LOCUS HUMPLPA 2777 bp mRNA linear HUM 07-JAN-1995
DEFINITION Human proteolipid protein mRNA (PLP), complete cds.
ACCESSION M27110
VERSION M27110.1
KEYWORDS PLP gene; proteolipid protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2777)
AUTHORS Hudson,L.D., Puckett,C., Berndt,J., Chan,J. and Gencic,S.
TITLE Mutation of the proteolipid protein gene PLP in a human X
chromosome-linked myelin disorder
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86 (20), 8128-8131 (1989)
PUBMED 2479017
COMMENT Original source text: Human (individuals PM1, PM2, PM3 and control
SG) whole blood, fibroblasts, and lymphoblasts, cDNA to mRNA,
clones PLP1.5 and PLP1.3.
Draft entry and computer readable copy of sequence [1] kindly
submitted by L.D.Hudson, 09-AUG-1989.
Base pairs 10-46 of this sequence overlap with base pairs 1272-1307
of the sequence in GenBank entry M27111.
FEATURES Location/Qualifiers
source 1..2777
/db_xref="H-InvDB:HIT000195108"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="Xq21.33-q22"
gene 1..2777
/gene="PLP"
mRNA <1..2777
/gene="PLP"
/note="PLP mRNA (alt.)"
mRNA <1..2773
/gene="PLP"
/note="PLP mRNA (alt.)"
mRNA <1..2757
/gene="PLP"
/note="PLP mRNA (alt.)"
CDS 119..952
/gene="PLP"
/codon_start=1
/product="proteolipid protein"
/protein_id="AAA60117.1"
/db_xref="GDB:G00-120-302"
/translation="MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTE
KLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFG
DYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCTCLGKWLGHPDKFVGITYALT
VVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGK
VCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTK
F"
BASE COUNT 747 a 592 c 631 g 807 t
ORIGIN
1 gaattcggga aaagaccgaa gaaggaggct ggagagacca ggatccttcc agctgaacaa
61 agtcagccac aaagcagact agccagccgg ctacaattgg agtcagagtc ccaaagacat
121 gggcttgtta gagtgctgtg caagatgtct ggtaggggcc ccctttgctt ccctggtggc
181 cactggattg tgtttctttg gggtggcact gttctgtggc tgtggacatg aagccctcac
241 tggcacagaa aagctaattg agacctattt ctccaaaaac taccaagact atgagtatct
301 catcaatgtg atccatgcct tccagtatgt catctatgga actgcctctt tcttcttcct
361 ttatggggcc ctcctgctgg ctgagggctt ctacaccacc ggcgcagtca ggcagatctt
421 tggcgactac aagaccacca tctgcggcaa gggcctgagc gcaacggtaa cagggggcca
481 gaaggggagg ggttccagag gccaacatca agctcattct ttggagcggg tgtgtacttg
541 tttgggaaaa tggctaggac atcccgacaa gtttgtgggc atcacctatg ccctgaccgt
601 tgtgtggctc ctggtgtttg cctgctctgc tgtgcctgtg tacatttact tcaacacctg
661 gaccacctgc cagtctattg ccttccccag caagacctct gccagtatag gcagtctctg
721 tgctgacgcc agaatgtatg gtgttctccc atggaatgct ttccctggca aggtttgtgg
781 ctccaacctt ctgtccatct gcaaaacagc tgagttccaa atgaccttcc acctgtttat
841 tgctgcattt gtgggggctg cagctacact ggtttccctg ctcaccttca tgattgctgc
901 cacttacaac tttgccgtcc ttaaactcat gggccgaggc accaagttct gatcccccgt
961 agaaatcccc ctttctctaa tagcgaggct cctctaacca cacagcctac aatgctgcgt
1021 ctcccatctt aactctttgc ctttgccacc aactggccct cttcttactt gatgagtgta
1081 acaagaaagg agagtcttgc agtgattaag gtctctcttt ggactctccc ctcttatgta
1141 cctcttttag tcattttgct tcatagctgg ttcctgctag aaatgggaaa tgcctaagaa
1201 gatgacttcc caactcgaag tcacaaagga atggaggctc taattgaatt ttcaagcatc
1261 tcctgaggat cagaaagtaa tttcttctca aagggtactt ccactgatgg aaacaaagtg
1321 gaaggaaaga aggtcaggta cagagaagga atgtctttgg tcctcttgcc atctataggg
1381 gccaaatata ttctctttgg tgtacaaaat ggaattcatt ctggtctctc tattaccact
1441 gaagatagaa gaaaaaagaa tgtcagaaaa acaataagag cgtttgccca aatctgccta
1501 ttgcagctgg gagaaggggg tcaaagcaag gatctttcac ccacagaaag agagcactga
1561 ccccgatggc gatggactac tgaagcccta actcagccaa ccttacttac agcataaggg
1621 agcgtagaat ctgtgtagac gaagggggca tctggcctta cacctcgtta gggaagagaa
1681 acagggtgtt gtcagcatct tctcactccc ttctccttga taacagctac catgacaacc
1741 ctgtggtttc caaggagctg agaatagaag gaaactagct tacatgagaa cagactggcc
1801 tgaggagcag cagttcctgg tggctaatgg tgtaacctga gatggccctc tggtagacac
1861 aggatagata actctttgga tagcatgtct ttttttctgt taattagttg tgtactctgg
1921 cctctgtcat atcttcacaa tggtgctcat ttcatggggt attatccatt cagtcatcgt
1981 aggtgatttg aaggtcttga tttgttttag aatgatgcac atttcatgta ttccagtttg
2041 tttattactt atttggggtt gcatcagaaa tgtctggaga ataattcttt gattatgact
2101 gttttttaaa ctaggaaaat tggacattaa gcatcacaaa tgatattaaa aattggctag
2161 ttgaatctat tgggattttc tacaagtatt ctgcctttgc agaaacagat ttggtgaatt
2221 tgaatctcaa tttgagtaat ctgatcgttc tttctagcta atggaaaatg attttactta
2281 gcaatgttat cttggtgtgt taagagttag gtttaacata aaggttattt tctcctgata
2341 tagatcacat aacagaatgc accagtcatc agctattcag ttggtaagct tccaggaaaa
2401 aggacaggca gaaagagttt gagacctgaa tagctcccag atttcagtct tttcctgttt
2461 ttgttaactt tgggttaaaa aaaaaaaaag tctgattggt tttaattgaa ggaaagattt
2521 gtactacagt tcttttgttg taaagagttg tgttgttctt ttcccccaaa gtggtttcag
2581 caatatttaa ggagatgtaa gagctttaca aaaagacact tgatacttgt tttcaaacca
2641 gtatacaaga taagcttcca ggctgcatag aaggaggaga gggaaaatgt tttgtaagaa
2701 accaatcaag ataaaggaca gtgaagtaat ccgtaccttg tgttttgttt tgatttaata
2761 acataacaaa taaccaa
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