LOCUS HUMTCBA 2306 bp mRNA linear HUM 03-AUG-1993
DEFINITION Human TCB gene encoding cytosolic thyroid hormone-binding protein,
complete cds.
ACCESSION M26252
VERSION M26252.1
KEYWORDS cytosolic thyroid hormone-binding protein; pyruvate kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2306)
AUTHORS Kato,H., Fukuda,T., Parkison,C., McPhie,P. and Cheng,S.Y.
TITLE Cytosolic thyroid hormone-binding protein is a monomer of pyruvate
kinase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86 (20), 7861-7865 (1989)
PUBMED 2813362
COMMENT Original source text: Human epidermoid carcinoma cell type A431,
cDNA to mRNA, clone TCB.
Draft entry and computer-readable copy of sequence [1] kindly
submitted by Cheng,S.-Y., 19-JUL-1989.
FEATURES Location/Qualifiers
source 1..2306
/db_xref="H-InvDB:HIT000195042"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 90..1685
/note="cytosolic thyroid hormone-binding protein (EC
2.7.1.40)"
/codon_start=1
/protein_id="AAA36672.1"
/translation="MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARN
TGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDP
YLYRPVAVALDTKGPEIRTGLIKGSGTAELELKKGATLKITLDNAYMEKCDENILWLD
YKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDL
PAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEG
VRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESM
IKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHL
QLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPI
IAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDV
VIVLTGWRPGSGFTNTMRVVPVP"
regulatory 2285..2291
/regulatory_class="polyA_signal_sequence"
BASE COUNT 511 a 652 c 656 g 487 t
ORIGIN Chromosome 15q24-26.1.
1 gggcgggagc tgcacgcgcc gtggctccgg atctcttcgt ctttgcagcg tacgcccgag
61 tcggtcagcg ccggaggacc tcagcagcca tgtcgaagcc ccatagtgaa gccgggactg
121 ccttcattca gacccagcag ctgcacgcag ccatggctga cacattcctg gagcacatgt
181 gccgcctgga cattgattca ccacccatca cagcccggaa cactggcatc atctgtacca
241 ttggcccagc ttcccgatca gtggagacgt tgaaggagat gattaagtct ggaatgaatg
301 tggctcgtct gaacttctct catggaactc atgagtacca tgcggagacc atcaagaatg
361 tgcgcacagc cacggaaagc tttgcttctg acccctacct ctaccggccc gttgctgtgg
421 ctctagacac taaaggacct gagatccgaa ctgggctcat caagggcagc ggcactgcag
481 agctggagct gaagaaggga gccactctca aaatcacgct ggataacgcc tacatggaaa
541 agtgtgacga gaacatcctg tggctggact acaagaacat ctgcaaggtg gtggaagtgg
601 gcagcaagat ctacgtggat gatgggctta tttctctcca ggtgaagcag aaaggtgccg
661 acttcctggt gacggaggtg gaaaatggtg gctccttggg cagcaagaag ggtgtgaacc
721 ttcctggggc tgctgtggac ttgcctgctg tgtcggagaa ggacatccag gatctgaagt
781 ttggggtcga gcaggatgtt gatatggtgt ttgcgtcatt catccgcaag gcatctgatg
841 tccatgaagt taggaaggtc ctgggagaga agggaaagaa catcaagatt atcagcaaaa
901 tcgagaatca tgagggggtt cggaggtttg atgaaatcct ggaggccagt gatgggatca
961 tggtggctcg tggtgatcta ggcattgaga ttcctgcaga gaaggtcttc cttgctcaga
1021 agatgatgat tggacggtgc aaccgagctg ggaagcctgt catctgtgct actcagatgc
1081 tggagagcat gatcaagaag ccccgcccca ctcgggctga aggcagtgat gtggccaatg
1141 cagtcctgga tggagccgac tgcatcatgc tgtctggaga aacagccaaa ggggactatc
1201 ctctggaggc tgtgcgcatg cagcacctga ttgcccgtga ggcagaggct gccatctacc
1261 acttgcaatt atttgaggaa ctccgccgcc tggcgcccat taccagcgac cccacagaag
1321 ccaccgccgt gggtgccgtg gaggcctcct tcaagtgctg cagtggggcc ataatcgtcc
1381 tcaccaagtc tggcaggtct gctcaccagg tggccagata ccgcccacgt gcccccatca
1441 ttgctgtgac ccggaatccc cagacagctc gtcaggccca cctgtaccgt ggcatcttcc
1501 ctgtgctgtg caaggaccca gtccaggagg cctgggctga ggacgtggac ctccgggtga
1561 actttgccat gaatgttggc aaggcccgag gcttcttcaa gaagggagat gtggtcattg
1621 tgctgaccgg atggcgccct ggctccggct tcaccaacac catgcgtgtt gttcctgtgc
1681 cgtgatggac cccagagccc ctcctccagc ccctgtccca cccccttccc ccagcccatc
1741 cattaggcca gcaacgcttg tagaactcac tctgggctgt aacgtggcac tggtaggttg
1801 ggacaccagg gaagaagatc aacgcctcac tgaaacatgg ctgtgtttgc agcctgctct
1861 agtgggacag cccagagcct ggctgcccat catgtggccc cacccaatca agggaagaag
1921 gaggaatgct ggactggagg cccctggagc cagatggcaa gagggtgaca gcttcctttc
1981 ctgtgtgtac tctgtccagt tcctttagaa aaaatggatg cccagaggac tcccaaccct
2041 ggcttggggt caagaaacag ccagcaagag ttaggggcct tagggcactg ggctgttgtt
2101 ccattgaagc cgactctggc cctggccctt acttgcttct ctagctctct aggcctctcc
2161 agtttgcacc tgtccccacc ctccactcag ctgtcctgca gcaaacactc caccctccac
2221 cttccatttt cccccactac tgcagcacct ccaggcctgt tgctatagag cctacctgta
2281 tgtcaataaa caacagctga agcacc
//