LOCUS HUMHSP89KD 7393 bp DNA linear HUM 07-MAR-1995
DEFINITION Homo sapiens heat shock protein (HSP89-alpha) gene, complete cds.
ACCESSION M27024
VERSION M27024.1
KEYWORDS heat shock protein HSP89-alpha.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7393)
AUTHORS Hickey,E., Brandon,S.E., Smale,G., Lloyd,D. and Weber,L.A.
TITLE Sequence and regulation of a gene encoding a human 89-kilodalton
heat shock protein
JOURNAL Mol. Cell. Biol. 9 (6), 2615-2626 (1989)
PUBMED 2527334
COMMENT Original source text: Homo sapiens placenta DNA.
FEATURES Location/Qualifiers
source 1..7393
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/tissue_type="placenta"
regulatory 253..259
/regulatory_class="TATA_box"
/gene="HSP89-alpha"
gene join(282..341,946..1107,1200..1566,1896..2029,2329..2646,
2763..2928,3344..3534,3633..3780,4024..4292,4882..5215,
5505..5614)
/gene="HSP89-alpha"
mRNA join(282..341,946..1107,1200..1566,1896..2029,2329..2646,
2763..2928,3344..3534,3633..3780,4024..4292,4882..5215,
5505..5614)
/gene="HSP89-alpha"
exon 282..341
/gene="HSP89-alpha"
/number=1
intron 342..945
/number=1
CDS join(946..1107,1200..1566,1896..2029,2329..2646,
2763..2928,3344..3534,3633..3780,4024..4292,4882..5215,
5505..5614)
/gene="HSP89-alpha"
/codon_start=1
/product="heat shock protein"
/protein_id="AAA63194.1"
/translation="MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIF
LRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKAD
LINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQY
AWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPI
TLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKK
KKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQ
LEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSE
DLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH
EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFV
ERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKT
KFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNST
MGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQ
THANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD"
exon 946..1107
/gene="HSP89-alpha"
/number=2
intron 1108..1199
/number=2
exon 1200..1566
/gene="HSP89-alpha"
/number=3
intron 1567..1895
/number=3
exon 1896..2029
/gene="HSP89-alpha"
/number=4
intron 2030..2328
/number=4
exon 2329..2646
/gene="HSP89-alpha"
/number=5
intron 2647..2762
/number=5
exon 2763..2928
/gene="HSP89-alpha"
/number=6
intron 2929..3343
/number=6
exon 3344..3534
/gene="HSP89-alpha"
/number=7
intron 3535..3632
/number=7
exon 3633..3780
/gene="HSP89-alpha"
/number=8
intron 3781..4023
/number=8
exon 4024..4292
/gene="HSP89-alpha"
/number=9
intron 4293..4881
/number=9
exon 4882..5215
/gene="HSP89-alpha"
/number=10
intron 5216..5504
/number=10
exon 5505..6277
/gene="HSP89-alpha"
/number=11
regulatory 6255..6260
/regulatory_class="polyA_signal_sequence"
/gene="HSP89-alpha"
polyA_site 6277
/gene="HSP89-alpha"
BASE COUNT 2091 a 1436 c 1902 g 1964 t
ORIGIN
1 gaattccggg ccgcgcaggc gcattgaggc cggcgcgggg gcgtgcgaga ggcgcgcggc
61 ggcgattgag ggaaggttgc ccgggccggg ccacgagcag ggcctgcgcg cgcccgcagg
121 aaggcgcggg ggcggggtgc cgcggcaacg gcgcatgcgt aggcgcgcgg ccgcggcggc
181 ggctggggag ggttcttccg gaagttgggg aggcttctgg aaaaagcgcc gcgcgctggg
241 cgggcccgtg gctatataag gcaggcgcgg gggtggcgcg tcagttgctt cagcgtcccg
301 gtgtggctgt gccgttggtc ctgtgcggtc acttagccaa ggtgacgggt ggttgtgggg
361 gcctgtggag gtggactggg gaccgggact gggggcggct ggcgcggggc ggaggctgtg
421 ggggccggac cagatccctg aagcagccag ggccgcgctc ccgggcggcc gcgctttcta
481 ttccggaggc ctcgggaccg ctgcggtttc cgcaccccgc ttcaggaatg ggccgggcgg
541 ccgcgggctc cccgaggctc tgcagcagcg ccagagctgg cgccgcacgc gaacagagcg
601 gccccgccgg gggtcccccg cccggccccg ctgggggcgc aggcggagga ggccgccgtg
661 gcggagccgc agcccgcgcg ggagggcacc cggggtgttc gttggggacc gcggcggggg
721 actgggcccg ggctgcggcg gcctcccgga agcgcgcaca cgctcgtggt agttgccgcg
781 ctccgaaatg aggtcatcct ttgtcagccg cccttctatt ttcggtttac ttaaacttcg
841 caaatctcca attcggcttt aaaaatattt ggagaacgcg atggaatctc gtgttgcctc
901 tgtagacgtc ctgcaaggtt ttaaaccggc gcggtgtcgt tccagatgcc tgaggaaacc
961 cagacccaag accaaccgat ggaggaggag gaggttgaga cgttcgcctt tcaggcagaa
1021 attgcccagt tgatgtcatt gatcatcaat actttctact cgaacaaaga gatctttctg
1081 agagagctca tttcaaattc atcagatgta agtcacttat taacccagaa tcggattttg
1141 gtttcagtgt gaacttcttg ggggtgctgt atgcttaaat taatattttt tgttaacagg
1201 cattggacaa aatccggtat gaaagcttga cagatcccag taaattagac tctgggaaag
1261 agctgcatat taaccttata ccgaacaaac aagatcgaac tctcactatt gtggatactg
1321 gaattggaat gaccaaggct gacttgatca ataaccttgg tactatcgcc aagtctggga
1381 ccaaagcgtt catggaagct ttgcaggctg gtgcagatat ctctatgatt ggccagttcg
1441 gtgttggttt ttattctgct tatttggttg ctgagaaagt aactgtgatc accaaacata
1501 acgatgatga gcagtacgct tgggagtcct cagcaggggg atcattcaca gtgaggacag
1561 acacaggtag gcacctgaac attcactggt taagtgagcg gtggaagggt ggggtgctgc
1621 aacccttgga tccctgggga tgcggtgaag cttacagaat ttgtgtttgc ccaacgatca
1681 ggaacaagct agagcactta attagtgtaa tggcatgact tggtgggcgg tccttttggg
1741 cgaggcacct tgcccaaaag gttctgctgt ggtggccttt gcatctgtag taacggcaaa
1801 ccttgcttta tagacacgtt ataagggtgt taggcatggc gttgagcact aaattgaatg
1861 tattattaag tcaatctttc tttcttctct tgcaggtgaa cctatgggtc gtggaacaaa
1921 agttatccta cacctgaaag aagaccaaac tgagtacttg gaggaacgaa gaataaagga
1981 gattgtgaag aaacattctc agtttattgg atatcccatt actctttttg taagttttta
2041 tgtaattgca gagtgaattt ctgtctgtag gtgattgggg tgactgtact acatccttag
2101 tccctagatc tgttcaacta gtctgaagcc tggggaacct aagctctact acctaactct
2161 gtaaaagttc ctcgggctat taagtggatg tatcaaatat tgatgaaaag ctgggtgctt
2221 ctcaagttgg ctaatttaga cttgggcctt aggttgaaaa tagtggtgca gcgctgtcgc
2281 ttagttctgg agtgcagcag tgatgtgatt tcgtgttttc ttttgaaggt ggagaaggaa
2341 cgtgataaag aagtaagcga tgatgaggct gaagaaaagg aagacaaaga agaagaaaaa
2401 gaaaaagaag agaaagagtc ggaagacaaa cctgaaattg aagatgttgg ttctgatgag
2461 gaagaagaaa agaaggatgg tgacaagaag aagaagaaga agattaagga aaagtacatc
2521 gatcaagaag agctcaacaa aacaaagccc atctggacca gaaatcccga cgatattact
2581 aatgaggagt acggagaatt ctataagagc ttgaccaatg actgggaaga tcacttggca
2641 gtgaaggtga gtgactgatg ggtgcttcaa gcttgtcctt agattatcat ctttctccac
2701 caccccaaat atcttctata atgcattgtt cattggtact tagtgtatct gttttattac
2761 agcatttttc agttgaagga cagttggaat tcagagccct tctatttgtc ccacgacgtg
2821 ctccttttga tctgtttgaa aacagaaaga aaaagaacaa catcaaattg tatgtacgca
2881 gagttttcat catggataac tgtgaggagc taatccctga atatctgagt aagtatagat
2941 aggaaaaata atcactgtca ctgattaaag aagtactttc tgggtgggca tggtggctca
3001 cacctataat cctagcactt tgggaggccg gggtgggcag atcacttgag gtcaggagtt
3061 caagaccagc ctgggcaaca tggtgaaacc ccatctctac taaattacaa aaattagccc
3121 catgtagtgg caggctgagg catgaaaaca gcttgaaccc ccccgggagg cagaggttgc
3181 agtgagtgga gattgcgcca ctgccctcca gcctgggcaa cagagtgaga ctgtctcaaa
3241 aatacgtccc atcatcttca ggttatcttt gattttggga gtttacatag taccagtttt
3301 gtccttggaa tgactcagtg catttggttt atattttttt cagacttcat tagaggggtg
3361 gtagactcgg aggatctccc tctaaacata tcccgtgaga tgttgcaaca aagcaaaatt
3421 ttgaaagtta tcaggaagaa tttggtcaaa aaatgcttag aactctttac tgaactggcg
3481 gaagataaag agaactacaa gaaattctat gagcagttct ctaaaaacat aaaggttggt
3541 gtaaataacc attagttttc caattggcct ctttagtttt tttttttttt ttttaattca
3601 gaaagtcttt taaagaacat actttgtttc agcttggaat acacgaagac tctcaaaatc
3661 ggaagaagct ttcagagctg ttaaggtact acacatctgc ctctggtgat gagatggttt
3721 ctctcaagga ctactgcacc agaatgaagg agaaccagaa acatatctat tatatcacag
3781 gtaagagaac actatgttac agtcatacac gtcgttctta caaccttgta ggctctgtgg
3841 gtgtgttttc tactcaggta gcactgttac aactggtatt gatctaggca agataattaa
3901 catgaactag gtcattttct gtcttaggtt ctgcctaggt atctggctag caagaaaagt
3961 cagagctaga tgaaaccatt cttaactgtt aaaaggtcta aaagtaactt tgtaatacct
4021 caggtgagac caaggaccag gtagctaact cagcctttgt ggaacgtctt cggaaacatg
4081 gcttagaagt gatctatatg attgagccca ttgatgagta ctgtgtccaa cagctgaagg
4141 aatttgaggg gaagacttta gtgtcagtca ccaaagaagg cctggaactt ccagaggatg
4201 aagaagagaa aaagaagcag gaagagaaaa aaacaaagtt tgagaacctc tgcaaaatca
4261 tgaaagacat attggagaaa aaagttgaaa aggtatgtga atacagcatt tcctgatcat
4321 tgatacttct aaggtgcttt caagcttagt catacatagc ccattttcgc atgttttcaa
4381 cttaaaacag aaaactatgt cgtgtgtggc tgggcgcggt ggctcacgcc tgcaatccca
4441 gcactttggg aggctgaggc agcggatcac aaggtcagga gatcgagacc atcctggcta
4501 acacggtgaa actcagtctc tactaaaaat agaaaaaaat aaaccaggcg tggtggcacg
4561 gcctgtaatc ctagccactt gggaggctga ggcaggagaa tcgcctgaac ccaggaggcg
4621 gaggttgcag tgagccaaga tcgcaccact gcactccagc ctgggtgatg gagcgagact
4681 ctatctcaaa aaaaaaattg tgcatgtaaa acatgaaatt ataacctgtg ctctttggat
4741 acctaatgcg acatttaagt tgtatttgac agtagatagt attttggatc tattgaaatt
4801 tgggttctac agatttcatt tcacaatgaa agtttaggat taatctttct aggttcctag
4861 tcatcacttt ttggattaca ggtggttgtg tcaaaccgat tggtgacatc tccatgctgt
4921 attgtcacaa gcacatatgg ctggacagca aacatggaga gaatcatgaa agctcaagcc
4981 ctaagagaca actcaacaat gggttacatg gcagcaaaga aacacctgga gataaaccct
5041 gaccattcca ttattgagac cttaaggcaa aaggcagagg ctgataagaa cgacaagtct
5101 gtgaaggatc tggtcatctt gctttatgaa actgcgctcc tgtcttctgg cttcagtctg
5161 gaagatcccc agacacatgc taacaggatc tacaggatga tcaaacttgg tctgggtaag
5221 ccttatacta tgtaatgtta aaaagaaaat aaacacacgt gacattgaag aaaatgggta
5281 aactttcagt tatccaaact tggagcacct tgtctgcttg ctgcttggag gtattaaagt
5341 atgttttttt tagggataag taaggtctta caagagcaaa gaaatgaaat tgagactcat
5401 atgtcctgta atactgtctt gaaagcagat agaaaccaag agtattaccc taatagctgg
5461 ctttaagaaa tctttgtaat atgaggattt tattttggaa acaggtattg atgaagatga
5521 ccctactgct gatgatacca gtgctgctgt aactgaagaa atgccacccc ttgaaggaga
5581 tgacgacaca tcacgcatgg aagaagtaga ctaatctctg gctgagggat gacttacctg
5641 ttcagtactc tacaattcct ctgataatat attttcaagg atgtttttct ttatttttgt
5701 taatattaaa aagtctgtat ggcatgacaa ctactttaag gggaagataa gatttctgtc
5761 tactaagtga tgctgtgata ccttaggcac taaagcagag ctagtaatgc tttttgagtt
5821 tcatgttggt ttattttcac agattggggt aacgtgcact gtaagacgta tgtaacatga
5881 tgttaacttt gtggtctaaa gtgtttagct gtcaagccgg atgcctaagt agaccaaatc
5941 ttgttattga agtgttctga gctgtatctt gatgtttaga aaagtattcg ttacatcttg
6001 taggatctac ttttcgaact tttcattccc tgtagttgac aattctgcat gtactagtcc
6061 tctagaaata ggttaaactg aagcaacttg atggaaggat ctctccacag ggcttgtttt
6121 ccaaagaaaa gtattgtttg gaggagcaaa gttaaaagcc tacctaagca tatcgtaaag
6181 ctgttcaaaa ataactcaga cccagtcttg tggatggaaa tgtagtgctc gagtcacatt
6241 ctgcttaaag ttgtaacaaa tacagatgag ttaaaagata ttgtgtgaca gtgtcttatt
6301 tagggggaaa ggggagtatc tggatgacag ttagtccaaa atgtaaaaca ctaggcgctc
6361 agacggagat ggttaaacac tagctgctcc aagggttgac atggtcttcc cagcatgtac
6421 tcagcaggtg tggggtggag cacatgtagg cacagaaaac aggaatgcag acaacatgca
6481 tcccctgcgt ccatgagtta catgtgttct cttagtgtcc acgttgtttt gatgttattc
6541 atggaatacc ttctgtgcta aatacagtca cttaattcct tggccttaca gtgtctcaaa
6601 gttctttaca aatctactta aagccatcct ggctgaggca ggagaatcgc ttgaacctgg
6661 gaggcggagg ttgcggtggg ctgggattgc accattgcac tgcagcctga gcagcaagag
6721 cgaaactcca tctcaaaaaa aagatgaaaa aatcagccca ataggtaaga gtccctctgg
6781 gactgggggt ggtaatggct aaataaaagt cttcacttct gaaatttggt ggttctagag
6841 acaaaacttg gttagatagc atataggatt tgcattctga gcctaacgcc atatataaaa
6901 atgataggaa atgcctggga cttggatatg tgacagtgtc taagggggca gtgcacaggc
6961 agggagagac cttgtctcag tctcgtgcta agcaggtatt gaatgcttgg taaatggcaa
7021 tcacgtttag tcctttaaat tctctgaaaa gttcttaatc cccttcgata atatacagga
7081 ggaattacgt aaattgaggt cttagtagtg gctgaattta aatttaactc caaagcccca
7141 ttttattctg ctaagttttg ttgcgtactg aaaggtgtta gaagaaaggt ttacggtgtt
7201 aaactaggaa gtgaatggca aaaagggtaa aaagtcaatt ttgttttttc ccaggtctag
7261 caagagaata ttaaatctta agatttcttt caattaaaaa cataaggcac ttgagggaat
7321 caagtcaata tagaacctct ataaatgatc tcccaaagta actcatcctc ctggagttac
7381 tgggaaagca ttt
//