LOCUS HUMSGII 2336 bp mRNA linear HUM 03-AUG-1993
DEFINITION Human secretogranin II gene, complete cds.
ACCESSION M25756
VERSION M25756.1
KEYWORDS calcium-binding protein; chromogranin; secretogranin;
tyrosine-sulfated secretory granule protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2336)
AUTHORS Gerdes,H.H., Rosa,P., Phillips,E., Baeuerle,P.A., Frank,R.,
Argos,P. and Huttner,W.B.
TITLE The primary structure of human secretogranin II, a widespread
tyrosine-sulfated secretory granule protein that exhibits low pH-
and calcium-induced aggregation
JOURNAL J. Biol. Chem. 264 (20), 12009-12015 (1989)
PUBMED 2745426
COMMENT Original source text: Human pheochromocytoma, cDNA to mRNA, clone
hSgII-2/8.
Draft entry and computer-readable sequence for [1] kindly provided
by W.B.Huttner, 27-JUN-1989.
FEATURES Location/Qualifiers
source 1..2336
/db_xref="H-InvDB:HIT000195010"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 63..1916
/note="secretogranin II"
/codon_start=1
/protein_id="AAA36607.1"
/translation="MAEAKTHWLGAALSLIPLIFLISGAEAASFQRNQLLQKEPDLRL
ENVQKFPSPEMIRALEYIENLRQQAHKEESSPDYNPYQGVSVPLQQKENGDESHLPER
DSLSEEDWMRIILEALRQAENEPQSAPKENKPYALNSEKNFPMDMSDDYETQQWPERK
LKHMQFPPMYEENSRDNPFKRTNEIVEEQYTPQSLATLESVFQELGKLTGPNNQKRER
MDEEQKLYTDDEDDIYKANNIAYEDVVGGEDWNPVEEKIESQTQEEVRDSKENIGKNE
QINDEMKRSGQLGIQEEDLRKESKDQLSDDVSKVIAYLKRLVNAAGSGRLQNGQNGER
ATRLFEKPLDSQSIYQLIEISRNLQIPPEDLIEMLKTGEKPNGSVEPERELDLPVDLD
DISEADLDHPDLFQNRMLSKSGYPKTPGRAGTEALPDGLSVEDILNLLGMESAANQKT
SYFPNPYNQEKVLPRLPYGAGRSRSNQLPKAAWIPHVENRQMAYENLNDKDQELGEYL
ARMLVKYPEIINSNQVKRVPGQGSSEDDLQEEEQIEQAIKEHLNQGSSQETDKLAPVS
KRFPVGPPKNDDTPNRQYWDEDLLMKVLEYLNQEKAEKGREHIAKRAMENM"
sig_peptide 63..152
/note="secretogranin II signal pept (includes pot.
propeptide); putative"
mat_peptide 153..1913
/product="secretogranin II"
BASE COUNT 778 a 458 c 541 g 559 t
ORIGIN
1 cggggaggaa tatgctgtgg agctcctctg ccatataaac aaaaagagga aatctttcaa
61 acatggctga agcaaagacc cactggcttg gagcagccct gtctcttatc cctttaattt
121 tcctcatctc tggggctgaa gcagcttcat ttcagagaaa ccagctgctt cagaaagaac
181 cagacctcag gttggaaaat gtccaaaagt ttcccagtcc tgaaatgatc agggctttgg
241 agtacataga aaacctccga caacaagctc ataaggaaga aagcagccca gattataatc
301 cctaccaagg tgtctctgtc ccccttcagc aaaaagaaaa tggcgatgaa agccacttgc
361 ccgagaggga ttcactgagt gaagaagact ggatgagaat aatactcgaa gctttgagac
421 aggctgaaaa tgagcctcag tctgcaccaa aagaaaataa gccctatgcc ttgaattcag
481 aaaagaactt tccaatggac atgagtgatg attatgagac acagcagtgg ccagaaagaa
541 agcttaagca catgcaattc cctcctatgt atgaagagaa ttccagggat aaccccttta
601 aacgcacaaa tgaaatagtg gaggaacaat atactcctca aagccttgct acattggaat
661 ctgtcttcca agagctgggg aaactgacag gaccaaacaa ccagaaacgt gagaggatgg
721 atgaggagca aaaactttat acggatgatg aagatgatat ctacaaggct aataacattg
781 cctatgaaga tgtggtcggg ggagaagact ggaacccagt agaggagaaa atagagagtc
841 aaacccagga agaggtgaga gacagcaaag agaatatagg aaaaaatgaa caaatcaacg
901 atgagatgaa acgctcaggg cagcttggca tccaggaaga agatcttcgg aaagagagta
961 aagaccaact ctcagatgat gtctccaaag taattgccta tttgaaaagg ttagtaaatg
1021 ctgcaggaag tgggaggtta cagaatgggc aaaatgggga aagggccacc aggctttttg
1081 agaaacctct tgattctcag tctatttatc agctgattga aatctcaagg aatttacaga
1141 tacccccaga agacttaatt gagatgctca aaactgggga gaagccgaat ggatcagtgg
1201 aaccggagcg ggagcttgac cttcctgttg acctagatga catctcagag gctgacttag
1261 accatccaga cctgttccaa aataggatgc tctccaagag tggctaccct aaaacacctg
1321 gtcgtgctgg gactgaggcc ctaccagacg ggctcagtgt tgaggatatt ttaaatcttt
1381 tagggatgga gagtgcagca aatcagaaaa cgtcgtattt tcccaatcca tataaccagg
1441 agaaagttct gccaaggctc ccttatggtg ctggaagatc tagatcgaac cagcttccca
1501 aagctgcctg gattccacat gttgaaaaca gacagatggc atatgaaaac ctgaacgaca
1561 aggatcaaga attaggtgag tacttggcca ggatgctagt taaataccct gagatcatta
1621 attcaaacca agtgaagcga gttcctggtc aaggctcatc tgaagatgac ctgcaggaag
1681 aggaacaaat tgagcaggcc atcaaagagc atttgaatca aggcagctct caggagactg
1741 acaagctggc cccggtgagc aaaaggttcc ctgtggggcc cccgaagaat gatgataccc
1801 caaataggca gtactgggat gaagatctgt taatgaaagt gctggaatac ctcaatcaag
1861 aaaaggcaga aaagggaagg gagcatattg ctaagagagc aatggaaaat atgtaagctg
1921 ctttcattaa ttaccctact ttcattcctc ccaccccaag caaatcccaa catttctctt
1981 cagtgtgttg acttctatcc tgttaacact gtaatatctt taaatgatgt acaggcagat
2041 gaaaccaggt cactggggag tctgcttcat ttcctctgag ctgttatctt gtgtatggat
2101 atgtgtaaat gttatgactc cttgataaaa aatttattat gtccattatt caagaaagat
2161 atctatgact gtgtttaata gtatatctaa tggctgtggc attgttgatg ctcacatatg
2221 ataaaaaagt gtcctataat tctattgaaa gtttttaata tttattgaat tattttgtta
2281 ctgtctgtag cgttttgtgg agtactggac caaaaaaata aagcattata aatata
//