence for [1] kindly submitted
by P.J.Keck, 22-AUG-1989.
FEATURES Location/Qualifiers
source 1..1195
/db_xref="H-InvDB:HIT000195115"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 157..804
/note="vascular permeability factor precursor"
/codon_start=1
/protein_id="AAA36807.1"
/translation="MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFM
DVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNI
TMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRY
KSWSVPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR"
sig_peptide 157..234
/note="vascular permeability factor signal peptide"
mat_peptide 235..801
/product="vascular permeability factor"
BASE COUNT 324 a 318 c 330 g 223 t
ORIGIN
1 gcgcagacag tgctccagcg cgcgcgctcc ccagccctgc ccggcctcgg gccgggagga
61 agagtagctc gccgaggcgc cgaggagagc gggccgcccc acagcccgag ccggagaggg
121 acgcgagccg cgcgccccgg tcgggcctcc gaaaccatga actttctgct gtcttgggtg
181 cattggagcc ttgccttgct gctctacctc caccatgcca agtggtccca ggctgcaccc
241 atggcagaag gaggagggca gaatcatcac gaagtggtga agttcatgga tgtctatcag
301 cgcagctact gccatccaat cgagaccctg gtggacatct tccaggagta ccctgatgag
361 atcgagtaca tcttcaagcc atcctgtgtg cccctgatgc gatgcggggg ctgctgcaat
421 gacgagggcc tggagtgtgt gcccactgag gagtccaaca tcaccatgca gattatgcgg
481 atcaaacctc accaaggcca gcacatagga gagatgagct tcctacagca caacaaatgt
541 gaatgcagac caaagaaaga tagagcaaga caagaaaaaa aatcagttcg aggaaaggga
601 aaggggcaaa aacgaaagcg caagaaatcc cggtataagt cctggagcgt tccctgtggg
661 ccttgctcag agcggagaaa gcatttgttt gtacaagatc cgcagacgtg taaatgttcc
721 tgcaaaaaca cagactcgcg ttgcaaggcg aggcagcttg agttaaacga acgtacttgc
781 agatgtgaca agccgaggcg gtgagccggg caggaggaag gagcctccct cagggtttcg
841 ggaaccagat ctctcaccag gaaagactga tacagaacga tcgatacaga aaccacgctg
901 ccgccaccac accatcacca tcgacagaac agtccttaat ccagaaacct gaaatgaagg
961 aagaggagac tctgcgcaga gcactttggg tccggagggc gagactccgg cggaagcatt
1021 cccgggcggg tgacccagca cggtccctct tggaattgga ttcgccattt tatttttctt
1081 gctgctaaat caccgagccc ggaagattag agagttttat ttctgggatt cctgtagaca
1141 cacccaccca catacataca tttatatata tatatattat atatatataa attaa
//