LOCUS HUMADRA2R 3604 bp DNA linear HUM 30-OCT-1994
DEFINITION Human alpha 2 adrenergic receptor gene, complete cds.
ACCESSION M23533
VERSION M23533.1
KEYWORDS adrenergic receptor; alpha-2 andrenergic receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3604)
AUTHORS Fraser,C.M., Arakawa,S., McCombie,W.R. and Venter,J.C.
TITLE Cloning, sequence analysis, and permanent expression of a human
alpha 2-adrenergic receptor in Chinese hamster ovary cells.
Evidence for independent pathways of receptor coupling to adenylate
cyclase attenuation and activation
JOURNAL J. Biol. Chem. 264 (20), 11754-11761 (1989)
PUBMED 2568356
COMMENT Draft entry and computer-readable sequence for [1] kindly submitted
by W.R.McCombie, 30-MAR-1989.
FEATURES Location/Qualifiers
source 1..3604
/db_xref="H-InvDB:HIT000397425"
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="10q23-q25"
misc_binding 1578..1583
/bound_moiety="SP1"
misc_feature 1707..1712
/note="glucocorticoid response element"
misc_feature 1723..1728
/note="GRE related sequence"
gene 2078..3430
/gene="ZNF32"
CDS 2078..3430
/gene="ZNF32"
/note="alpha-2 adrenergic receptor old gene name 'ADRA2R'"
/codon_start=1
/protein_id="AAA51665.1"
/db_xref="GDB:G00-125-339"
/translation="MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLM
LLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFG
KAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVI
SAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVR
IYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGA
PGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLRG
AGRGRRGSGRRLQGRGRSASGLPRRRAGAGGQNREKRFTFVLAVVIGVFVVCWFPFFF
TYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
"
BASE COUNT 555 a 1272 c 1134 g 643 t
ORIGIN
1 ggatcctggc ctctctcgga tctgcaggaa gggtgggctg tgcgggtcca gagtgggatg
61 cccgttctgg ccggcggtgc ctgctgagcc cttcctgatg tgactttatt agacaaaccc
121 ccactcccgc caggggtaga cacacgagta tctgctttag gaagatttct gcaacacggc
181 agggtgcaat tcaaactctg ggttctcctt tcctgagctt agaaaccaat ttgttcggag
241 ataggagaag gctctgttgg cagaagacct aagagacggg aggaggcgcc tggcgtcagc
301 gggtcgcttc tcagccgtga ccacgagcgg ccagcaggtg tcagtgcgtc ctcgctttgc
361 cctggcgctc ggctcctgga cccctcccca cctcggtcta agggggcgcg gtccagaccc
421 cgggtcttgc gtttcccgca gacagcatcg cggctgggag gacacgtagc cgcttcttcc
481 ctaagcggag gtctgaactc cggcttgtac cacttccccg tgggtgctgt ccattccgcc
541 ccaggggttc catccgaagc cgcgccttcc tccctctcca ggaccccttt ctccccagcc
601 tccaggagca ctgcggaccg cgtcggctct ggcccggagc tgggctgctc cagacgtaac
661 tcacaccgga ggttacttcc ctcgatttgg gcggggattc ccttccattt ttttcttccc
721 ttttctccca agatccagct tcttggggca ctcacgggtg cccgttgcgt tctgctccgt
781 cggccccgag ctgcatggcc aactcccagc aggggccgct cctcccctac cccccacccc
841 cgggctccct ctttaagtct ctagctcaag gtacccgcct ctccaaaggg ctcgtcccgc
901 ctgagggcaa cgctccccga ggtccaggct aggcgcgggc gctagactgg cggaggggtg
961 gtgcgagggg cgggggaggg tcggcttccc acgtggggct gacgccggct gctcagcaac
1021 gcttgcttga tcctggggct ataaaacgag tccaccgtga gcgcagcgga gcagcagcag
1081 ctccagctcg gtgcagaagc ccagcagcgc gtgccgccgc ccggccactc cagcgccttc
1141 ttccccgcct tgcgctcctg ccccaactcg cgctgtcgtc ggaccccggc ccatccagca
1201 gcgctcggcg cccaccaggc ggacgcccag gagaacccct gcctccgtcg cggctcctgg
1261 agagctgatc gttcacctgc cccggcccgc ctgaggacgg gggtgccttc atgcggcccc
1321 cacactcctc accccgccgc cgccgccgtc cccgagctcc gcacagtgcg ccccagcccc
1381 agcagggcgc acaactttgg aagtctcgcg gcgctccgag aggcggcaga gtccgcgccc
1441 cagccccggg ccgggccggg ccagaaccgc agcgtctggg ggaagccaga gagtcggtaa
1501 tcgcttcggg gatgtaaggc gacagacata ggacccccga gctcgcatca gcaccttcgg
1561 ctgcctcccg gggtgggggc gggccccgca cacggtaaga cctcttgctt tcgctcaggc
1621 tcaagattca agatacagat attgatatgt atatatatat ttaatttcct gtcatccttc
1681 caagttatca ggccaccgat gatttttgtt ctcccttctt gaagaataaa tctctcttta
1741 cccatcggct ctccctactc tctcccgccg cttagaaata aaacttggct gtattaggag
1801 ctcggagcaa gaaggcgccc accgagagcg tctgaagcgc gagccaggcg cagttcgcgg
1861 gacccggcca tgggccgcta gcggtcctcc agttcgggcc cggcctcctg cggccccctc
1921 cctatgtgag ccgcagccag gcgagcgggg cgccggagga agaggaggac ccacgggcgc
1981 cgggccggaa ggcagctggc agcaggccca ggccagcggg cgcccgcgtt catgttccgc
2041 caggagcagg ccgttggccg agggcagctt tgcgcccatg ggctccctgc agccggacgc
2101 gggcaacgcg agctggaacg ggaccgaggc gccggggggc ggcgcccggg ccacccctta
2161 ctccctgcag gtgacgctga cgctggtgtg cctggccggc ctgctcatgc tgctcaccgt
2221 gttcggcaac gtgctcgtca tcatcgccgt gttcacgagc cgcgcgctca aggcgcccca
2281 aaacctcttc ctggtgtctc tggcctcggc cgacatcctg gtggccacgc tcgtcatccc
2341 tttctcgctg gccaacgagg tcatgggcta ctggtacttc ggcaaggctt ggtgcgagat
2401 ctacctggcg ctcgacgtgc tcttctgcac gtcgtccatc gtgcacctgt gcgccatcag
2461 cctggaccgc tactggtcca tcacacaggc catcgagtac aacctgaagc gcacgccgcg
2521 ccgcatcaag gccatcatca tcaccgtgtg ggtcatctcg gccgtcatct ccttcccgcc
2581 gctcatctcc atcgagaaga agggcggcgg cggcggcccg cagccggccg agccgcgctg
2641 cgagatcaac gaccagaagt ggtacgtcat ctcgtcgtgc atcggctcct tcttcgctcc
2701 ctgcctcatc atgatcctgg tctacgtgcg catctaccag atcgccaagc gtcgcacccg
2761 cgtgccaccc agccgccggg gtccggacgc cgtcgccgcg ccgccggggg gcaccgagcg
2821 caggcccaac ggtctgggcc ccgagcgcag cgcgggcccg gggggcgcag aggccgaacc
2881 gctgcccacc cagctcaacg gcgcccctgg cgagcccgcg ccggccgggc cgcgcgacac
2941 cgacgcgctg gacctggagg agagctcgtc ttccgaccac gccgagcggc ctccagggcc
3001 ccgcagaccc gagcgcggtc cccggggcaa aggcaaggcc cgagcgagcc aggtgaagcc
3061 gggcgacagc ctgcgcggcg cgggccgggg gcgacgggga tcgggacgcc ggctgcaggg
3121 ccgggggagg agcgcgtcgg ggctgccaag gcgtcgcgct ggcgcgggcg ggcagaaccg
3181 cgagaagcgc ttcacgttcg tgctggccgt ggtcatcgga gtgttcgtgg tgtgctggtt
3241 ccccttcttc ttcacctaca cgctcacggc cgtcgggtgc tccgtgccac gcacgctctt
3301 caaattcttc ttctggttcg gctactgcaa cagctcgttg aacccggtca tctacaccat
3361 cttcaaccac gatttccgcc gcgccttcaa gaagatcctc tgtcgggggg acaggaagcg
3421 gatcgtgtga ggtttccgct ggcgcccgcg tagactcacg ctgactgcag gcagcggggg
3481 gcatcgaggg gtgcttagcc ccagggcact cagaaacccg ggcgctgcct gctctgcgtt
3541 tcctcgtctg gggtggctct gcagcctctg cgggcgggcg tctgctgctc ctacaaggga
3601 agct
//