LOCUS HUMIL4A 9900 bp DNA linear HUM 06-JAN-1995
DEFINITION Human interleukin 4 (IL-4) gene, complete cds.
ACCESSION M23442
VERSION M23442.1
KEYWORDS IL-4; interleukin 4.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 9900)
AUTHORS Arai,N., Nomura,D., Villaret,D., Dewaal Malefijt,R., Seiki,M.,
Yoshida,M., Minoshima,S., Fukuyama,R., Maekawa,M., Kudoh,J.,
Shimizu,N., Yokota,K., Abe,E., Yokota,T., Takebe,Y. and Arai,K.
TITLE Complete nucleotide sequence of the chromosomal gene for human IL-4
and its expression
JOURNAL J. Immunol. 142 (1), 274-282 (1989)
PUBMED 2535858
COMMENT Original source text: Homo sapiens placenta DNA.
FEATURES Location/Qualifiers
source 1..9900
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="5q23-q31"
/tissue_type="placenta"
regulatory 1079..1086
/regulatory_class="TATA_box"
/gene="IL4"
/note="G00-120-096"
gene join(1106..1305,1578..1625,6826..7002,9591..9783)
/gene="IL4"
mRNA join(1106..1305,1578..1625,6826..7002,9591..9783)
/gene="IL4"
/product="interleukin 4"
/note="G00-120-096"
prim_transcript 1106..9783
/note="exons and introns; G00-120-096"
exon 1106..1305
/gene="IL4"
/product="interleukin 4"
/note="G00-120-096"
/number=1
CDS join(1171..1305,1578..1625,6826..7002,9591..9692)
/gene="IL4"
/codon_start=1
/product="interleukin 4"
/protein_id="AAA59150.1"
/db_xref="GDB:G00-120-096"
/translation="MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQ
KTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQ
LIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS"
intron 1306..1577
/note="G00-120-096"
/number=1
exon 1578..1625
/gene="IL4"
/product="interleukin 4"
/note="G00-120-096"
/number=2
intron 1626..6825
/note="G00-120-096"
/number=2
exon 6826..7002
/gene="IL4"
/product="interleukin 4"
/note="G00-120-096"
/number=3
intron 7003..9590
/note="G00-120-096"
/number=3
exon 9591..9783
/gene="IL4"
/product="interleukin 4"
/note="G00-120-096"
/number=4
BASE COUNT 2687 a 2204 c 2478 g 2531 t
ORIGIN
1 gaattcaata aaaaacaagc agggcgcgtg gtggggcact gactaggagg gctgatttgt
61 aagttggtaa gactgtagct ctttttccta attagctgag gatgtgttta ggttccattc
121 aaaaagtggg cattcctggc caggcatggt ggctcacacc tgtaatctca gagctttggg
181 agactgaggt aggaggatca cttgagccca ggaatttgag atgagcctag gcaacatagt
241 gagactctta tctctatcaa aaaataaaaa taaaaatgag ccaggcatgg tgcggtggac
301 cacgcaccta ctgctagggg ggctgaggtg ggaggatcat tgagcctggg aggttgaggc
361 tgcagtgatc cctgatcaaa cattgcattt cagcctgggt gacagagtga gaccctgtct
421 cagaaaaaaa aaaaaaaagt cattcctgaa acctcagaat agacctacct tgccaagggc
481 ttccttatgg gtaaggacct tatggacctg ctgggaccca aactaggcct cacctgatac
541 gacctgtcct tctcaaaaca ctaaacttgg gagaacattg tcccccagtg ctggggtagg
601 agagtctgcc tgttattctg cctctatgca gagaaggagc cccagatcat cttttccatg
661 acaggacagt ttccaagatg ccacctgtac ttggaagaag ccaggttaaa atacttttca
721 agtaaaactt tcttgatatt actctatctt tccccaggag gactgcatta caacaaattc
781 ggacacctgt ggcctctccc ttctatgcaa agcaaaaagc cagcagcagc cccaagctga
841 taagattaat ctaaagagca aattatggtg taatttccta tgctgaaact ttgtagttaa
901 ttttttaaaa aggtttcatt ttcctattgg tctgatttca caggaacatt ttacctgttt
961 gtgaggcatt ttttctcctg gaagagaggt gctgattggc cccaagtgac tgacaatctg
1021 gtgtaacgaa aatttccaat gtaaactcat tttccctcgg tttcagcaat tttaaatcta
1081 tatatagaga tatctttgtc agcattgcat cgttagcttc tcctgataaa ctaattgcct
1141 cacattgtca ctgcaaatcg acacctatta atgggtctca cctcccaact gcttccccct
1201 ctgttcttcc tgctagcatg tgccggcaac tttgtccacg gacacaagtg cgatatcacc
1261 ttacaggaga tcatcaaaac tttgaacagc ctcacagagc agaaggtgag tacctatctg
1321 gcaccatctc tccagatgtt ctggtgatgc tctcagtatt tctaggcatg aaaacgttaa
1381 cagctgctag agaagttgga actggtggtt ggtggcagtc cagggcacac agcgaggctt
1441 ctccctgcca ctcttttttc tgagggtttg taggaagttt cctcagttgg agggagtgag
1501 agctgctcat caaggacttc tctgtccggt tggaggttaa ctctgtctct tgctctctca
1561 tttctgcctg gaccaagact ctgtgcaccg agttgaccgt aacagacatc tttgctgcct
1621 ccaaggtaag aagccgtccc acggtctgtt ttagcaaatg gggagatcca tccccaaatg
1681 tctgaacaag aaacttgtct aatggaaaac gagcgggccc aaattaactc taaggtgtta
1741 gatgttttca aagaacgaga agtctgatct ttactcttaa gcatgttttg gtctttctgg
1801 tttcacttga tttagaagac atgtaataga aagcttacat gctgtagtcc tgactcagat
1861 cctggtcaaa gaaaagccct cttgggtttt acttagcttt ggcatagtgc ctggaacgta
1921 ggaggcactc aataaatgcc tgttgaatga gagaattttt ctggcccata catttctgaa
1981 aaaccaaata ctctcacaga aacagatatt gagatgacag gttgagggag ctttcatttt
2041 gtctaagaga cttcctatgg caacagaaaa ggtatcgcca gagcccctcc tcttccacag
2101 cctggccacc taacagccct ctggttccgg ggctgccgtc cagagctctc agcttgctct
2161 ggccggccga actcccctcc agctcggtct ggaaccatcc tgctgggcag cgtccagcac
2221 atccctgctt cgggctgcct gggcacctcg cctctctgcc tcctgtgctg cctcaccccc
2281 acccctctat ctgtagtggg agggagatag atttgacagc tgatagtgca ttttctctga
2341 caaacacatg actacagccg tatcaatagt tttgtgcatt tcagttcctg ttttcatgga
2401 aacacacggc tgagaatgaa agccccaaag cctcaatttc acagtggtct cctaactacc
2461 tgctttccat gcaaactagg gagatgatat ggccaggagt gaagccctgt gtgttgggca
2521 gggtcacact ccagcaccca gaccatagaa cagggcccat cctgcttcat gagggaaact
2581 gctcttcggg cctttagctg gactatctca tttcattagt tatcccggga gtccgataca
2641 ggatgagatt ctgaagggca aatacacact tttttttttt ttttgagata gggtcttgtt
2701 ctgtcaccca ggctggagtg cagtggtgcg atttcagctc atagcagcct ccacctccca
2761 ggctcaagct atcttcctac ctcagcctcc caagtagccg ggacgacagg tgtgcaccac
2821 cacgcctggc taatttttgt atttttttgt agagatggag tcttgccatt ttgcccaggc
2881 ttgtctcgaa cttctgggct caagcaatcc gtccacctcg gcctctcaaa gtgctgggat
2941 tagccactgc acctgggcaa cagtttatgt gtgtgtgtgt gtgtgtgtgt atatatgtgt
3001 gtgtgtgtat atatatgtgt gtatgtatat atgtgtatgt atatgtgtgt gtgtgtgtgt
3061 gtgtgtgtgt gtgtataaaa tctccaagtc catccaaccg agatggctcc tactagaagc
3121 caagagtcca ccgggttgag cactgggtct ctggaggcct gtcggactgc tgagaaggct
3181 ctaacaaagc caagggaagg gccacctcac tagaagccag gcctggagga agggtgaggg
3241 ctgagggctg gaggtaagac tgcctgtggt tttagaccca ggctctgcca ctgactagct
3301 gtgtggctgg ccttcagaca tcttcacagc tctctgcacc tcagtttcca catgtgaaga
3361 tatgaaagtg attctgaagg tgattgcaag gttgattgga atccagctct tgagttagtg
3421 caaagtgtta ttgtgagatg atataaccac gattaaaagc aagaacaggt gcagagaagc
3481 gatgattcta agaaggaggg gaccgggttg gaaaggatca aaccatccag gatgccgagt
3541 ctggggcaat ccatctgggc tgtttctgga agacccccgg gtgcaggcca ggacactgct
3601 gccctcccgt ccttaactcc cctcttcact cagtcctcac tcacctccct ctcacacaca
3661 caaacatctc ctagaataat ccccactgcc tgccttcact cttacccgtc tcatttgcct
3721 cccctgaact tcatcctcct ggagttcacg atctcactct tcactctttt cttcccctcg
3781 aagattcagc actgcttact tacatgttaa gatatttcag aacagtgaaa tgttgctatt
3841 ttcaaaaacc tacaaaggtg gtatgcagag gaaaaggtac ttctttgtgt tcccaaagaa
3901 aacatctttc caaaatccag cctattgatt ttatttcttc gggggaacaa gaattttagt
3961 atctctaagt tgggtagcat tctactcttg gcagttgctg gaaagaaggc actggtctag
4021 gtcctgggct tcacaggtaa cacctgtcag ggtgtctatg aagtcaaggc tgtctgagga
4081 acagcaaagt gggaagaagc aagctggctg gctgatgaag ggtttcttgg gtggacaagt
4141 agttggagcg atttcctatt taccaaagag agctaaagtt cataattcta cagagagttc
4201 cataatgaac ctcaaatacc tctgtttttt gaaggagttt ctcatataca gcactagctg
4261 actatcctgg gcaggatggg agataatgaa tgcagtgcca atcgggctgg atttatatgg
4321 tcctagtgag gctggtcaag aaccgagtta gaactctcac agagtcactg cccacagaag
4381 aaatctccca agtggctgtt tcctgacatt cccgggaggc aggcctcctt ctgagtcact
4441 ccctaagcag ttctgaactg tgaggtcagc caggctgtcc aagtgcactc cctgagccac
4501 tggcagacac actcagcagc cagagctaga caggcaggtg gtaggagtcc agggccacgg
4561 cagggatgga gtgtcgcccc ctcgctgcga taccagagca agtaaaacgt taaggccttg
4621 cactaaagct gcccttagga tgcattcttt taaagttttt ccatttaatg cagactcttt
4681 tcaattctta ttttatcctt gtttccttta gaaagtcctt tgaaaaatat ctttagaggg
4741 ttttttccta tactatgtgg ccatatacgg gtcaaaatta agtttaattt ccaggctcca
4801 agccagcgtt tcagaaaaat ctcaccaagg tttgtggtaa aagaagcaaa gggctgactt
4861 tttggttttc ttgaatctca ctgttccctc tgcagcagca tgcatgtctg cccacctcca
4921 gacacacagg caccatctgc cgccccccat cagcccgtgt cccttccacc tcgactcgcc
4981 tacaaagccc agagaggtct gtttcttggc ccccagagcc caaagatact gacacactct
5041 tacatttcca actagaatca ggaacgagga gtgactctca gtcagttcat taagtaaatg
5101 tctttctaac cgctctgccc atgggacatc acgccccaca ggggaaaggg gaagcttctg
5161 tagcctggga ttctggtgcc tcagtctggg tctagacttt cctgaaaaaa cgttaaaata
5221 tgaactgcat tcctagaatt tagcctacat aaataagaga tgaacacaaa gatttctata
5281 gtttactcac tgccgcttat ttacagaagc aaaaatctgc cacgataggg gcctgacaaa
5341 tgacagtacc actgtgcaat gcgtttctac gcagctctca atcccatgtt ctctaatacc
5401 accgaaggct taggaaatgc ttatggtata tgtaaagagt aaagaagtta caaacagtat
5461 caacagttga cccctatttt aaaaagtatt tttgaaaagt gtgacgatat ttaccaaaat
5521 attaacgagc aatagttacc tctggctggt gggatgagtg aatgtatttt tgttgaatat
5581 atgttacctt tatagtaaat atatgttatc ttgatcatca gaaaaaaaaa tatgtaagaa
5641 cttgaaagct gcttggacag cgctgctgat agaaacccct gagcatcttg tcactgttct
5701 tctgattcag agggtctggg tggggcaggg gtggtctgag attctgtatt tctaagaagc
5761 tcccagtgat gtccatgctg ctgtccatgg accacacttt gagtatcaag ggaccagagc
5821 atgtcggggg agaggctggg gatagctttc tttatctgaa ctggataaag gaactgggct
5881 caagctaaga accctctcca ggttctgcat ctttgttctt cagtgaaaaa tgagaggaca
5941 caccaggcca ggttcagact gagacacaat ccctctcctg ggttcccaat gacttgtctc
6001 ttgtccattc ccttctctaa ggctaagggc cccccaggaa gagccatgtg gccagaccct
6061 cacagttgct ggcattccaa ggagattctc actccgcatc attggtccaa aaggcccctt
6121 acagaagctc tgcccaaggc tcagatcaat ggcacctgct cccagagctc ctctgatctc
6181 ccaggacacc tttccctgat ctgtgcactt atctcttgct gcctggcaaa atgtcttagc
6241 tcctcacttg ggccatgtgc tgctctcctc tcccatgggg agagccacac ggagagtgct
6301 ggccaaagca gcagagttca ggccaaagga tgtgcactca tttattcaac aggcatgcag
6361 gatttccagg gaaagctgga ttttaaaacc tctgggaaca agagcagaac ctgactgaga
6421 gctcatgtgg gcacttttca tagcagaata gctcatgagg tatagagaca cggacgcaga
6481 acgtgggctg tagcgacaga tggtcctgca ttctagtccc cactgtgcct tttcctcatg
6541 ggatgacttt attcaggtac cctttcggca aaatcctcca agagaaagga aactgggagg
6601 ttctggggag aaggctgctg cgtttgcaat tgggagaggt tgttgacaga ggtttatgtc
6661 tgtggcaagc agccttcctt cagtggaata cttgaagaca ggtctgtagt tgagcaaact
6721 cacctccatt tgtcctcctg gaaagaagaa atcaagagga aaaatctctc tcccatcctc
6781 caaatggagc tggcacattg ctatctgtgg catttgtctt tccagaacac aactgagaag
6841 gaaaccttct gcagggctgc gactgtgctc cggcagttct acagccacca tgagaaggac
6901 actcgctgcc tgggtgcgac tgcacagcag ttccacaggc acaagcagct gatccgattc
6961 ctgaaacggc tcgacaggaa cctctggggc ctggcgggct tggtaagctg cactgtattc
7021 ctggcaagcc ggccgcgtgg ctcctggtgg acagcagcct cacttctaaa cactccttag
7081 gagctgcagc acccttggtc aacccattca ttcattcact cattcaataa gtatttgctg
7141 aagttccaca agtgctgggt gtggttctag gtgctgagga cgtgtcacta aagacagcag
7201 gccgagtccc tgttctcatg gaatgttcta atgggagagt tagaaaaaca aacatgtaaa
7261 atgatggcca gcagtgatac gtgctacaaa gaaaaacata gaaataaaga acataagagt
7321 catgggggag ggggctgact taggagctgg tgacattatc tgagcagata tttgaattga
7381 gggagcaggc cacatgacta actagggaga ccattccagg gagaaggagg aggtatgcaa
7441 aggccttagg atggaaatga actaacttcc tgtatttaaa gaccagtagg aaggccagtg
7501 tggctggatc agagtgagtg aggggtagtt tccaggacag cagatcacac aaggccttta
7561 gattccacca cgagtatgga gggaacacct gcagagcttt gggcaggaca aagactgtac
7621 aatctgattt acgtgattta aaagggtcag tctggctact gtgtggtaaa taggctgaaa
7681 gggggaaagc atagaagcaa gatggcctgt tgggaggcta ccacagtaaa ccaggctaga
7741 gatgatggtg gcgtggacag aatgaagcaa gatggcctgt tgggaggcta ccacagtaaa
7801 ccaggctaga gatgatggtg gcgtggacag aatgaagcaa gatggcctgt tgggaggcta
7861 ccacagtaaa ccaggctaga gatgatggtg gcgtggacaa atggagcagt tgaggtgaac
7921 agatttggga tatgactaaa aataaaacca gaagatttgc tgacagatcg gttgtagggg
7981 gtaagataca ggggaggaaa agatgacctc tttgttcctg cccaaacccc tctggcgatg
8041 gtcagtactg tttacagaga gatgaaagac tggcggcaag gcagggctgg aggttcagca
8101 gaagatcaag agttcaattt tgtacatcgt acatgtaagg tggctcttgg atagccaagt
8161 gaaggtgttg agaagatggt tagaaaagtc tggaacttag gggagaggtc agaacttgca
8221 atacaaaaag gagagtcctt agatagatac tgctgaaaat ctgaatgaca gaaagggaga
8281 gatcaaagga ctgagcctga gatcaacaca tggaggtcag gagaggagga tccagccaag
8341 gggcctgagg aggagtgacc agtgaggcag gagaacatgg agagtgggcg gtaccccagg
8401 aagccggtga ggacactcaa ggagggaggg ttgactgtgt caaatgtact gaaaggacag
8461 gtcaggtgag gaccaagaaa ggcccctggg tttggctgat ggaggccatg ggtgaggctg
8521 atgtaaatgg agaggcagga aggaaagccc agctggagtg ggctcaccga ggatagggtg
8581 gcgagaggag acaaagaagg aacagtgagg gcagacaact ctttgaagat gtttagctat
8641 aaggctgcag agaaactgag cccacagctg cagggtggtt atggagtgag ggaagctctt
8701 ttaaggttgg gggtataccc agcatgttaa tgcacctggg ggaatggtcc agtggagcag
8761 gaagaactga agagagcaga aagaggaaga atcattaggg ggcagaagtc cttgtagccc
8821 agagtggatg ttatctaata tcgagtggag gaattaattg gctttagagg agaacaagga
8881 catgtatccc ctctctgggc ctatcacctt gtagacaatg ggataggtca tgggatagga
8941 acttggcaca acacatgttc tctcttttaa ttctctccat tatcttatga agcaggcaag
9001 taggcaaaca attgtcccaa ctttacaaaa gaaactgaag cttttataaa ttaagtagta
9061 catcctaagc aatacaatta ataaatggta gagctgagat tcaaactgaa gcagtggcct
9121 gggggtagca tctggaatcc ttcccacctt tagggctgct gtgctgcggt gctgctgttt
9181 aatggcacag agggccagat gactgaatct ctctcagcag tccaggcagt catgcagaag
9241 gcccagtaga gcaccgggca ggtctgagcc agcatcttca agttccaccc tgtgagcaag
9301 cacttagctg tgacacactt ctcgagagac tggactcccc cccgcgcaac ccacccaaaa
9361 gcagataggt aatggtatac agtaaccatt tctagaagtg taagtagtat gcacccaaaa
9421 taggcaaaac ctgctggcct agtgatagag acaactccca gtcaggctag actggaggcc
9481 ttggttttat aagtgttcag gtgacaagtg ccacagtagg cttgatcaag tagacaggca
9541 ggcaagacaa atgcttacca atgcaagcta atgaaatgtt tcttttgcag aattcctgtc
9601 ctgtgaagga agccaaccag agtacgttgg aaaacttctt ggaaaggcta aagacgatca
9661 tgagagagaa atattcaaag tgttcgagct gaatatttta atttatgagt ttttgatagc
9721 tttatttttt aagtatttat atatttataa ctcatcataa aataaagtat atatagaatc
9781 taacagcaat ggcatttaat gtattggcta tgtttacttg acaaatgaaa ttatggtttg
9841 caacttttag ggaaatcaat ttagtttacc aagagactat aaatgctatg gagccaaaac
//