LOCUS HUMLCATA 1297 bp mRNA linear HUM 07-JAN-1995
DEFINITION Human lecithin:cholesterol acyltransferase (LCAT) mRNA, 3' end.
ACCESSION M26268
VERSION M26268.1
KEYWORDS lecithin cholesterol acyltransferase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1297)
AUTHORS Tata,F., Chaves,M.E., Markham,A.F., Scrace,G.D., Waterfield,M.D.,
McIntyre,N., Williamson,R. and Humphries,S.E.
TITLE The isolation and characterisation of cDNA and genomic clones for
human lecithin: cholesterol acyltransferase
JOURNAL Biochim. Biophys. Acta 910 (2), 142-148 (1987)
PUBMED 2823898
COMMENT Original source text: Human adult liver, cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1297
/db_xref="H-InvDB:HIT000195043"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="16q22.1"
gene 1..1297
/gene="LCAT"
CDS <1..1277
/gene="LCAT"
/note="lecithin:cholesterol acyltransferase precursor"
/codon_start=2
/protein_id="AAA59499.1"
/db_xref="GDB:G00-119-359"
/translation="LLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQL
EAKLDKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAP
GVQIRVPGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQ
QEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLG
APWGGSIKPMLVLASGDNQGIPHMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFIST
PSFNYTGRDFQRFFADLHFEEGWYMWLQSRDLLAGLPAPGVEVYCLYGVGLPTPRTYI
YDHGFPYTDPVGVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLHGIQHLNMVFSN
LTLEHINAILLGAYRQGPPASPTASPEPPPPE"
sig_peptide <1..25
/gene="LCAT"
/note="lecithin:cholesterol acyltransferase signal
peptide; G00-119-359"
mat_peptide 26..1273
/gene="LCAT"
/product="lecithin:cholesterol acyltransferase;
G00-119-359"
regulatory 1272..1277
/regulatory_class="polyA_signal_sequence"
/gene="LCAT"
/note="G00-119-359"
BASE COUNT 244 a 441 c 345 g 267 t
ORIGIN
1 gctgctgctc cctcctgccg cccccttctg gctcctcaat gtgctcttcc ccccgcacac
61 cacgcccaag gctgagctca gtaaccacac acggcccgtc atcctcgtgc ccggctgcct
121 ggggaatcag ctagaagcca agctggacaa accagatgtg gtgaactgga tgtgctaccg
181 caagacagag gacttcttca ccatctggct ggatctcaac atgttcctac cccttggggt
241 agactgctgg atcgataaca ccagggttgt ctacaaccgg agctctgggc tcgtgtccaa
301 cgcccctggt gtccagatcc gcgtccctgg ctttggcaag acctactctg tggagtacct
361 ggacagcagc aagctggcag ggtacctgca cacactggtg cagaacctgg tcaacaatgg
421 ctacgtgcgg gacgagactg tgcgcgccgc cccctatgac tggcggctgg agcccggcca
481 gcaggaggag tactaccgca agctcgcagg gctggtggag gagatgcacg ctgcctatgg
541 gaagcctgtc ttcctcattg gccacagcct cggctgtcta cacttgctct atttcctgct
601 gcgccagccc caggcctgga aggaccgctt tattgatggc ttcatctctc ttggggctcc
661 ctggggtggc tccatcaagc ccatgctggt cttggcctca ggtgacaacc agggcatccc
721 ccatatgtcc agcatcaagc tgaaagagga gcagcgcata accaccacct ccccctggat
781 gtttccctct cgcatggcgt ggcctgagga ccacgtgttc atttccacac ccagcttcaa
841 ctacacaggc cgtgacttcc aacgcttctt tgcagacctg cactttgagg aaggctggta
901 catgtggctg cagtcacgtg acctcctggc aggactccca gcacctggtg tggaagtata
961 ctgtctttac ggcgtgggcc tgcccacgcc ccgcacctac atctacgacc acggcttccc
1021 ctacacggac cctgtgggtg tgctctatga ggatggtgat gacacggtgg cgacccgcag
1081 caccgagctc tgtggcctgt ggcagggccg ccagccacag cctgtgcacc tgctgcccct
1141 gcacgggata cagcatctca acatggtctt cagcaacctg accctggagc acatcaatgc
1201 catcctgctg ggtgcctacc gccagggtcc ccctgcatcc ccgactgcca gcccagagcc
1261 cccgcctcct gaataaagac cttcctttgc taccgta
//